node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
pglA | pglB | Cj1125c | Cj1126c | GalNAc transferase; Adds the first GalNAc residue on to the isoprenoid-linked bacillosamine (2,4-diacetamido-2,4,6-trideoxyglucose) carrier in the N- linked protein glycosylation pathway. Acts first on the undecaprenylpyrophosphate-linked bacillosamine (Und-PP-Bac) substrate to yield the disaccharide; Belongs to the glycosyltransferase group 1 family. | Oligosaccharide transferase to N-glycosylate proteins; Oligosaccharyl transferase (OST) that catalyzes the initial transfer of a defined glycan (GalNAc(2)GlcGalNAc(3)Bac(NAc)(2) in eubacteria, where Bac(NAc)(2) is di-N-acetyl bacillosamine) from the lipid carrier undecaprenol-pyrophosphate to an asparagine residue within an Asp/Glu-Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. Belongs to the STT3 family. | 0.925 |
pglA | pglC | Cj1125c | Cj1124c | GalNAc transferase; Adds the first GalNAc residue on to the isoprenoid-linked bacillosamine (2,4-diacetamido-2,4,6-trideoxyglucose) carrier in the N- linked protein glycosylation pathway. Acts first on the undecaprenylpyrophosphate-linked bacillosamine (Und-PP-Bac) substrate to yield the disaccharide; Belongs to the glycosyltransferase group 1 family. | Galactosyltransferase; Glycosyl-1-phosphate transferase that mediates the first step in the biosynthesis of the undecaprenyl-linked heptasaccharide donor in the N-linked protein glycosylation pathway. Catalyzes the linking of uridine 5'-diphosphobacillosamine (UDP-Bac) to undecaprenyl phosphate to create the first membrane-associated intermediate undecaprenylpyrophosphate-linked Bac (Und-PP-Bac). Belongs to the bacterial sugar transferase family. | 0.988 |
pglA | pglD | Cj1125c | Cj1123c | GalNAc transferase; Adds the first GalNAc residue on to the isoprenoid-linked bacillosamine (2,4-diacetamido-2,4,6-trideoxyglucose) carrier in the N- linked protein glycosylation pathway. Acts first on the undecaprenylpyrophosphate-linked bacillosamine (Und-PP-Bac) substrate to yield the disaccharide; Belongs to the glycosyltransferase group 1 family. | Acetyltransferase; Acetyltransferase that modifies the UDP-4-amino-sugar to form UDP-N,N'-diacetylbacillosamine in the N-linked protein glycosylation pathway; Belongs to the transferase hexapeptide repeat family. | 0.932 |
pglA | pglE | Cj1125c | Cj1121c | GalNAc transferase; Adds the first GalNAc residue on to the isoprenoid-linked bacillosamine (2,4-diacetamido-2,4,6-trideoxyglucose) carrier in the N- linked protein glycosylation pathway. Acts first on the undecaprenylpyrophosphate-linked bacillosamine (Und-PP-Bac) substrate to yield the disaccharide; Belongs to the glycosyltransferase group 1 family. | UDP-4-keto-6-deoxy-GlcNAc C4 aminotransferase; Aminotransferase involved in the bacillosamine biosynthesis pathway by producing UDP-4-amino-4,6-dideoxy-alpha-D-GlcNAc (UDP-2- acetamido-4-amino-2,4,6-trideoxy-alpha-D-glucopyranose), a precursor used in the production of the glycan component 2,4-diacetamido-2,4,6- trideoxy-alpha-D-glucopyranose. Required for host colonization and virulence. Involved in the N-linked protein glycosylation pathway. Belongs to the DegT/DnrJ/EryC1 family. | 0.865 |
pglA | pglF | Cj1125c | Cj1120c | GalNAc transferase; Adds the first GalNAc residue on to the isoprenoid-linked bacillosamine (2,4-diacetamido-2,4,6-trideoxyglucose) carrier in the N- linked protein glycosylation pathway. Acts first on the undecaprenylpyrophosphate-linked bacillosamine (Und-PP-Bac) substrate to yield the disaccharide; Belongs to the glycosyltransferase group 1 family. | UDP-GlcNAc C4,6 dehydratase; C6 dehydratase involved in the bacillosamine biosynthesis pathway by generating UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-4- hexulose from UDP-N-acetyl-alpha-D-glucosamine. Involved in the N- linked protein glycosylation pathway. | 0.905 |
