STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ileSisoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (917 aa)    
Predicted Functional Partners:
proS
prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...]
   
 0.997
metS
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
 
 0.994
leuS
leucyl-tRNA synthetase; Original (2000) note: Cj1091c, leuS, probable leucyl-tRNA synthetase, len: 809 aa; similar to many e.g. SYL_ECOLI leucyl-tRNA synthetase (EC 6.1.1.4) (860 aa),fasta scores; opt: 1941 z-score: 2210.5 E(): 0, 44.1% identity in 869 aa overlap. 62.7% identity to HP1547. Contains PS00017 ATP/GTP-binding site motif A (P-loop),PS00178 Aminoacyl-transfer RNA synthetases class-I signature, and Pfam match to entry PF00133 tRNA-synt_1,tRNA synthetases class I; Updated (2006) note: Characterised in Escherichia coli with acceptable identity score. Putative not added to produ [...]
 
0.992
argS
arginyl-tRNA synthetase; Original (2000) note: Cj1175c, argS, arginyl-tRNA synthetase, len: 530 aa; similar to many e.g. SYR_BACSU arginyl-tRNA synthetase (EC 6.1.1.19) (556 aa), fasta scores; opt: 1206 z-score: 1360.5 E(): 0, 38.2% identity in 529 aa overlap. 51.1% identity to HP0319. Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature, and Pfam match to entry PF00750 tRNA-synt_1d,tRNA synthetases class I (R); Updated (2006) note: Characterised in Bacillus subtilis with acceptable identity score. Putative not added to product function. Functional classification -Amin [...]
 
 0.992
lysS
lysyl-tRNA synthetase; Original (2000) note: Cj0401, lysS, lysyl-tRNA synthetase, len: 501 aa; 99.8% identical to SYK_CAMJE lysyl-tRNA synthetase (EC 6.1.1.6) (501 aa), and highly similar to many e.g. SYK2_ECOLI lysyl-tRNA synthetase,heat inducible (504 aa, fasta scores; )opt: 1526 z-score: 2137.2 E(): 0, 47.6% identity in 498 aa overlap. 58.8% identity to HP0182. Conatains PS00179 and PS00339 Aminoacyl-transfer RNA synthetases class-II signatures 1 and 2, and Pfam match to entry PF00152 tRNA-synt_2, tRNA synthetases class II, score 690.40, E-value 8.5e-204; Updated (2006) note: Charac [...]
 
 0.989
pheT
Original (2000) note: Cj0896c, pheT, probable phenylalanyl-tRNA synthetase beta chain, len: 773 aa; similar to many e.g. SYFB_ECOLI phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) (795 aa), fasta scores; opt: 585 z-score: 663.2 E(): 1.2e-29, 27.8% identity in 802 aa overlap. 36.0% identity to HP0402; Updated (2006) note: Pfam domains PF03484 tRNA synthetase B5 domain, PF03483 B3/4 domain and PF01588 Putative tRNA binding domain were identified within CDS. Further support given to product function. Characterised in Escherichia coli with marginal identity score. Appropriate motfis [...]
  
 
 0.983
gltX2
glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
  
 0.968
gltX
glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
  
 0.967
valS
valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
 
0.938
alaS
alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
 
 
 0.866
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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