STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemLGlutamate-1-semialdehyde aminotransferase. (443 aa)    
Predicted Functional Partners:
hemB
Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 
 0.999
HemA
glutamyl-tRNA reductase.
 
 0.997
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
  
 0.996
hemE
Uroporphyrinogen decarboxylase; Belongs to the uroporphyrinogen decarboxylase family.
 
  
 0.983
hemN-2
Coproporphyrinogen 3 oxidase; Belongs to the anaerobic coproporphyrinogen-III oxidase family.
 
   
 0.965
LB_014
Sensor protein of a two component response regulator.
     
 0.943
ompR
Response regulator.
     
 0.904
HemG
Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
 
  
 0.899
hemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX.
  
  
 0.813
hemN
Coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family.
     
 0.736
Your Current Organism:
Leptospira interrogans
NCBI taxonomy Id: 189518
Other names: L. interrogans serovar Lai str. 56601, Leptospira interrogans serovar Lai str. 56601
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