STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rdxAPseudogene (nitroreductase); HMMPfam hit to PF00881, Nitroreductase family,score 1.3e-32. (201 aa)    
Predicted Functional Partners:
aas
Original (2000) note: Cj0938c, aas, probable 2-acylglycerophosphoethanolamine acyltransferase / acyl-acyl carrier protein synthetase, len: 1170 aa; contains 2 domains; C-terminal domain (420 aa to end) is simlar to the bifunctional enzyme AAS_ECOLI 2-acylglycerophosphoethanolamine acyltransferase / acyl-acyl carrier protein synthetase (719 aa), fasta scores; opt: 438 z-score: 471.6 E(): 5.7e-19, 31.0% identity in 762 aa overlap; N-terminal domain contains approx 12 transmembrane domains, and is similar to the hypothetical membrane protein immediately upstreram of the E. coli aas; YGED_ [...]
   
 
 0.892
Cj1301
Hypothetical protein Cj1301; Original (2000) note: Cj1301, unknown, len: 138 aa; similar to a hypothetical protein from Pyrococcus horikoshii TR:O58010 (EMBL:AP000001) PH0272 (136 aa),fasta scores; opt: 137 z-score: 188.8 E(): 0.0032, 32.8% identity in 137 aa overlap. No Hp match; Updated (2006) note: Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Functional classification - Conserved hypothetical proteins; PMID:16573682, PMID:12781527.
   
  
 0.653
ribA
GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the N-terminal section; belongs to the DHBP synthase family.
    
 
 0.618
Cj0519
Putative rhodanese-like domain protein; Original (2000) note: Cj0519, unknown, len: 105 aa; similar to hypothetical proteins e.g. TR:E1342888 (EMBL:AJ235272) Rickettsia prowazekii RP600 (123 aa),fasta scores; opt: 151 z-score: 214.9 E(): 0.00011, 41.6% identity in 89 aa overlap. 34.3% identity to HP1223; Updated (2006) note: Prosite domain PS50206 RHODANESE_3, Rhodanese domain profile also identified within CDS. Rhodanese, a sulphurtransferase involved in cyanide detoxification shares evolutionary relationship with a large family of proteins. This domain is found as a single copy in ot [...]
 
 
 0.586
moaD
Original (2000) note: Cj1517, moaD, possible molybdopterin converting factor, subunit 1, len: 73 aa; similar to many predicted moaD genes, e.g. TR:O31706 (EMBL:AF012285) Bacillus subtilis molybdopterin converting factor (subunit 1) (77 aa), fasta scores; opt: 111 z-score: 167.7 E(): 0.051, 30.5% identity in 59 aa overlap, and weakly similar to MOAD_ECOLI molybdopterin [mpt] converting factor, subunit 1 (81 aa), fasta scores; opt: 81 z-score: 127.5 E(): 8.8, 38.5% identity in 26 aa overlap. 61.6% identity to HP0801; Updated (2006) note: Pfam domain PF02597 ThiS family identified within [...]
   
 
 0.575
rnhA
Ribonuclease HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
    
 0.547
ribF
Original (2000) note: Cj0589, ribF, possible riboflavin kinase/FMN adenylyltransferase, len: 284 aa; simlar to e.g. RIBF_CORAM riboflavin kinase (EC 2.7.1.26); Belongs to the ribF family.
    
 0.540
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
     
 0.514
pgsA
Original (2000) note: Cj1067, pgsA, probable CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, len: 201 aa; similar to many e.g. PGSA_ECOLI CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5) (181 aa), fasta scores; opt: 320 z-score: 405.9 E(): 2.6e-15, 35.8% identity in 176 aa overlap. 43.9% identity to HP1016. Contains PS00379 CDP-alcohol phosphatidyltransferases signature, and Pfam match to entry PF01066 CDP-OH_P_transf, CDP-alcohol phosphatidyltransferase; Updated (2006) note: Four probable transmembrane helices predicted by TMHMM2.0. C [...]
  
    0.511
prsA
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
 
   0.507
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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