STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hmdN5,N10-methylenetetrahydromethanopterin dehydrogenase (H2-forming); Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT; Belongs to the HMD family. (358 aa)    
Predicted Functional Partners:
mtd
F420 dependent N5,N10-methylenetetrahydromethanopterin dehydrogenase; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT; Belongs to the MTD family.
     
 0.991
mch
Methenyltetrahydromethanopterin cyclohydrolase; Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
     
 0.960
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro- aldol mechanism; Belongs to the SHMT family.
     
  0.900
mer
Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase; Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
     
  0.900
MK1275
Uncharacterized protein conserved in archaea.
     
  0.900
MK0017
Uncharacterized protein conserved in archaea, FLPA ortholog.
  
  
 0.854
MK0016
Predicted enzyme related to biotin synthase.
  
  
 0.809
cooS
Carbon monoxide dehydrogenase catalytic subunit; CODH oxidizes carbon monoxide coupled, via CooF, to the reduction of a hydrogen cation by a hydrogenase (possibly CooH).
      
 0.794
glnA
Glutamine synthase; Belongs to the glutamine synthetase family.
   
  
 0.736
MK0018
Uncharacterized protein conserved in archaea.
     
 0.728
Your Current Organism:
Methanopyrus kandleri
NCBI taxonomy Id: 190192
Other names: M. kandleri AV19, Methanopyrus kandleri AV19, Methanopyrus kandleri str. AV19
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