STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cmeRTranscriptional regulator CmeR; Original (2000) note: Cj0368c, probable transcriptional regulatory protein, len: 210 aa; similar to members of the tetR family e.g. TR:G3327947 (EMBL:AF053772) Staphylococcus aureus transcriptional regulator qacR (regulator of multidrug efflux protein QacB) (188 aa), fasta scores; opt: 162 z-score: 285.0 E(): 1.3e-08, 29.3% identity in 198 aa overlap, and MTRR_NEIGO regulatory protein MTRR (210 aa), fasta scores; opt: 137 z-score: 210.6 E(): 0.00018, 31.3% identity in 83 aa overlap. No Hp match. Contains Pfam match to entry PF00440 tetR, Bacterial regula [...] (210 aa)    
Predicted Functional Partners:
cmeA
Periplasmic fusion protein CmeA (multidrug efflux system CmeABC); Original (2000) note: Cj0367c, possible membrane fusion component of efflux system, len: 367 aa; similar to e.g. MTRC_NEIGO membrane fusion protein MTRC precursor (412 aa), fasta scores; opt: 592 z-score: 692.4 E(): 2.6e-31, 29.9% identity in 358 aa overlap, and TR:P95421 (EMBL:X99514) Pseudomonas aeruginosa mexE (antibiotic efflux system protein) (414 aa), fasta scores; opt: 460 z-score: 570.0 E(): 1.7e-24, 26.9% identity in 357 aa overlap. No Hp ortholog. Contains N-terminal signal sequence and PS00013 Prokaryotic memb [...]
  
  
 0.854
cmeC
Outer membrane channel protein CmeC (multidrug efflux system CmeABC); Original (2000) note: Cj0365c, possible outer membrane channel protein, len: 492 aa; similar to members of the nodT/fusA family e.g. TR:O31101 (EMBL:AF029405) Pseudomonas putida outer membrane channel protein SRPC (470 aa), fasta scores; opt: 645 z-score: 834.4 E(): 0,29.2% identity in 465 aa overlap. and TR:Q51006 (EMBL:X95635) Neisseria gonorrhoeae mtrE gene (467 aa,fasta scores; opt: 663 z-score: 829.8 E(): 0, 31.1% identity in 476 aa overlap. No Hp match. Also some similarity to Cj0608 (28.6% identity in 455 aa o [...]
  
  
 0.853
cmeB
Inner membrane efflux transporter CmeB (multidrug efflux system CmeABC); Original (2000) note: Cj0366c, probable transmembrane efflux protein, len: 1040 aa; similar to e.g. TR:P95422 (EMBL:X99514) Pseudomonas aeruginosa mexF (antibiotic efflux system protein) (1062 aa), fasta scores; opt: 1584 z-score: 3208.4 E(): 0, 41.2% identity in 1056 aa overlap, and ACRB_ECOLI acriflavin resistance protein B (1049 aa), fasta scores; opt: 2739 z-score: 3055.6 E(): 0, 41.7% identity in 1031 aa overlap. No Hp ortholog. Contains Pfam match to entry PF00873 ACR_tran,AcrB/AcrD/AcrF family, score 1415.1 [...]
  
  
 0.852
Cj0369c
Original (2000) note: Cj0369c, ferredoxin domain-containing integral membrane protein, len: 458 aa; some similarity to e.g. RDXA_RHOSH RDXA protein (469 aa),fasta scores; opt: 474 z-score: 657.7 E(): 2.2e-29, 24.9% identity in 402 aa overlap, and FIXG_RHIME nitrogen fixation protein FIXG (524 aa), fasta scores; opt: 476 z-score: 533.8 E(): 1.8e-22, 28.7% identity in 296 aa overlap. 45.7% identity to HP1508. Contains PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature and Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains., [...]
  
  
 0.832
gyrA
DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
   
  
 0.740
ftsZ
Cell division protein FfsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
    
 
 0.685
Cj0415
Original (2000) note: Cj0415, possible oxidoreductase subunit, len: 573 aa; similar to e.g. TR:O34214 (EMBL:U97665) Erwinia cypripedii gluconate dehydrogenase subunit precursor (615 aa), fasta scores; opt: 1025 z-score: 1674.4 E(): 0, 40.8% identity in 583 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF00732 GMC (glucose-methanol-choline) oxidoreductase was identified within CDS when carrying out own Pfam search. This family is a member of the FAD/NAD(P)-binding Rossmann fold Superfamily clan. These proteins bind FAD as a cofactor. Product modified to more specific family [...]
   
 
 0.640
pth
peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family.
   
    0.632
rpsU
Original (2000) note: Cj0370, rpsU, 30S ribosomal protein S21, len: 70 aa; similar to many e.g. RS21_ECOLI 30S ribosomal protein S21 (70 aa), fasta scores; opt: 169 z-score: 341.8 E(): 8.8e-12, 45.7% identity in 70 aa overlap. 80.0% identity to HP0562. Contains Pfam match to entry PF01165 S21, Ribosomal protein S21, score 91.50,E-value 1.6e-23; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. Putative not added to product function. Functional classification -Ribosomal protein synthesis and modification; PMID:16272117.
  
  
 0.613
cmeD
Original (2000) note: Cj1031, possible outer membrane component of efflux system, len: 424 aa; similar to members of the PRTF family of secretion proteins e.g. TR:O68960 (EMBL:AF059041) putative outer membrane pore protein hefA (=HP0605) (477 aa), fasta scores; opt: 238 z-score: 261.5 E(): 2.9e-07, 25.2% identity in 409 aa overlap, and TOLC_SALEN outer membrane protein TOLC precursor (491 aa), fasta scores; opt: 174 z-score: 192.9 E(): 0.0019, 21.5% identity in 437 aa overlap. 24.8% identity to HP0605. Contains probable N-terminal signal sequence; Updated (2006) note: Pfam domains x2 P [...]
 
   
 0.596
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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