STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
nadENH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (246 aa)    
Predicted Functional Partners:
nadD
Putative nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
 
 
 0.890
lpxK
Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
  
    0.815
thrC
Threonine synthase. Functional classification-Amino acid biosynthesis-Aspartate family; Updated (2006) note: Characterised within Pseudomonas aeruginosa with acceptable identity score. Appropriate motifs present. Putative not added to product function; Original (2000) note: Cj0812, thrC, probable threonine synthase, len: 470 aa; similar to e.g. THRC_YEAST threonine synthase (EC 4.2.99.2) (514 aa),fasta scores; opt: 595 z-score: 671.2 E(): 4.3e-30, 33.6% identity in 464 aa overlap, and THRC_PSEAE (470 aa), fasta scores; opt: 647 z-score: 730.2 E(): 0, 32.3% identity in 434 aa overlap. 4 [...]
  
    0.803
kdsB
Original (2000) note: Cj0813, kdsB, probable 3-deoxy-manno-octulosonate cytidylyltransferase, len: 239 aa; similar to e.g. KDSB_ECOLI 3-deoxy-manno-octulosonate cytidylyltransferase (EC 2.7.7.38) (247 aa), fasta scores; opt: 519 z-score: 611.2 E(): 9.6e-27, 39.7% identity in 242 aa overlap. 47.9% identity to HP0230; Updated (2006) note: Pfam domain PF02348 Cytidylyltransferase identified within CDS. Further support given to product function. Characterised in Escherichia coli with acceptable identity score, so putative not added to product function. Functional classification - Surface p [...]
  
    0.799
fliY
Original (2000) note: Cj0059c, fliY, probable flagellar motor switch protein, len: 280 aa; similar to e.g. TR:P74928 (EMBL:U36839) Treponema pallidum flagellar motor switch protein fliY (348 aa), fasta scores; opt: 277 z-score: 496.5 E(): 2.1e-20, 26.2% identity in 309 aa overlap. Also similar in C-terminus to FLIN_BORBU flagellar motor switch protein fliN (113 aa), fasta scores; opt: 231 z-score: 362.5 E(): 6.2e-13, 44.2% identity in 77 aa overlap. 39.7% identity to HP1030. Contains Pfam match to entry PF01052 SPOA_protein, Surface presentation of antigens (SPOA) protein, score 52.80, [...]
    
   0.769
nadK
Putative inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
 
  
 0.720
Cj0230c
Putative transferase protein; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.
  
 
 0.671
coaD
Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family.
  
 
 0.665
Cj0809c
Putative hydrolase; Original (2000) note: Cj0809c, possible hydrolase,len: 198 aa; similar to many hypothetical proteins belonging to the glyoxalase II family e.g. YQGX_BACSU (211 aa), fasta scores; opt: 289 z-score: 365.7 E(): 4.5e-13,32.8% identity in 204 aa overlap. 44.3% identity to HP0813. Contains Pfam match to entry PF00753 lactamase_B,Metallo-beta-lactamase superfamily; Updated (2006) note: No specific characterisation with acceptable identity scores carried out yet. Putative kept within product function. Functional classification -Misc.
       0.606
Cj0808c
Original (2000) note: Cj0808c, small hydrophobic protein, len: 101 aa; no Hp match; Updated (2006) note: Three probable transmembrane helices predicted by TMHMM2.0. Functional classification -Unknown.
       0.597
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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