STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
folDMethylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (282 aa)    
Predicted Functional Partners:
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
 
 
 0.908
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity).
  
 0.904
fmt
methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.
 
 
 0.893
purH
Original (2000) note: Cj0953c, purH,phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase, len: 510 aa; highly similar to many e.g. PUR9_ECOLI phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) / IMP cyclohydrolase (EC 3.5.4.10) (529 aa), fasta scores; opt: 812 z-score: 935.5 E(): 0, 44.6% identity in 529 aa overlap. No Hp match; Updated (2006) note: Pfam domains PF01808 AICARFT/IMPCHase bienzyme and PF02142 MGS-like domain were identified within CDS. Further support given to product function. Characterised in Escherichia coli with acceptabl [...]
  
 
 0.889
purU
Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).
 
 
 0.866
lepP
Signal peptidase I; Original (2000) note: Cj0856, lepP, probable signal peptidase I, len: 282 aa; similar to many e.g. LEP_ECOLI signal peptidase I (EC 3.4.21.89) (324 aa), fasta scores; opt: 339 z-score: 395.2 E(): 1e-14, 33.7% identity in 270 aa overlap. 46.2% identity to HP0576. Contains PS00761 Signal peptidases I signature 3 and Pfam match to entry PF00461 signal_pept_I, Signal peptidases I; Updated (2006) note: Pfam domain PF00717 Peptidase S24-like identified within CDS. Also, one probable transmembrane helix predicted by TMHMM2.0. Further support given to product function. Char [...]
  
    0.851
Cj1208
Putative 5-formyltetrahydrofolate cyclo-ligase family protein; Original (2000) note: Cj1208, unknown, len: 208 aa; similar to hypothetical proteins e.g. YGFA_HAEIN HI0858 (187 aa), fasta scores; opt: 150 z-score: 196.6 E(): 0.0012, 26.8% identity in 164 aa overlap. 27.8% identity to HP0761; Updated (2006) note: One probable transmembrane helix predicted by TMHMM2.0. Pfam domain PF01812 5-formyltetrahydrofolate cyclo-ligase family identified within CDS. Product modified to more specific family member based on motif match. No specific characterisation has been carried out in related bact [...]
  
 
 0.835
purD
Phosphoribosylamine--glycine ligase; Original (2000) note: Cj1250, purD, probable phosphoribosylamine--glycine ligase, len: 416 aa; similar to e.g. PUR2_ECOLI phosphoribosylamine--glycine ligase (EC 6.3.4.13) (429 aa), fasta scores; opt: 981 z-score: 1186.4 E(): 0, 39.3% identity in 428 aa overlap. 38.2% identity to HP1218. Contains Pfam match to entry PF01071 GARS,Phosphoribosylglycinamide synthetase (GARS); Updated (2006) note: Pfam domain PF02844, PF01071,PF02842 and PF02843 Phosphoribosylglycinamide synthetase,N domain, B domain, C domain and ATP-grasp (A) domains were identified w [...]
  
 
 0.801
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
  
 0.770
fliY
Original (2000) note: Cj0059c, fliY, probable flagellar motor switch protein, len: 280 aa; similar to e.g. TR:P74928 (EMBL:U36839) Treponema pallidum flagellar motor switch protein fliY (348 aa), fasta scores; opt: 277 z-score: 496.5 E(): 2.1e-20, 26.2% identity in 309 aa overlap. Also similar in C-terminus to FLIN_BORBU flagellar motor switch protein fliN (113 aa), fasta scores; opt: 231 z-score: 362.5 E(): 6.2e-13, 44.2% identity in 77 aa overlap. 39.7% identity to HP1030. Contains Pfam match to entry PF01052 SPOA_protein, Surface presentation of antigens (SPOA) protein, score 52.80, [...]
    
   0.769
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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