pglA | pglG | Cj1125c | Cj1119c | GalNAc transferase; Adds the first GalNAc residue on to the isoprenoid-linked bacillosamine (2,4-diacetamido-2,4,6-trideoxyglucose) carrier in the N- linked protein glycosylation pathway. Acts first on the undecaprenylpyrophosphate-linked bacillosamine (Und-PP-Bac) substrate to yield the disaccharide; Belongs to the glycosyltransferase group 1 family. | Putative integral membrane protein; Original (2000) note: Cj1119c, wlaM, pglG, probable integral membrane protein, len: 297 aa; 99.3% identical to TR:O86160 (EMBL:Y11648) C. jejuni 81116 wlaM (297 aa). Also contains short section of similarity to TR:Q56633 (EMBL:L25660) Vibrio cholerae accessory colonization factor (ACFB) (626 aa), fasta scores; opt: 165 z-score: 202.6 E(): 0.00055, 34.0% identity in 103 aa overlap. 37.6% identity to HP0158; Updated (2006) note: Four probable transmembrane helices predicted by TMHMM2.0. Characterised in Campylobacter jejuni. The putative integral membr [...] | 0.824 |
pglA | pglH | Cj1125c | Cj1129c | GalNAc transferase; Adds the first GalNAc residue on to the isoprenoid-linked bacillosamine (2,4-diacetamido-2,4,6-trideoxyglucose) carrier in the N- linked protein glycosylation pathway. Acts first on the undecaprenylpyrophosphate-linked bacillosamine (Und-PP-Bac) substrate to yield the disaccharide; Belongs to the glycosyltransferase group 1 family. | GalNAc transferase/polymerase; Processive glycosyltransferase that is part of the biosynthetic pathway of the lipid-linked oligosaccharide (LLO) that serves as the glycan donor in bacterial protein N-glycosylation. Catalyzes the transfer of exactly three alpha-(1->4)-N- acetylgalactosamine (GalNAc) units to the growing LLO precursor, GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-undecaprenyl. Cannot accept UDP- GlcNAc as substrate. | 0.896 |
pglA | pglI | Cj1125c | Cj1128c | GalNAc transferase; Adds the first GalNAc residue on to the isoprenoid-linked bacillosamine (2,4-diacetamido-2,4,6-trideoxyglucose) carrier in the N- linked protein glycosylation pathway. Acts first on the undecaprenylpyrophosphate-linked bacillosamine (Und-PP-Bac) substrate to yield the disaccharide; Belongs to the glycosyltransferase group 1 family. | Glucosyl transferase; Glucosyltransferase that adds he final branching glucose to complete the final heptasaccharide structure in the N-linked protein glycosylation pathway; Belongs to the glycosyltransferase 2 family. | 0.951 |
pglA | pglJ | Cj1125c | Cj1127c | GalNAc transferase; Adds the first GalNAc residue on to the isoprenoid-linked bacillosamine (2,4-diacetamido-2,4,6-trideoxyglucose) carrier in the N- linked protein glycosylation pathway. Acts first on the undecaprenylpyrophosphate-linked bacillosamine (Und-PP-Bac) substrate to yield the disaccharide; Belongs to the glycosyltransferase group 1 family. | GalNAc transferase; Adds a GalNAc residue on to the Und-PP-Bac2,4diNAc-GalNAc disaccharide in the N-linked protein glycosylation pathway. Transfers the third sugar in the heptasaccharide biosynthesis. | 0.975 |
pglA | pglK | Cj1125c | Cj1130c | GalNAc transferase; Adds the first GalNAc residue on to the isoprenoid-linked bacillosamine (2,4-diacetamido-2,4,6-trideoxyglucose) carrier in the N- linked protein glycosylation pathway. Acts first on the undecaprenylpyrophosphate-linked bacillosamine (Und-PP-Bac) substrate to yield the disaccharide; Belongs to the glycosyltransferase group 1 family. | Flippase; Mediates the ATP-dependent translocation of the undecaprenylpyrophosphate-linked heptasaccharide intermediate across the cell membrane; this is an essential step during the N-linked protein glycosylation pathway. Transport across the membrane is effected via ATP-driven conformation changes. Most likely, only the polar and charged part of the glycolipid enter the substrate-binding cavity, and the lipid tail remains exposed to the membrane lipids during the transmembrane flipping process. | 0.949 |
