node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cj1208 | fmt | Cj1208 | Cj0098 | Putative 5-formyltetrahydrofolate cyclo-ligase family protein; Original (2000) note: Cj1208, unknown, len: 208 aa; similar to hypothetical proteins e.g. YGFA_HAEIN HI0858 (187 aa), fasta scores; opt: 150 z-score: 196.6 E(): 0.0012, 26.8% identity in 164 aa overlap. 27.8% identity to HP0761; Updated (2006) note: One probable transmembrane helix predicted by TMHMM2.0. Pfam domain PF01812 5-formyltetrahydrofolate cyclo-ligase family identified within CDS. Product modified to more specific family member based on motif match. No specific characterisation has been carried out in related bact [...] | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.630 |
Cj1208 | folD | Cj1208 | Cj0855 | Putative 5-formyltetrahydrofolate cyclo-ligase family protein; Original (2000) note: Cj1208, unknown, len: 208 aa; similar to hypothetical proteins e.g. YGFA_HAEIN HI0858 (187 aa), fasta scores; opt: 150 z-score: 196.6 E(): 0.0012, 26.8% identity in 164 aa overlap. 27.8% identity to HP0761; Updated (2006) note: One probable transmembrane helix predicted by TMHMM2.0. Pfam domain PF01812 5-formyltetrahydrofolate cyclo-ligase family identified within CDS. Product modified to more specific family member based on motif match. No specific characterisation has been carried out in related bact [...] | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.835 |
Cj1208 | glyA | Cj1208 | Cj0402 | Putative 5-formyltetrahydrofolate cyclo-ligase family protein; Original (2000) note: Cj1208, unknown, len: 208 aa; similar to hypothetical proteins e.g. YGFA_HAEIN HI0858 (187 aa), fasta scores; opt: 150 z-score: 196.6 E(): 0.0012, 26.8% identity in 164 aa overlap. 27.8% identity to HP0761; Updated (2006) note: One probable transmembrane helix predicted by TMHMM2.0. Pfam domain PF01812 5-formyltetrahydrofolate cyclo-ligase family identified within CDS. Product modified to more specific family member based on motif match. No specific characterisation has been carried out in related bact [...] | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity). | 0.515 |
Cj1208 | purD | Cj1208 | Cj1250 | Putative 5-formyltetrahydrofolate cyclo-ligase family protein; Original (2000) note: Cj1208, unknown, len: 208 aa; similar to hypothetical proteins e.g. YGFA_HAEIN HI0858 (187 aa), fasta scores; opt: 150 z-score: 196.6 E(): 0.0012, 26.8% identity in 164 aa overlap. 27.8% identity to HP0761; Updated (2006) note: One probable transmembrane helix predicted by TMHMM2.0. Pfam domain PF01812 5-formyltetrahydrofolate cyclo-ligase family identified within CDS. Product modified to more specific family member based on motif match. No specific characterisation has been carried out in related bact [...] | Phosphoribosylamine--glycine ligase; Original (2000) note: Cj1250, purD, probable phosphoribosylamine--glycine ligase, len: 416 aa; similar to e.g. PUR2_ECOLI phosphoribosylamine--glycine ligase (EC 6.3.4.13) (429 aa), fasta scores; opt: 981 z-score: 1186.4 E(): 0, 39.3% identity in 428 aa overlap. 38.2% identity to HP1218. Contains Pfam match to entry PF01071 GARS,Phosphoribosylglycinamide synthetase (GARS); Updated (2006) note: Pfam domain PF02844, PF01071,PF02842 and PF02843 Phosphoribosylglycinamide synthetase,N domain, B domain, C domain and ATP-grasp (A) domains were identified w [...] | 0.465 |
Cj1208 | purH | Cj1208 | Cj0953c | Putative 5-formyltetrahydrofolate cyclo-ligase family protein; Original (2000) note: Cj1208, unknown, len: 208 aa; similar to hypothetical proteins e.g. YGFA_HAEIN HI0858 (187 aa), fasta scores; opt: 150 z-score: 196.6 E(): 0.0012, 26.8% identity in 164 aa overlap. 27.8% identity to HP0761; Updated (2006) note: One probable transmembrane helix predicted by TMHMM2.0. Pfam domain PF01812 5-formyltetrahydrofolate cyclo-ligase family identified within CDS. Product modified to more specific family member based on motif match. No specific characterisation has been carried out in related bact [...] | Original (2000) note: Cj0953c, purH,phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase, len: 510 aa; highly similar to many e.g. PUR9_ECOLI phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) / IMP cyclohydrolase (EC 3.5.4.10) (529 aa), fasta scores; opt: 812 z-score: 935.5 E(): 0, 44.6% identity in 529 aa overlap. No Hp match; Updated (2006) note: Pfam domains PF01808 AICARFT/IMPCHase bienzyme and PF02142 MGS-like domain were identified within CDS. Further support given to product function. Characterised in Escherichia coli with acceptabl [...] | 0.504 |
Cj1208 | purN | Cj1208 | Cj0187c | Putative 5-formyltetrahydrofolate cyclo-ligase family protein; Original (2000) note: Cj1208, unknown, len: 208 aa; similar to hypothetical proteins e.g. YGFA_HAEIN HI0858 (187 aa), fasta scores; opt: 150 z-score: 196.6 E(): 0.0012, 26.8% identity in 164 aa overlap. 27.8% identity to HP0761; Updated (2006) note: One probable transmembrane helix predicted by TMHMM2.0. Pfam domain PF01812 5-formyltetrahydrofolate cyclo-ligase family identified within CDS. Product modified to more specific family member based on motif match. No specific characterisation has been carried out in related bact [...] | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.563 |
