STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
trpATryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (249 aa)    
Predicted Functional Partners:
trpD
Anthranilate synthase component II; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
 
 
 0.999
trpF
Original (2000) note: Cj0347, trpF, probable N-(5'-phosphoribosyl)anthranilate isomerase, len: 199 aa; similar to many trpF e.g. TRPF_LACCA N-(5'-phosphoribosyl)anthranilate isomerase (199 aa) (EC 5.3.1.24), fasta scores; opt: 271 z-score: 352.4 E(): 2.3e-12, 31.0% identity in 200 aa overlap, and to the trpF domain of many trpC proteins e.g. TRPC_SALTY indole-3-glycerol phosphate synthase, fasta scores; opt: 307 z-score: 394.5 E(): 1e-14, 30.8% identity in 201 aa overlap. 38.2% identity to C-terminus of HP1279 (trpC) Conatains Pfam match to entry PF00697 PRAI,N-(5'phosphoribosyl)antran [...]
 
 
 0.999
trpB
Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
 0.999
trpC
Original (2000) note: Cj0498, trpC, probable indole-3-glycerol phosphate synthase, len: 258 aa; similar to many e.g. TRPC_PSEAE indole-3-glycerol phosphate synthase (EC 4.1.1.48) (278 aa), fasta scores; opt: 603 z-score: 921.4 E(): 0, 40.8% identity in 260 aa overlap. 37.6% identity to N-terminus of HP1279. Contains PS00614 Indole-3-glycerol phosphate synthase signature and Pfam match to entry PF00218 IGPS, Indole-3-glycerol phosphate synthases, score 360.30, E-value 2.1e-104; Updated (2006) note: Characterised within Pseudomonas aeruginosa with acceptable identity score. Putative not [...]
 
 
 0.997
trpE
Original (2000) note: Cj0345, trpE, possible anthranilate synthase component I, len: 416 aa; similar in C-terminal half to many e.g. TRPE_CLOTM anthranilate synthase component I (EC 4.1.3.27) (494 aa), fasta scores; opt: 784 z-score: 1209.9 E(): 0, 47.0% identity in 281 aa overlap. 35.6% identity in 365 aa overlap to HP1282. Contains Pfam match to entry PF00425 chorismate_bind,chorismate binding enzyme, score 309.50, E-value 3.9e-89; Updated (2006) note: Characterised within Clostridium thermocellum with acceptable identity score,however, sequence alignment was only partial. Thus,putat [...]
 
  
 0.993
pabA
Original (2000) note: Cj0861c, pabA, probable para-aminobenzoate synthase glutamine amidotransferase component II, len: 188 aa; simlar to e.g. PABA_BACSU para-aminobenzoate synthase glutamine amidotransferase component II (EC 4.1.3.-) (194 aa), fasta scores; opt: 534 z-score: 632.3 E(): 6.4e-28, 44.6% identity in 186 aa overlap, and PABA_ECOLI (187 aa), fasta scores; opt: 475 z-score: 564.2 E(): 4e-24, 36.8% identity in 185 aa overlap. 38.6% identity to HP1281 annotated as anthranilate synthase component II (trpD). Contains Pfam match to entry PF00117 GATase, Glutamine amidotransferase [...]
 
 
 0.951
pabB
Original (2000) note: Cj0862c, pabB, probable para-aminobenzoate synthase component I, len: 594 aa; simlar to e.g. PABB_ECOLI para-aminobenzoate synthase component I (EC 4.1.3.-) (453 aa), fasta scores; opt: 541 z-score: 604.3 E(): 2.3e-26, 35.7% identity in 252 aa overlap. 39.3% identity to HP0293. Contains Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme; Updated (2006) note: Characterised in Escherichia coli with acceptable identity score. Putative not added to product function. Functional classification - Biosynthesis of cofactors, prosthetic groups and carrie [...]
 
  
 0.949
lgt
Prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family.
  
    0.851
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
  
  
 0.785
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
   
 
 0.731
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Server load: low (32%) [HD]