pglB | pglA | Cj1126c | Cj1125c | Oligosaccharide transferase to N-glycosylate proteins; Oligosaccharyl transferase (OST) that catalyzes the initial transfer of a defined glycan (GalNAc(2)GlcGalNAc(3)Bac(NAc)(2) in eubacteria, where Bac(NAc)(2) is di-N-acetyl bacillosamine) from the lipid carrier undecaprenol-pyrophosphate to an asparagine residue within an Asp/Glu-Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. Belongs to the STT3 family. | GalNAc transferase; Adds the first GalNAc residue on to the isoprenoid-linked bacillosamine (2,4-diacetamido-2,4,6-trideoxyglucose) carrier in the N- linked protein glycosylation pathway. Acts first on the undecaprenylpyrophosphate-linked bacillosamine (Und-PP-Bac) substrate to yield the disaccharide; Belongs to the glycosyltransferase group 1 family. | 0.925 |
pglB | pglC | Cj1126c | Cj1124c | Oligosaccharide transferase to N-glycosylate proteins; Oligosaccharyl transferase (OST) that catalyzes the initial transfer of a defined glycan (GalNAc(2)GlcGalNAc(3)Bac(NAc)(2) in eubacteria, where Bac(NAc)(2) is di-N-acetyl bacillosamine) from the lipid carrier undecaprenol-pyrophosphate to an asparagine residue within an Asp/Glu-Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. Belongs to the STT3 family. | Galactosyltransferase; Glycosyl-1-phosphate transferase that mediates the first step in the biosynthesis of the undecaprenyl-linked heptasaccharide donor in the N-linked protein glycosylation pathway. Catalyzes the linking of uridine 5'-diphosphobacillosamine (UDP-Bac) to undecaprenyl phosphate to create the first membrane-associated intermediate undecaprenylpyrophosphate-linked Bac (Und-PP-Bac). Belongs to the bacterial sugar transferase family. | 0.926 |
pglB | pglD | Cj1126c | Cj1123c | Oligosaccharide transferase to N-glycosylate proteins; Oligosaccharyl transferase (OST) that catalyzes the initial transfer of a defined glycan (GalNAc(2)GlcGalNAc(3)Bac(NAc)(2) in eubacteria, where Bac(NAc)(2) is di-N-acetyl bacillosamine) from the lipid carrier undecaprenol-pyrophosphate to an asparagine residue within an Asp/Glu-Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. Belongs to the STT3 family. | Acetyltransferase; Acetyltransferase that modifies the UDP-4-amino-sugar to form UDP-N,N'-diacetylbacillosamine in the N-linked protein glycosylation pathway; Belongs to the transferase hexapeptide repeat family. | 0.910 |
pglB | pglE | Cj1126c | Cj1121c | Oligosaccharide transferase to N-glycosylate proteins; Oligosaccharyl transferase (OST) that catalyzes the initial transfer of a defined glycan (GalNAc(2)GlcGalNAc(3)Bac(NAc)(2) in eubacteria, where Bac(NAc)(2) is di-N-acetyl bacillosamine) from the lipid carrier undecaprenol-pyrophosphate to an asparagine residue within an Asp/Glu-Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. Belongs to the STT3 family. | UDP-4-keto-6-deoxy-GlcNAc C4 aminotransferase; Aminotransferase involved in the bacillosamine biosynthesis pathway by producing UDP-4-amino-4,6-dideoxy-alpha-D-GlcNAc (UDP-2- acetamido-4-amino-2,4,6-trideoxy-alpha-D-glucopyranose), a precursor used in the production of the glycan component 2,4-diacetamido-2,4,6- trideoxy-alpha-D-glucopyranose. Required for host colonization and virulence. Involved in the N-linked protein glycosylation pathway. Belongs to the DegT/DnrJ/EryC1 family. | 0.775 |
pglB | pglF | Cj1126c | Cj1120c | Oligosaccharide transferase to N-glycosylate proteins; Oligosaccharyl transferase (OST) that catalyzes the initial transfer of a defined glycan (GalNAc(2)GlcGalNAc(3)Bac(NAc)(2) in eubacteria, where Bac(NAc)(2) is di-N-acetyl bacillosamine) from the lipid carrier undecaprenol-pyrophosphate to an asparagine residue within an Asp/Glu-Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. Belongs to the STT3 family. | UDP-GlcNAc C4,6 dehydratase; C6 dehydratase involved in the bacillosamine biosynthesis pathway by generating UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-4- hexulose from UDP-N-acetyl-alpha-D-glucosamine. Involved in the N- linked protein glycosylation pathway. | 0.823 |
