STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nadKPredicted sugar kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (276 aa)    
Predicted Functional Partners:
nadE
NAD synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
    
 0.969
suhB
Myo-inositol-1(or 4)-monophosphatase; Archaea-specific fructose-1,6-bisphosphatase fused to predicted pyrophosphatase of the PRA-PH family.
 
  
 0.951
sir2
NAD-dependent protein deacetylase, SIR2 family; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. Belongs to the sirtuin family. Class III subfamily.
  
 
 0.943
lpd
Dihydrolipoamide dehydrogenase.
     
 0.923
speA
Pyruvoyl-dependent arginine decarboxylase; PvlArgDC; Belongs to the PdaD family.
       0.837
MK0398
Predicted RNA-binding protein containing the S4 domain.
  
  
 0.749
pncB
Nicotinic acid phosphoribosyltransferase.
     
 0.710
speB
Agmatinase; Belongs to the arginase family.
  
  
 0.699
efp
Translation initiation factor eIF-5A; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family.
     
 0.691
pyrF
Orotidine-5'-phosphate decarboxylase.
 
     0.667
Your Current Organism:
Methanopyrus kandleri
NCBI taxonomy Id: 190192
Other names: M. kandleri AV19, Methanopyrus kandleri AV19, Methanopyrus kandleri str. AV19
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