STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ddlAD-alanine--D-alanine ligase; Cell wall formation. (346 aa)    
Predicted Functional Partners:
murC
UDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family.
 
 0.997
murF
UDP-N-acetylmuramoyl-tripeptide D-alanyl-D-alanine ligase; Original (2000) note: Cj0795c, murF, possible UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate -- ligase, len: 475 aa; some similarity to e.g. MURF_BACSU UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate -- ligase (EC 6.3.2.15) (457 aa), fasta scores; opt: 235 z-score: 258.7 E(): 4.1e-07, 26.7% identity in 348 aa overlap. 41.5% identity to HP0740; Updated (2006) note: Pfam domains PF01225 Mur ligase family, catalytic domain and PF02875 Mur ligase family, glutamate ligase domain were identified within CDS. Also, [...]
 
 
 0.992
murD
UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family.
 
 
 0.982
murG
Putative undecaprenyldiphospho-muramoylpentapeptide b-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily.
 
  
 0.960
alr
Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family.
 
  
 0.952
murE
UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily.
 
 
 0.951
mraY
phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily.
 
 
 0.922
Cj1038
Original (2000) note: Cj1038, probable cell division/peptidoglycan biosynthesis protein, len: 387 aa; similar to members of the FTSW/RODA/SPOVE family e.g. RODA_ECOLi rod shape-determining protein RODA (370 aa),fasta scores; opt: 297 z-score: 358.2 E(): 1.2e-12, 27.1% identity in 388 aa overlap, and FTSW_ECOLI cell division protein FTSW (414 aa), fasta scores; opt: 288 z-score: 346.8 E(): 5.1e-12, 28.4% identity in 394 aa overlap. 46.4% identity to HP1560. Contains Pfam match to entry PF01098 FTSW_RODA_SPOVE, Cell cycle protein; Updated (2006) note: Ten probable transmembrane helices p [...]
 
  
 0.921
ftsA
Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family.
  
  
 0.894
Cj0796c
Putative hydrolase; Original (2000) note: Cj0796c, unknown, len: 239 aa; 46.3% identity to HP0739 (annotated as 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase); Updated (2006) note: Pfam domain PF00561 alpha/beta hydrolase fold and Prosite domain PS50187 Esterase/lipase/thioesterase active site serine identified within CDS. The latter are found in alpha/beta fold hydrolase. Product function modified due to motif match. No specific characterisation with acceptable identity score carried out yet. Putative kept within product function. Functional classification - Misc.
 
   
 0.867
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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