STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
icdIsocitrate dehydrogenase; Original (2000) note: Cj0531, icd, probable isocitrate dehydrogenase, len: 734 aa; highly similar to e.g. IDH2_VIBA1 isocitrate dehydrogenase (NADP) 2 (EC 1.1.1.42) (741 aa), fasta scores; opt: 2534 z-score: 3250.7 E(): 0, 53.3% identity in 733 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF03971 Monomeric isocitrate dehydrogenase identified within CDS. Further support given to product function. Characterised within Vibrio sp. strain ABE-1 with acceptable identity score. Putative not added to product function. Functional classification - Energy me [...] (734 aa)    
Predicted Functional Partners:
oorD
Original (2000) note: Cj0535, oorD, probable OORD subunit of 2-oxoglutarate:acceptor oxidoreductase, len: 103 aa; similar to TR:O68227 (EMBL:AF021094) H. pylori OORD subunit of 2-oxoglutarate:acceptor oxidoreductase (113 aa), fasta scores; opt: 436 z-score: 768.9 E(): 0,59.8% identity in 97 aa overlap. 59.8% identity to HP0588. Contains 2x PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature and Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains., score 17.40, E-value 0.00091; Updated (2006) note: Characterised within Helico [...]
  
 
 0.991
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily.
  
  
 0.984
oorC
Original (2000) note: Cj0538, oorC, probable OORC subunit of 2-oxoglutarate:acceptor oxidoreductase, len: 185 aa; similar to TR:O68230 (EMBL:AF021094) H. pylori OORC subunit of 2-oxoglutarate:acceptor oxidoreductase (184 aa), fasta scores; opt: 714 z-score: 1191.4 E(): 0,59.7% identity in 181 aa overlap. 60.8% identity to HP0591; Updated (2006) note: Pfam domain PF01558 Pyruvate ferredoxin/flavodoxin oxidoreductase identified within CDS. Further support given to product function. Characterised within Helicobacter pylori with acceptable identity score. Putative not added to product func [...]
  
 
 0.983
oorA
Original (2000) note: Cj0536, oorA, probable OORA subunit of 2-oxoglutarate:acceptor oxidoreductase, len: 374 aa; similar to TR:O68228 (EMBL:AF021094) H. pylori OORA subunit of 2-oxoglutarate:acceptor oxidoreductase (371 aa), fasta scores; opt: 1447 z-score: 2256.7 E(): 0,62.7% identity in 351 aa overlap. 63.2% identity to HP0589; Updated (2006) note: Pfam domain PF01855 Pyruvate flavodoxin/ferredoxin oxidoreductase identified within CDS. Further support given to product function. Characterised within Helicobacter pylori with acceptable identity score. Putative not added to product fun [...]
  
 
 0.982
Cj1476c
Original (2000) note: Cj1476c, probable pyruvate-flavodoxin oxidoreductase, len: 1186 aa; highly similar to many e.g. NIFJ_ECOLI probable pyruvate-flavodoxin oxidoreductase (1174 aa), fasta scores; opt: 3586 z-score: 3799.5 E(): 0, 47.2% identity in 1193 aa overlap. N-term has 28.6% identity to HP1110,C-term has 29.7% identity to HP1111. Contains 2x PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature,and Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains; Updated (2006) note: Pfam domains PF02775 Thiamine pyrophosphate enzy [...]
  
 
 0.977
oorB
Original (2000) note: Cj0537, oorB, probable OORB subunit of 2-oxoglutarate:acceptor oxidoreductase, len: 281 aa; similar to TR:O68229 (EMBL:AF021094) H. pylori OORB subunit of 2-oxoglutarate:acceptor oxidoreductase (274 aa), fasta scores; opt: 1356 z-score: 2118.6 E(): 0,69.7% identity in 274 aa overlap. 72.9% identity to HP0590; Updated (2006) note: Pfam domain PF02775 Thiamine pyrophosphate enzyme, C-terminal identified within CDS. Further support given to product function. Characterised within Helicobacter pylori with acceptable identity score. Putative not added to product functio [...]
  
 
  0.961
sucC
succinyl-coA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
  
 0.936
sucD
succinyl-coA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
  
 0.909
acnB
Aconitate hydratase; Original (2000) note: Cj0835c, acnB, probable aconitate hydratase, len: 848 aa; highly similar to e.g. ACO2_ECOLI aconitate hydratase 2 (EC 4.2.1.3) (865 aa),fasta scores; opt: 2785 z-score: 3084.1 E(): 0, 60.5% identity in 858 aa overlap. 65.8% identity to HP0779. Contains PS00450 and PS01244 Aconitase family signatures 1 and 2, and Pfam match to entry PF00330 aconitase; Updated (2006) note: Pfam domain PF06434 Aconitate hydratase identified within CDS. Further support given to product function. Characterised within Escherichia coli with acceptable identity score. [...]
   
 
 0.877
gltB
Original (2000) note: Cj0007, gltB, probable glutamate synthase (NADPH) large subunit, len: 1496 aa; similar to many e.g. GLTB_ECOLI glutamate synthase (NADPH) large chain (1517 aa), fasta scores; opt: 3846 z-score: 3828.3 E(): 0, 42.5% identity in 1488 aa overlap. No Hp match; Updated (2006) note: Pfam domains PF00310 Glutamine amidotransferases class-II, PF04898 Glutamate synthase central domain, PF01645 Conserved region in glutamate synthase and PF01493 GXGXG motif were all identified within CDS. Further support given to product function. Characterised within Bacillus subtilis with [...]
   
 
 0.873
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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