pglB | pglG | Cj1126c | Cj1119c | Oligosaccharide transferase to N-glycosylate proteins; Oligosaccharyl transferase (OST) that catalyzes the initial transfer of a defined glycan (GalNAc(2)GlcGalNAc(3)Bac(NAc)(2) in eubacteria, where Bac(NAc)(2) is di-N-acetyl bacillosamine) from the lipid carrier undecaprenol-pyrophosphate to an asparagine residue within an Asp/Glu-Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. Belongs to the STT3 family. | Putative integral membrane protein; Original (2000) note: Cj1119c, wlaM, pglG, probable integral membrane protein, len: 297 aa; 99.3% identical to TR:O86160 (EMBL:Y11648) C. jejuni 81116 wlaM (297 aa). Also contains short section of similarity to TR:Q56633 (EMBL:L25660) Vibrio cholerae accessory colonization factor (ACFB) (626 aa), fasta scores; opt: 165 z-score: 202.6 E(): 0.00055, 34.0% identity in 103 aa overlap. 37.6% identity to HP0158; Updated (2006) note: Four probable transmembrane helices predicted by TMHMM2.0. Characterised in Campylobacter jejuni. The putative integral membr [...] | 0.731 |
pglB | pglH | Cj1126c | Cj1129c | Oligosaccharide transferase to N-glycosylate proteins; Oligosaccharyl transferase (OST) that catalyzes the initial transfer of a defined glycan (GalNAc(2)GlcGalNAc(3)Bac(NAc)(2) in eubacteria, where Bac(NAc)(2) is di-N-acetyl bacillosamine) from the lipid carrier undecaprenol-pyrophosphate to an asparagine residue within an Asp/Glu-Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. Belongs to the STT3 family. | GalNAc transferase/polymerase; Processive glycosyltransferase that is part of the biosynthetic pathway of the lipid-linked oligosaccharide (LLO) that serves as the glycan donor in bacterial protein N-glycosylation. Catalyzes the transfer of exactly three alpha-(1->4)-N- acetylgalactosamine (GalNAc) units to the growing LLO precursor, GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-undecaprenyl. Cannot accept UDP- GlcNAc as substrate. | 0.920 |
pglB | pglI | Cj1126c | Cj1128c | Oligosaccharide transferase to N-glycosylate proteins; Oligosaccharyl transferase (OST) that catalyzes the initial transfer of a defined glycan (GalNAc(2)GlcGalNAc(3)Bac(NAc)(2) in eubacteria, where Bac(NAc)(2) is di-N-acetyl bacillosamine) from the lipid carrier undecaprenol-pyrophosphate to an asparagine residue within an Asp/Glu-Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. Belongs to the STT3 family. | Glucosyl transferase; Glucosyltransferase that adds he final branching glucose to complete the final heptasaccharide structure in the N-linked protein glycosylation pathway; Belongs to the glycosyltransferase 2 family. | 0.928 |
pglB | pglJ | Cj1126c | Cj1127c | Oligosaccharide transferase to N-glycosylate proteins; Oligosaccharyl transferase (OST) that catalyzes the initial transfer of a defined glycan (GalNAc(2)GlcGalNAc(3)Bac(NAc)(2) in eubacteria, where Bac(NAc)(2) is di-N-acetyl bacillosamine) from the lipid carrier undecaprenol-pyrophosphate to an asparagine residue within an Asp/Glu-Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. Belongs to the STT3 family. | GalNAc transferase; Adds a GalNAc residue on to the Und-PP-Bac2,4diNAc-GalNAc disaccharide in the N-linked protein glycosylation pathway. Transfers the third sugar in the heptasaccharide biosynthesis. | 0.920 |
pglB | pglK | Cj1126c | Cj1130c | Oligosaccharide transferase to N-glycosylate proteins; Oligosaccharyl transferase (OST) that catalyzes the initial transfer of a defined glycan (GalNAc(2)GlcGalNAc(3)Bac(NAc)(2) in eubacteria, where Bac(NAc)(2) is di-N-acetyl bacillosamine) from the lipid carrier undecaprenol-pyrophosphate to an asparagine residue within an Asp/Glu-Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. Belongs to the STT3 family. | Flippase; Mediates the ATP-dependent translocation of the undecaprenylpyrophosphate-linked heptasaccharide intermediate across the cell membrane; this is an essential step during the N-linked protein glycosylation pathway. Transport across the membrane is effected via ATP-driven conformation changes. Most likely, only the polar and charged part of the glycolipid enter the substrate-binding cavity, and the lipid tail remains exposed to the membrane lipids during the transmembrane flipping process. | 0.916 |