node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MK1441 | dnaN | MK1441 | MK1030 | Replication factor A (ssDNA-binding protein). | DNA polymerase sliding clamp (PCNA); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.977 |
MK1441 | exo | MK1441 | MK0566 | Replication factor A (ssDNA-binding protein). | 5'-3' exonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Act [...] | 0.803 |
MK1441 | mcm2_1 | MK1441 | MK0965 | Replication factor A (ssDNA-binding protein). | Predicted ATPase involved in replication control, Cdc46/Mcm family; Belongs to the MCM family. | 0.951 |
MK1441 | mcm2_2 | MK1441 | MK1120 | Replication factor A (ssDNA-binding protein). | Predicted ATPase involved in replication control, Cdc46/Mcm family. | 0.951 |
MK1441 | polB | MK1441 | MK1039 | Replication factor A (ssDNA-binding protein). | B family DNA polymerase. | 0.947 |
MK1441 | pri1 | MK1441 | MK0586 | Replication factor A (ssDNA-binding protein). | Eukaryotic-type DNA primase, small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after p [...] | 0.789 |
MK1441 | pri2 | MK1441 | MK1394 | Replication factor A (ssDNA-binding protein). | Eukaryotic-type DNA primase, large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. | 0.811 |
MK1441 | rfcL | MK1441 | MK0005 | Replication factor A (ssDNA-binding protein). | Replication factor C (ATPase involved in DNA replication); Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. | 0.940 |
MK1441 | rfcS | MK1441 | MK0006 | Replication factor A (ssDNA-binding protein). | Replication factor C (ATPase involved in DNA replication) intein containing; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. | 0.930 |
dnaN | MK1441 | MK1030 | MK1441 | DNA polymerase sliding clamp (PCNA); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | Replication factor A (ssDNA-binding protein). | 0.977 |
dnaN | exo | MK1030 | MK0566 | DNA polymerase sliding clamp (PCNA); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 5'-3' exonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Act [...] | 0.999 |
dnaN | mcm2_1 | MK1030 | MK0965 | DNA polymerase sliding clamp (PCNA); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | Predicted ATPase involved in replication control, Cdc46/Mcm family; Belongs to the MCM family. | 0.804 |
dnaN | mcm2_2 | MK1030 | MK1120 | DNA polymerase sliding clamp (PCNA); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | Predicted ATPase involved in replication control, Cdc46/Mcm family. | 0.838 |
dnaN | polB | MK1030 | MK1039 | DNA polymerase sliding clamp (PCNA); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | B family DNA polymerase. | 0.999 |
dnaN | pri1 | MK1030 | MK0586 | DNA polymerase sliding clamp (PCNA); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | Eukaryotic-type DNA primase, small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after p [...] | 0.980 |
dnaN | pri2 | MK1030 | MK1394 | DNA polymerase sliding clamp (PCNA); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | Eukaryotic-type DNA primase, large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. | 0.999 |
dnaN | rfcL | MK1030 | MK0005 | DNA polymerase sliding clamp (PCNA); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | Replication factor C (ATPase involved in DNA replication); Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. | 0.980 |
dnaN | rfcS | MK1030 | MK0006 | DNA polymerase sliding clamp (PCNA); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | Replication factor C (ATPase involved in DNA replication) intein containing; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. | 0.994 |
exo | MK1441 | MK0566 | MK1441 | 5'-3' exonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Act [...] | Replication factor A (ssDNA-binding protein). | 0.803 |
exo | dnaN | MK0566 | MK1030 | 5'-3' exonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Act [...] | DNA polymerase sliding clamp (PCNA); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.999 |