fliY | folD | Cj0059c | Cj0855 | Original (2000) note: Cj0059c, fliY, probable flagellar motor switch protein, len: 280 aa; similar to e.g. TR:P74928 (EMBL:U36839) Treponema pallidum flagellar motor switch protein fliY (348 aa), fasta scores; opt: 277 z-score: 496.5 E(): 2.1e-20, 26.2% identity in 309 aa overlap. Also similar in C-terminus to FLIN_BORBU flagellar motor switch protein fliN (113 aa), fasta scores; opt: 231 z-score: 362.5 E(): 6.2e-13, 44.2% identity in 77 aa overlap. 39.7% identity to HP1030. Contains Pfam match to entry PF01052 SPOA_protein, Surface presentation of antigens (SPOA) protein, score 52.80, [...] | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.769 |
fmt | Cj1208 | Cj0098 | Cj1208 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Putative 5-formyltetrahydrofolate cyclo-ligase family protein; Original (2000) note: Cj1208, unknown, len: 208 aa; similar to hypothetical proteins e.g. YGFA_HAEIN HI0858 (187 aa), fasta scores; opt: 150 z-score: 196.6 E(): 0.0012, 26.8% identity in 164 aa overlap. 27.8% identity to HP0761; Updated (2006) note: One probable transmembrane helix predicted by TMHMM2.0. Pfam domain PF01812 5-formyltetrahydrofolate cyclo-ligase family identified within CDS. Product modified to more specific family member based on motif match. No specific characterisation has been carried out in related bact [...] | 0.630 |
fmt | folD | Cj0098 | Cj0855 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.893 |
fmt | glyA | Cj0098 | Cj0402 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity). | 0.636 |
fmt | purD | Cj0098 | Cj1250 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Phosphoribosylamine--glycine ligase; Original (2000) note: Cj1250, purD, probable phosphoribosylamine--glycine ligase, len: 416 aa; similar to e.g. PUR2_ECOLI phosphoribosylamine--glycine ligase (EC 6.3.4.13) (429 aa), fasta scores; opt: 981 z-score: 1186.4 E(): 0, 39.3% identity in 428 aa overlap. 38.2% identity to HP1218. Contains Pfam match to entry PF01071 GARS,Phosphoribosylglycinamide synthetase (GARS); Updated (2006) note: Pfam domain PF02844, PF01071,PF02842 and PF02843 Phosphoribosylglycinamide synthetase,N domain, B domain, C domain and ATP-grasp (A) domains were identified w [...] | 0.588 |
fmt | purH | Cj0098 | Cj0953c | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Original (2000) note: Cj0953c, purH,phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase, len: 510 aa; highly similar to many e.g. PUR9_ECOLI phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) / IMP cyclohydrolase (EC 3.5.4.10) (529 aa), fasta scores; opt: 812 z-score: 935.5 E(): 0, 44.6% identity in 529 aa overlap. No Hp match; Updated (2006) note: Pfam domains PF01808 AICARFT/IMPCHase bienzyme and PF02142 MGS-like domain were identified within CDS. Further support given to product function. Characterised in Escherichia coli with acceptabl [...] | 0.636 |
fmt | purN | Cj0098 | Cj0187c | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.652 |
fmt | purU | Cj0098 | Cj0790 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.462 |
folD | Cj1208 | Cj0855 | Cj1208 | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Putative 5-formyltetrahydrofolate cyclo-ligase family protein; Original (2000) note: Cj1208, unknown, len: 208 aa; similar to hypothetical proteins e.g. YGFA_HAEIN HI0858 (187 aa), fasta scores; opt: 150 z-score: 196.6 E(): 0.0012, 26.8% identity in 164 aa overlap. 27.8% identity to HP0761; Updated (2006) note: One probable transmembrane helix predicted by TMHMM2.0. Pfam domain PF01812 5-formyltetrahydrofolate cyclo-ligase family identified within CDS. Product modified to more specific family member based on motif match. No specific characterisation has been carried out in related bact [...] | 0.835 |
folD | fliY | Cj0855 | Cj0059c | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Original (2000) note: Cj0059c, fliY, probable flagellar motor switch protein, len: 280 aa; similar to e.g. TR:P74928 (EMBL:U36839) Treponema pallidum flagellar motor switch protein fliY (348 aa), fasta scores; opt: 277 z-score: 496.5 E(): 2.1e-20, 26.2% identity in 309 aa overlap. Also similar in C-terminus to FLIN_BORBU flagellar motor switch protein fliN (113 aa), fasta scores; opt: 231 z-score: 362.5 E(): 6.2e-13, 44.2% identity in 77 aa overlap. 39.7% identity to HP1030. Contains Pfam match to entry PF01052 SPOA_protein, Surface presentation of antigens (SPOA) protein, score 52.80, [...] | 0.769 |
folD | fmt | Cj0855 | Cj0098 | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.893 |
folD | glyA | Cj0855 | Cj0402 | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity). | 0.904 |
folD | lepP | Cj0855 | Cj0856 | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Signal peptidase I; Original (2000) note: Cj0856, lepP, probable signal peptidase I, len: 282 aa; similar to many e.g. LEP_ECOLI signal peptidase I (EC 3.4.21.89) (324 aa), fasta scores; opt: 339 z-score: 395.2 E(): 1e-14, 33.7% identity in 270 aa overlap. 46.2% identity to HP0576. Contains PS00761 Signal peptidases I signature 3 and Pfam match to entry PF00461 signal_pept_I, Signal peptidases I; Updated (2006) note: Pfam domain PF00717 Peptidase S24-like identified within CDS. Also, one probable transmembrane helix predicted by TMHMM2.0. Further support given to product function. Char [...] | 0.851 |
folD | purA | Cj0855 | Cj1498c | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.770 |