STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pckAPhosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (524 aa)    
Predicted Functional Partners:
pycB
Original (2000) note: Cj0933c, pycB, possible possible pyruvate carboxylase B subunit, len: 599 aa; similar to TR:O27179 (EMBL:AE000942) Methanobacterium thermoautotrophicum characterised pyruvate carboxylase B (EC 6.4.1.1) (568 aa), fasta scores; opt: 425 z-score: 482.7 E(): 1.4e-19, 29.1% identity in 601 aa overlap. Also similar to other biotin-requiring decarboxlases e.g. DCOA_SALTY oxaloacetate decarboxylase alpha chain (590 aa), fasta scores; opt: 515 z-score: 584.5 E(): 2.9e-25,27.3% identity in 605 aa overlap, and C-terminus of PYC1_YEAST pyruvate carboxylase 1 (1178 aa), fasta [...]
  
 
 0.981
Cj1476c
Original (2000) note: Cj1476c, probable pyruvate-flavodoxin oxidoreductase, len: 1186 aa; highly similar to many e.g. NIFJ_ECOLI probable pyruvate-flavodoxin oxidoreductase (1174 aa), fasta scores; opt: 3586 z-score: 3799.5 E(): 0, 47.2% identity in 1193 aa overlap. N-term has 28.6% identity to HP1110,C-term has 29.7% identity to HP1111. Contains 2x PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature,and Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains; Updated (2006) note: Pfam domains PF02775 Thiamine pyrophosphate enzy [...]
  
 
 0.904
argH
Argininosuccinate lyase; Original (2000) note: Cj0931c, argH,argininosuccinate lyase, len: 460 aa; 97.4% identical to ARLY_CAMJE argininosuccinate lyase (EC 4.3.2.1) (459 aa),and highly similar to many e.g. ARLY_CANAL argininosuccinate lyase (EC 4.3.2.1) (468 aa), fasta scores; opt: 1337 z-score: 1518.4 E(): 0, 44.7% identity in 459 aa overlap. No Hp ortholog. Contains PS00163 Fumarate lyases signature, and Pfam match to entry PF00206 lyase_1, Lyases; Updated (2006) note: Characterised in Campylobacter jejuni, so putative not added to product function. Functional classification - Amino [...]
  
 
  0.896
gltB
Original (2000) note: Cj0007, gltB, probable glutamate synthase (NADPH) large subunit, len: 1496 aa; similar to many e.g. GLTB_ECOLI glutamate synthase (NADPH) large chain (1517 aa), fasta scores; opt: 3846 z-score: 3828.3 E(): 0, 42.5% identity in 1488 aa overlap. No Hp match; Updated (2006) note: Pfam domains PF00310 Glutamine amidotransferases class-II, PF04898 Glutamate synthase central domain, PF01645 Conserved region in glutamate synthase and PF01493 GXGXG motif were all identified within CDS. Further support given to product function. Characterised within Bacillus subtilis with [...]
   
 
 0.866
eno
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
   
 
 0.864
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily.
   
 
 0.831
aspA
Original (2000) note: Cj0087, aspA, aspartate ammonia-lyase, len: 468 aa; similar to many e.g.ASPA_ECOLI aspartate ammonia-lyase (EC 4.3.1.1) (ASPAR (478 aa),fasta scores; opt: 1853 z-score: 2526.1 E(): 0, 58.2% identity in 466 aa overlap, 67.5% identity to HP0649. Contains PS00163 Fumarate lyases signature and Pfam match to entry PF00206 lyase_1, Lyases, score 615.50, E-value 3.1e-181; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. Thus,putative not added to product function. Functional classification - Central intermediary metabolism -Gener [...]
   
 
 0.815
gapA
Original (2000) note: Cj1403c, gapA, glyceraldehyde 3-phosphate dehydrogenase, len: 332 aa; similar to e.g. G3P1_BACSU glyceraldehyde 3-phosphate dehydrogenase 1 (334 aa), fasta scores; opt: 1070 z-score: 1216.4 E(): 0, 50.3% identity in 332 aa overlap. 45.6% identity to HP1346 and 46.7% identity to HP0921. Contains Pfam match to entry PF00044 gpdh, glyceraldehyde 3-phosphate dehydrogenases,and PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site; Updated (2006) note: Pfam domains PF02800 and PF00044 Glyceraldehyde 3-phosphate dehydrogenase,C-terminal and N-terminal were both i [...]
   
  
 0.788
pyk
Pyruvate kinase; Original (2000) note: Cj0392c, pyk, probable pyruvate kinase, len: 480 aa; similar to e.g. KPYK_BACSU pyruvate kinase (EC 2.7.1.40) (585 aa), fasta scores; opt: 1111 z-score: 1494.8 E(): 0, 41.8% identity in 476 aa overlap. No Hp match. Contains PS00659 Glycosyl hydrolases family 5 signature and Pfam match to entry PF00224 PK,Pyruvate kinase, score 523.20, E-value 1.8e-153; Updated (2006) note: Pfam domain PF02887 Pyruvate kinase, alpha/beta domain protein was identified within CDS. Further support given to product function. Characterised within Bacillus subtilis with [...]
   
 
 0.783
flgG2
Flagellar basal-body rod protein; Original (2000) note: Cj0697, flgG2, probable flagellar basal-body rod protein, len: 270 aa; similar to e.g. FLGG_ECOLI flagellar basal-body rod protein FLGG (260 aa), fasta scores; opt: 290 z-score: 318.7 E(): 1.9e-10,28.7% identity in 272 aa overlap. 42.6% identity to HP1092. Also similar to downstream gene Cj0698 (flgG,29.9% identity in 281 aa overlap). Contains PS00588 Flagella basal body rod proteins signature and Pfam match to entry PF00460 flg_bb_rod, Flagella basal body rod proteins; Updated (2006) note: Characterised within Escherichia coli wi [...]
    
   0.769
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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