node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MK0187 | ppcA | MK0187 | MK0190 | Pyruvate-formate lyase-activating enzyme. | Uncharacterized protein conserved in archaea; Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Belongs to the PEPCase type 2 family. | 0.626 |
MK0187 | rnhB | MK0187 | MK0186 | Pyruvate-formate lyase-activating enzyme. | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.705 |
MK0187 | tgt | MK0187 | MK0188 | Pyruvate-formate lyase-activating enzyme. | Queuine/archaeosine tRNA-ribosyltransferase; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family. | 0.781 |
MK0187 | trm1_2 | MK0187 | MK0189 | Pyruvate-formate lyase-activating enzyme. | N2,N2-dimethylguanosine tRNA methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. | 0.773 |
eno | mdh | MK1647 | MK1069 | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | NADPH-dependent L-malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. | 0.836 |
eno | ppcA | MK1647 | MK0190 | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | Uncharacterized protein conserved in archaea; Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Belongs to the PEPCase type 2 family. | 0.900 |
eno | ppsA | MK1647 | MK0252 | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | Phosphoenolpyruvate synthase/pyruvate phosphate dikinase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. | 0.943 |
eno | rnhB | MK1647 | MK0186 | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.533 |
frdB/glpC | mdh | MK0132 | MK1069 | Succinate dehydrogenase/fumarate reductase Fe-S protein. | NADPH-dependent L-malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. | 0.693 |
frdB/glpC | ppcA | MK0132 | MK0190 | Succinate dehydrogenase/fumarate reductase Fe-S protein. | Uncharacterized protein conserved in archaea; Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Belongs to the PEPCase type 2 family. | 0.610 |
frdB/glpC | ppsA | MK0132 | MK0252 | Succinate dehydrogenase/fumarate reductase Fe-S protein. | Phosphoenolpyruvate synthase/pyruvate phosphate dikinase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. | 0.609 |
mdh | eno | MK1069 | MK1647 | NADPH-dependent L-malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | 0.836 |
mdh | frdB/glpC | MK1069 | MK0132 | NADPH-dependent L-malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. | Succinate dehydrogenase/fumarate reductase Fe-S protein. | 0.693 |
mdh | ppcA | MK1069 | MK0190 | NADPH-dependent L-malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. | Uncharacterized protein conserved in archaea; Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Belongs to the PEPCase type 2 family. | 0.924 |
nfnB | ppcA | MK1490 | MK0190 | Nitroreductase. | Uncharacterized protein conserved in archaea; Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Belongs to the PEPCase type 2 family. | 0.576 |
nfnB | purP | MK1490 | MK0588 | Nitroreductase. | Predicted ATP-utilizing enzyme of the ATP-grasp superfamily (probably carboligase); Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. Belongs to the phosphohexose mutase family. | 0.576 |
ppcA | MK0187 | MK0190 | MK0187 | Uncharacterized protein conserved in archaea; Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Belongs to the PEPCase type 2 family. | Pyruvate-formate lyase-activating enzyme. | 0.626 |
ppcA | eno | MK0190 | MK1647 | Uncharacterized protein conserved in archaea; Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Belongs to the PEPCase type 2 family. | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | 0.900 |
ppcA | frdB/glpC | MK0190 | MK0132 | Uncharacterized protein conserved in archaea; Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Belongs to the PEPCase type 2 family. | Succinate dehydrogenase/fumarate reductase Fe-S protein. | 0.610 |
ppcA | mdh | MK0190 | MK1069 | Uncharacterized protein conserved in archaea; Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Belongs to the PEPCase type 2 family. | NADPH-dependent L-malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. | 0.924 |