STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
tcmID-ring cyclase TcmI; Catalyzing the conversion of tetracenomycin F2 to tetracenomycin F1. (109 aa)    
Predicted Functional Partners:
tcmH
Tetracenomycin polyketide synthesis hydroxylase TcmH; Oxygenase required for conversion of tetracenomycin F1 to tetracenomycin D3.
 
  
 0.981
tcmJ
Tetracenomycin polyketide synthesis protein TcmJ, putative B-ring cyclase; Possibly required for conversion of tetracenomycin F2 to tetracenomycin D3.
 
     0.916
tcmM
Protein of unknown function, TcmM; Acyl carrier protein.
 
     0.856
tcmG
Tetracenomycin polyketide synthesis hydroxylase TcmG; Hydroxylates tetracenomycin A2 at positions C-4, C-4A, and C12A to give tetracenomycin C (TCM C). Hydroxylates as well 9- carboxymethyl-TCM B3 to yield 8-demethyl-TMC C, a side reaction.
 
     0.809
tcmL
Tetracenomycin C polyketide putative beta-ketoacyl synthase 2; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
 
     0.800
AIS01725.1
Hypothetical protein.
 
   
 0.797
curC
Putative polyketide synthase CurC.
 
     0.792
curF
Putative polyketide cyclase.
 
     0.792
AIS01731.1
Hypothetical protein.
 
     0.792
AIS01728.1
Putative cyclase/dehydrase.
 
     0.790
Your Current Organism:
Streptomyces glaucescens
NCBI taxonomy Id: 1907
Other names: ATCC 19761, ATCC 23622, Actinomyces glaucescens, BCRC 11478, CBS 499.68, CCRC 11478, CCRC:11478, CECT 3133, DSM 40155, IFO 12774, IMET 43584, INA 8731, ISP 5155, JCM 4377, LMG 19330, LMG:19330, NBRC 12774, NCIMB 9619, NCIMB 9844, NRRL B-2706, NRRL-ISP 5155, S. glaucescens, UNIQEM 147, VKM Ac-617
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