STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hmgA3-hydroxy-3-methylglutaryl CoA reductase; Converts HMG-CoA to mevalonate. (397 aa)    
Predicted Functional Partners:
MTH_792
3-hydroxy-3-methylglutaryl-CoA-synthase; Function Code:3.04 - Lipid Metabolism, Sterol biosynthesis; similar to, pir:LN:A64493 AC:A64493, p()=8.6E-131, pid=68%; Belongs to the thiolase-like superfamily. UPF0219 family.
 
 0.999
mvk
Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
 
 0.996
sucD
succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
     
 0.898
MTH_1808
Phytoene synthase; Function Code:9.14 - Metabolism of Cofactors and Vitamins, Terpenoid biosynthesis (isomeric hydrocarbon ((C5H8)n); similar to, gp:GI:g1928932 LN:MMU92075, p()=1E-24, pid=29%.
  
 
 0.893
ftsZ
Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
      
 0.884
pyrF
Orotidine 5' monophosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
     
 0.874
MTH_1804
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, sp:LN:YWAB_BACSU AC:P39582, p()=0.000018, pid=14%.
   
 
 0.834
MTH_1805
Unknown; Function Code:14.00 - Unknown; similar to, pir:LN:B48521 AC:B48521:A48521, p()=0.45, pid=16%.
   
 
 0.834
MTH_47
Conserved protein; Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids. Has lower activity with dimethylallyl phosphate (DMAP) and isopentenyl thiolophosphate (ISP). Has low activity with 1-butyl phosphate (BP) and 3-buten-1-yl phosphate (BEP). Has no significant activity with geranyl phosphate (in vitro). Belongs to the isopentenyl phosphate kinase family.
      
 0.827
MTH_564
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:B64509 AC:B64509, p()=8.5E-37, pid=37%; To M.jannaschii MJ1676.
       0.814
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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