STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
crcBCrcB protein homolog; Important for reducing fluoride concentration in the cell, thus reducing its toxicity; Belongs to the CrcB (TC 9.B.71) family. (122 aa)    
Predicted Functional Partners:
plsC
Original (2000) note: Cj0516, plsC, possible 1-acyl-SN-glycerol-3-phosphate acyltransferase, len: 230 aa; similar to e.g. PLCB_HUMAN 1-acyl-SN-glycerol-3-phosphate acyltransferase (EC 2.3.1.51) (278 aa), fasta scores; opt: 227 z-score: 328.0 E(): 5.7e-11, 25.7% identity in 210 aa overlap. 38.4% identity to HP1348; Updated (2006) note: Pfam domain PF01553 Acyltransferase along with Prosite domains PS50239 GLYCEROL_ACYLTRANS, Phospholipid/glycerol acyltransferase and PS00989 CLAT_ADAPTOR_S, Clathrin adaptor complex,small chain were all identified within CDS. Further support given to prod [...]
  
    0.815
purS
Phosphoribosylformylglycinamidine (FGAM) synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to ass [...]
       0.799
purQ
Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...]
       0.799
Cj0515
Putative periplasmic protein; Original (2000) note: Cj0515, possible periplasmic protein, len: 398 aa; 27.2% identity to HP1349; Updated (2006) note: One probable transmembrane helices predicted by TMHMM2.0 within CDS. Functional classification - Miscellaneous periplasmic proteins.
       0.799
purC
Original (2000) note: Cj0512, purC, probable phosphoribosylaminoimidazole-succinocarboxamide synthase,len: 236 aa; highly similar to many e.g. PUR7_BACSU phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6) (241 aa), fasta scores; opt: 821 z-score: 1330.0 E(): 0, 53.0% identity in 234 aa overlap. No Hp match. Contains PS01057 SAICAR synthetase signature 1 and Pfam match to entry PF01259 SAICAR_synt, SAICAR synthetase, score 311.00, E-value 1.5e-89; Updated (2006) note: Characterised within Bacillus subtilis with acceptable identity score. Putative not added to product [...]
  
    0.797
Cj0511
Putative secreted protease; Original (2000) note: Cj0511, probable secreted protease, len: 444 aa; similar to many e.g. PRC_ECOLI tail-specific protease precursor (682 aa), fasta scores; opt: 357 z-score: 500.2 E(): 1.4e-20, 29.9% identity in 388 aa overlap. 54.3% identity to HP1350. Contains possible N-terminal signal sequence and Pfam match to entry PF00595 PDZ, PDZ domain (Also known as DHR or GLGF)., score 52.00, E-value 1.3e-11; Updated (2006) note: Pfam domain PF03572 Peptidase family S41 identified within CDS. Further support given to product function. Characterised within Esche [...]
       0.794
htpG
Hsp90 family heat shock protein; Molecular chaperone. Has ATPase activity.
       0.619
Cj0519
Putative rhodanese-like domain protein; Original (2000) note: Cj0519, unknown, len: 105 aa; similar to hypothetical proteins e.g. TR:E1342888 (EMBL:AJ235272) Rickettsia prowazekii RP600 (123 aa),fasta scores; opt: 151 z-score: 214.9 E(): 0.00011, 41.6% identity in 89 aa overlap. 34.3% identity to HP1223; Updated (2006) note: Prosite domain PS50206 RHODANESE_3, Rhodanese domain profile also identified within CDS. Rhodanese, a sulphurtransferase involved in cyanide detoxification shares evolutionary relationship with a large family of proteins. This domain is found as a single copy in ot [...]
       0.619
Cj0510c
Original (2000) note: Cj0510c, unknown, len: 96 aa; similar to hypothetical proteins e.g. TR:O32222 (EMBL:Z99121) B. subtilis YVGZ protein (101 aa), fasta scores; opt: 212 z-score: 338.9 E(): 1.4e-11, 40.0% identity in 95 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF02583 Uncharacterised BCR, COG1937 identified within CDS. Conserved added to product function. Functional classification - Conserved hypothetical proteins.
     
 0.581
Cj0520
Putative membrane protein; Original (2000) note: Cj0520, possible membrane protein, len: 144 aa; no Hp match. Contains one possible transmembrane domain at N-terminus. Functional classification - Membranes, lipoproteins and porins.
       0.568
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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