STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
peb3Original (2000) note: Cj0289c, peb3, major antigenic peptide PEB3, len: 250 aa; 94.9% identical to TR:G234575, sequenced by direct peptide sequencing; see: Pei at al. J. Biol. Chem. 266:16363-16369 (1991). Also similar to TR:Q57410 (EMBL:U39068) Vibrio cholerae accessory colonization factor acfC (253 aa), fasta scores; opt: 855 z-score: 1301.2 E(): 0, 53.6% identity in 239 aa overlap and TR:P96759 (EMBL:U82533) anm (E. coli 045 attachment and effacement negative mutant) (251 aa), fasta scores; opt: 849 z-score: 824.0 E(): 0, 51.8% identity in 251 aa overlap. No Hp match. Also similar t [...] (250 aa)    
Predicted Functional Partners:
motB
Original (2000) note: Cj0336c, motB, possible flagellar motor protein, len: 247 aa; similar to MOTB_BACSU chemotaxis motB protein (motility protein B) (261 aa), fasta scores; opt: 195 z-score: 275.7 E(): 4.2e-08, 30.7% identity in 261 aa overlap. 43.3% identity to HP0816. Contains Pfam match to entry PF00691 OmpA, OmpA family, score 28.50, E-value 5.6e-07; Updated (2006) note: One probable transmembrace helices identified by TMHMM2.0 within CDS. Some characterisation within Bacillus subtilis with marginal identity score. Putative kept within product function. Functional classification [...]
    
   0.769
peb1A
Aspartate/glutamate-binding ABC transporter protein; Common antigen and a major cell adherence molecule. Most probably involved, with PEB1C, in a binding-protein-dependent transport system for an amino acid. May be involved in binding to intestinal cells; Belongs to the bacterial solute-binding protein 3 family.
   
 
 0.711
peb4-cbf2
Original (2000) note: Cj0596, peb4-cbf2, major antigenic peptide PEB4-cell binding factor 2, len: 273 aa; identical to CBF2_CAMJE cell binding factor 2 precursor,and TR:G451285 peb4=major antigenic peptide (34 aa). Also similar to memebers of the PPIC-parvulin family of rotamases e.g. PRTM_LACPA protease maturation protein precursor (299 aa), fasta scores; opt: 238 z-score: 303.5 E(): 1.3e-09, 31.3% identity in 240 aa overlap, and CYPD_ECOLI peptidyl-prolyl cis-trans isomerase D (623 aa),fasta scores; opt: 244 z-score: 293.9 E(): 4.5e-09, 27.1% identity in 221 aa overlap. 35.7% identit [...]
   
 
 0.600
peb2
Original (2000) note: Cj0778, peb2, major antigenic peptide PEB2, len: 245 aa; 94.9% identical to TR:G234576,sequenced by direct peptide sequencing; see: J. Biol. Chem. 266:16363-16369 (1991). Also similar to TR:Q57410 (EMBL:U39068, U15606) Vibrio cholerae accessory colonization factor ACFC (253 aa), fasta scores; opt: 430 z-score: 499.2 E(): 1.7e-20, 33.9% identity in 248 aa overlap, and TR:P96759 (EMBL:U82533)E. coli O45 ANM protein (251 aa), fasta scores; opt: 417 z-score: 484.4 E(): 1.1e-19, 33.2% identity in 247 aa overlap. Contains N-terminal signal sequence; Updated (2006) note: [...]
  
 
0.598
lpxB
lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
  
    0.571
Cj1666c
Putative periplasmic protein; Original (2000) note: Cj1666c, probable periplasmic protein, len: 145 aa; similar to TR:AAD11752 (EMBL:AF067954) Salmonella typhimurium ORF105 in silver resistance cluster (105 aa), fasta scores; opt: 244 z-score: 293.2 E(): 5.2e-09, 39.2% identity in 102 aa overlap, and TR:O67205 (EMBL:AE000724) Aquifex aeolicus AQ_1129 (122 aa), fats scores; opt: 231 z-score: 277.7 E(): 3.8e-08, 33.3% identity in 117 aa overlap. No Hp match. Contains probable N-terminal signal sequence; Updated (2006) note: Pfam domain PF04214 Protein of unknown function, DUF identified [...]
   
    0.532
greA
Transcription elongation factor; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.
  
    0.527
cgpA
Putative periplasmic protein; Original (2000) note: Cj1670c, probable periplasmic protein, len: 220 aa; 27.3% identity to HP0156. Contains probable N-terminal signal sequence; Updated (2006) note: Characterisation paper within Campylobacter jejuni identified new gene name. Papers identified linking protein to glycoprotein (PMID:12186869). Functional classification - Miscellaneous periplasmic proteins; PMID:12186869, PMID:11985725.
      
 0.510
Cj0610c
Putative periplasmic protein; Original (2000) note: Cj0610c, probable periplasmic protein, len: 336 aa; no Hp match. Contains probable N-terminal signal sequence; Updated (2006) note: Pfam domain PF04311 Protein of unknown function (DUF459) was identified within CDS. Product function kept the same. Functional classification - Miscellaneous periplasmic proteins.
      
 0.478
Cj0286c
Hypothetical protein Cj0286c; Original (2000) note: Cj0286c, unknown, len: 205 aa; 28.4% identity to HP0394 (252 aa). Functional classification - Conserved hypothetical proteins.
  
  
 0.466
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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