STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
speABiosynthetic arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily. (611 aa)    
Predicted Functional Partners:
cysE
Serine acetyltransferase; Original (2000) note: Cj0763c, cysE, probable serine acetyltransferase, len: 212 aa; highly similar to many e.g. CYSE_BACSU serine acetyltransferase (EC 2.3.1.30) (217 aa), fasta scores; opt: 598 z-score: 700.2 E(): 1e-31, 46.6% identity in 204 aa overlap. 50.9% identity to HP1210. Contains PS00101 Hexapeptide-repeat containing-transferases signature and 2x Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats); Updated (2006) note: Characterised in Bacillus subtilis with acceptable identity score. Putative not added to product f [...]
  
    0.806
coaD
Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family.
  
    0.800
hisS
histidyl-tRNA synthetase; Original (2000) note: Cj0765c, hisS, probable histidyl-tRNA synthetase, len: 408 aa; similar to many e.g. SYH_ECOLI histidyl-tRNA synthetase (EC 6.1.1.21) (423 aa), fasta scores; opt: 927 z-score: 1052.2 E(): 0, 37.6% identity in 407 aa overlap. 29.8% identity to HP1190. Contains PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2 and Pfam match to entry PF00587 tRNA-synt_2b, tRNA synthetases class II (Gly, His, Pro and Ser); Updated (2006) note: Characterised in Escherichia coli with acceptable identity score. Putative not added to product functio [...]
       0.799
tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
       0.799
Cj0949c
Putative peptidyl-arginine deiminase family protein; Original (2000) note: Cj0949c, unknown, len: 325 aa; similar to hypothetical proteins e.g. TR:O86509 (EMBL:AL031124) Streptomyces coelicolor SC1C2.08 (339 aa),fasta scores; opt: 283 z-score: 328.5 E(): 5.3e-11, 24.3% identity in 333 aa overlap. 45.5% identity to HP0049; Updated (2006) note: Pfam domain PF04371 Porphyromonas-type peptidyl-arginine deiminase identified within CDS. Product modified to more specific family member based on motif match. Not fully characterised yet,so putative kept within product function. Functional classi [...]
 
  
 0.767
aspB
Aspartate aminotransferase; Original (2000) note: Cj0762c, aspB, probable aspartate aminotransferase, len: 389 aa; similar to e.g. AAT1_BACSU aspartate aminotransferase (EC 2.6.1.1) (393 aa), fasta scores; opt: 1216 z-score: 1352.8 E(): 0, 50.6% identity in 393 aa overlap. 57.5% identity to HP0672. Contains Pfam match to entry PF00155 aminotran_1,Aminotransferases class-I; Updated (2006) note: Characterised in Bacillus subtilis with acceptable identity score. Putative not added to product function. Functional classification -Amino acid biosynthesis - Aspartate family; PMID:10712618.
  
 
  0.734
argH
Argininosuccinate lyase; Original (2000) note: Cj0931c, argH,argininosuccinate lyase, len: 460 aa; 97.4% identical to ARLY_CAMJE argininosuccinate lyase (EC 4.3.2.1) (459 aa),and highly similar to many e.g. ARLY_CANAL argininosuccinate lyase (EC 4.3.2.1) (468 aa), fasta scores; opt: 1337 z-score: 1518.4 E(): 0, 44.7% identity in 459 aa overlap. No Hp ortholog. Contains PS00163 Fumarate lyases signature, and Pfam match to entry PF00206 lyase_1, Lyases; Updated (2006) note: Characterised in Campylobacter jejuni, so putative not added to product function. Functional classification - Amino [...]
   
 
 0.700
ubiX
Putative decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family.
  
    0.697
flgA
Putative flagellar protein FlgA; Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P- ring assembly; Belongs to the FlgA family.
       0.689
argD
Putative acetylornithine/succinyldiaminopimelate aminotransferase; Original (2000) note: Cj0227, argD, probable acetylornithine aminotransferase, len: 395 aa; simlar to many e.g. ARGD_ECOLI acetylornithine aminotransferase (EC 2.6.1.11) (406 aa), fasta scores; opt: 921 z-score: 1042.0 E(): 0, 36.6% identity in 385 aa overlap. No Hp ortholog. Contains Pfam match to entry PF00202 aminotran_3,Aminotransferases class-III pyridoxal-phosphate, score 378.20, E-value 5.1e-131; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. Based on current literature [...]
      
 0.533
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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