node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MK0214 | MK0486 | MK0214 | MK0486 | Predicted metal-dependent protease of the PAD1/JAB1 superfamily. | ATPase of the AAA+ class. | 0.915 |
MK0214 | hslV_1 | MK0214 | MK0385 | Predicted metal-dependent protease of the PAD1/JAB1 superfamily. | Protease subunit of the proteasome; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.957 |
MK0214 | hslV_2 | MK0214 | MK1228 | Predicted metal-dependent protease of the PAD1/JAB1 superfamily. | Protease subunit of the proteasome; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.957 |
MK0214 | map | MK0214 | MK0613 | Predicted metal-dependent protease of the PAD1/JAB1 superfamily. | Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val); Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily. | 0.420 |
MK0214 | rpl40A | MK0214 | MK0641 | Predicted metal-dependent protease of the PAD1/JAB1 superfamily. | Ribosomal protein L40E; Belongs to the eukaryotic ribosomal protein eL40 family. | 0.983 |
MK0214 | rpt1 | MK0214 | MK0878 | Predicted metal-dependent protease of the PAD1/JAB1 superfamily. | ATP-dependent 26S proteasome regulatory subunit; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone pro [...] | 0.999 |
MK0486 | MK0214 | MK0486 | MK0214 | ATPase of the AAA+ class. | Predicted metal-dependent protease of the PAD1/JAB1 superfamily. | 0.915 |
MK0486 | hslV_1 | MK0486 | MK0385 | ATPase of the AAA+ class. | Protease subunit of the proteasome; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.926 |
MK0486 | hslV_2 | MK0486 | MK1228 | ATPase of the AAA+ class. | Protease subunit of the proteasome; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.922 |
MK0486 | map | MK0486 | MK0613 | ATPase of the AAA+ class. | Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val); Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily. | 0.898 |
MK0486 | proS | MK0486 | MK1229 | ATPase of the AAA+ class. | Prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). | 0.464 |
MK0486 | rpl40A | MK0486 | MK0641 | ATPase of the AAA+ class. | Ribosomal protein L40E; Belongs to the eukaryotic ribosomal protein eL40 family. | 0.971 |
MK0486 | rpt1 | MK0486 | MK0878 | ATPase of the AAA+ class. | ATP-dependent 26S proteasome regulatory subunit; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone pro [...] | 0.857 |
MK1227 | hslV_2 | MK1227 | MK1228 | Uncharacterized protein; Predicted metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain. | Protease subunit of the proteasome; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.764 |
MK1227 | proS | MK1227 | MK1229 | Uncharacterized protein; Predicted metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain. | Prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). | 0.552 |
hslV_1 | MK0214 | MK0385 | MK0214 | Protease subunit of the proteasome; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | Predicted metal-dependent protease of the PAD1/JAB1 superfamily. | 0.957 |
hslV_1 | MK0486 | MK0385 | MK0486 | Protease subunit of the proteasome; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | ATPase of the AAA+ class. | 0.926 |
hslV_1 | hslV_2 | MK0385 | MK1228 | Protease subunit of the proteasome; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | Protease subunit of the proteasome; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.999 |
hslV_1 | rpl40A | MK0385 | MK0641 | Protease subunit of the proteasome; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | Ribosomal protein L40E; Belongs to the eukaryotic ribosomal protein eL40 family. | 0.935 |
hslV_1 | rpt1 | MK0385 | MK0878 | Protease subunit of the proteasome; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | ATP-dependent 26S proteasome regulatory subunit; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone pro [...] | 0.991 |