STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
argFOrnithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline, which is a substrate for argininosuccinate synthetase (ArgG) involved in the final step in arginine biosynthesis. (306 aa)    
Predicted Functional Partners:
argG
Argininosuccinate synthase; Original (2000) note: Cj0665c, argG, probable argininosuccinate synthase, len: 406 aa; highly similar to many e.g. ASSY_RAT argininosuccinate synthase (EC 6.3.4.5) (412 aa), fasta scores; opt: 1191 z-score: 1564.9 E(): 0,48.0% identity in 398 aa overlap, and ASSY_METJA (395 aa),fasta scores; opt: 1080 z-score: 1260.3 E(): 0, 45.8% identity in 391 aa overlap. No Hp match. Contains PS00564 and PS00565 Argininosuccinate synthase signatures 1 and 2,and Pfam match to entry PF00764 Arginosuc_synth,Arginosuccinate synthase; Updated (2006) note: Some characterisatio [...]
 
 
 0.992
carB
Original (2000) note: Cj0279, carB, probable carbamoyl-phosphate synthase large chain, len: 1089 aa; highly similar to many e.g. CARB_ECOLI carbamoyl-phosphate synthase large chain (EC 6.3.5.5) (1072 aa), fasta scores; opt: 3268 z-score: 4517.4 E(): 0, 55.3% identity in 1098 aa overlap. 62.5% identity to HP0919. Contains 2x PS00866 Carbamoyl-phosphate synthase subdomain signature 1, 2x PS00867 Carbamoyl-phosphate synthase subdomain signature 2, and 2x Pfam match to entry PF00289 CPSase_L_chain,Carbamoyl-phosphate synthase (CPSase). Also contains apparent N-terminal signal sequence with [...]
 
 
 0.991
carA
Original (2000) note: Cj1494c, carA, proabable carbamoyl-phosphate synthase small chain, len: 371 aa; similar to many e.g. CARA_ECOLI carbamoyl-phosphate synthase small chain (EC 6.3.5.5) (382 aa), fasta scores; opt: 946 z-score: 1094.4 E(): 0, 40.3% identity in 377 aa overlap. 57.8% identity to HP1237. Contains PS00442 Glutamine amidotransferases class-I active site, Pfam match to entry PF00117 GATase, Glutamine amidotransferases class-I, and Pfam match to entry PF00988 CPSase_sm_chain,Carbamoyl-phosphate synthase small chain, CPSase domain; Updated (2006) note: Characterised wihtin E [...]
 
 
 0.985
argB
Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily.
 
 
 0.979
argH
Argininosuccinate lyase; Original (2000) note: Cj0931c, argH,argininosuccinate lyase, len: 460 aa; 97.4% identical to ARLY_CAMJE argininosuccinate lyase (EC 4.3.2.1) (459 aa),and highly similar to many e.g. ARLY_CANAL argininosuccinate lyase (EC 4.3.2.1) (468 aa), fasta scores; opt: 1337 z-score: 1518.4 E(): 0, 44.7% identity in 459 aa overlap. No Hp ortholog. Contains PS00163 Fumarate lyases signature, and Pfam match to entry PF00206 lyase_1, Lyases; Updated (2006) note: Characterised in Campylobacter jejuni, so putative not added to product function. Functional classification - Amino [...]
 
  
 0.976
argD
Putative acetylornithine/succinyldiaminopimelate aminotransferase; Original (2000) note: Cj0227, argD, probable acetylornithine aminotransferase, len: 395 aa; simlar to many e.g. ARGD_ECOLI acetylornithine aminotransferase (EC 2.6.1.11) (406 aa), fasta scores; opt: 921 z-score: 1042.0 E(): 0, 36.6% identity in 385 aa overlap. No Hp ortholog. Contains Pfam match to entry PF00202 aminotran_3,Aminotransferases class-III pyridoxal-phosphate, score 378.20, E-value 5.1e-131; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. Based on current literature [...]
 
 0.972
argC
Pseudogene (putative IgA protease family protein); Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
  
 
 0.963
dapE
Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily.
 
 
 0.861
hemB
Original (2000) note: Cj0995c, hemB, probable delta-aminolevulinic acid dehydratase, len: 327 aa; similar to many e.g. HEM2_ECOLI delta-aminolevulinic acid dehydratase (EC 4.2.1.24) (323 aa), fasta scores; opt: 1037 z-score: 1214.2 E(): 0, 50.9% identity in 326 aa overlap. 63.7% identity to HP0163. Contains PS00169 Delta-aminolevulinic acid dehydratase active site, and Pfam match to entry PF00490 ALAD, Delta-aminolevulinic acid dehydratase; Updated (2006) note: Characterised in Escherichia coli and Bacillus subtilis with acceptable identity scores, so putative not added to product func [...]
  
    0.829
Cj0993c
Hypothetical protein Cj0993c; Original (2000) note: Cj0993c, unknown, len: 163 aa; 30.1% identity to HP0664. Functional classification -Conserved hypothetical proteins; Belongs to the UPF0763 family.
  
    0.804
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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