STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (358 aa)    
Predicted Functional Partners:
serA
Original (2000) note: Cj0891c, serA, probable D-3-phosphoglycerate dehydrogenase, len: 527 aa; similar to e.g. SERA_BACSU D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) (525 aa), fasta scores; opt: 1151 z-score: 1318.2 E(): 0, 36.4% identity in 528 aa overlap. 50.7% identity to HP0397. Also similar to Cj0373 (30.1% identity in 309 aa overlap). Contains PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature, S00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2, and Pfam match to entry PF00389 2-Hacid_DH, D-isomer specific 2-hydroxyacid dehydrogenases [...]
  
 0.982
pheA
Original (2000) note: Cj0316, pheA, probable chorismate mutase/prephenate dehydratase, len: 357 aa; similar to many e.g. PHEA_ECOLI chorismate mutase (EC 5.4.99.5)/prephenate dehydratase (EC 4.2.1.51) (386 aa),fasta scores; opt: 482 z-score: 733.8 E(): 0, 33.1% identity in 366 aa overlap. Similar in N-term to possible truncated pheA in Hp; HP0291 hypothetical protein (96 aa) 35.8% identity in 81 aa overlap. Contains PS00857 and PS00858 Prephenate dehydratase signatures 1 and 2, and Pfam match to entry PF00800 PDT, Prephenate dehydratase,score 268.20, E-value 1.1e-76; Updated (2006) not [...]
  
  
 0.946
Cj0327
Putative endoribonuclease L-PSP family protein; Original (2000) note: Cj0327, unknown, len: 116 aa; similar to hypothetical proteins e.g. YABJ_BACSU (125 aa),fasta scores; opt: 211 z-score: 261.9 E(): 2.5e-07, 33.0% identity in 109 aa overlap, and to e.g. UK14_HUMAN 14.5 kd translational inhibitor protein (137 aa), fasta scores; opt: 173 z-score: 249.5 E(): 1.2e-06, 29.2% identity in 106 aa overlap. No Hp ortholog. Also similar to Cj1388 (33.3% identity in 96 aa overlap). Contains Pfam match to entry PF01042 DUF10, Domain of unknown function, score 69.30, E-value 8.4e-17; Updated (2006 [...]
  
  
 0.874
serB
Putative phosphoserine phosphatase; Original (2000) note: Cj0282c, serB, possible phosphoserine phosphatase, len: 207 aa; similar to C-terminus of SERB_ECOLI phosphoserine phosphatase (EC 3.1.3.3) (322 aa), fasta scores; opt: 361 z-score: 572.4 E(): 1.3e-24, 34.3% identity in 204 aa overlap. 48.8% identity to HP0652; Updated (2006) note: Pfam domain PF00702 haloacid dehalogenase-like hydrolase were identified within CDS. TIGRFAM motif TIGR00338, serB phosphoserine phosphatase identified along with TIGR01488 HAD-SF-IB: HAD-superfamily hydrolase within CDS. Further support for product fu [...]
  
 
 0.862
ubiE
Ubiquinone/menaquinone biosynthesis methlytransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2).
  
 
 0.816
Cj0323
Hypothetical protein Cj0323; Original (2000) note: Cj0323, unknown, len: 398 aa; no Hp match; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Functional classification -Unknown.
       0.807
xseA
Exodeoxyribonuclease VII large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family.
       0.789
pdxA
Putative 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
     
 0.748
aroA
3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
  
  
 0.717
trmE
Putative tRNA modification GTPase; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
 
    
 0.716
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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