STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
pglKFlippase; Mediates the ATP-dependent translocation of the undecaprenylpyrophosphate-linked heptasaccharide intermediate across the cell membrane; this is an essential step during the N-linked protein glycosylation pathway. Transport across the membrane is effected via ATP-driven conformation changes. Most likely, only the polar and charged part of the glycolipid enter the substrate-binding cavity, and the lipid tail remains exposed to the membrane lipids during the transmembrane flipping process. (564 aa)    
Predicted Functional Partners:
pglA
GalNAc transferase; Adds the first GalNAc residue on to the isoprenoid-linked bacillosamine (2,4-diacetamido-2,4,6-trideoxyglucose) carrier in the N- linked protein glycosylation pathway. Acts first on the undecaprenylpyrophosphate-linked bacillosamine (Und-PP-Bac) substrate to yield the disaccharide; Belongs to the glycosyltransferase group 1 family.
 
 0.949
pglJ
GalNAc transferase; Adds a GalNAc residue on to the Und-PP-Bac2,4diNAc-GalNAc disaccharide in the N-linked protein glycosylation pathway. Transfers the third sugar in the heptasaccharide biosynthesis.
 
 0.949
pglH
GalNAc transferase/polymerase; Processive glycosyltransferase that is part of the biosynthetic pathway of the lipid-linked oligosaccharide (LLO) that serves as the glycan donor in bacterial protein N-glycosylation. Catalyzes the transfer of exactly three alpha-(1->4)-N- acetylgalactosamine (GalNAc) units to the growing LLO precursor, GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-undecaprenyl. Cannot accept UDP- GlcNAc as substrate.
  
 0.940
Cj0377
Putative AAA family ATPase; Original (2000) note: Cj0377, probable ATPase, len: 570 aa; weak similarity to many members of the AAA family e.g. TR:O28182 (EMBL:O28182) cell division control protein 48 (Archaeoglobus fulgidus AF2098) (811 aa), fasta scores; opt: 341 z-score: 312.6 E(): 3.7e-10, 26.4% identity in 435 aa overlap. No Hp match. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and Pfam match to entry PF00004 AAA, ATPases associated with various cellular activities (AAA), score 106.20, E-value 6.3e-28; Updated (2006) note: Probable changed to putative. No specific charac [...]
 
 
 0.928
pglC
Galactosyltransferase; Glycosyl-1-phosphate transferase that mediates the first step in the biosynthesis of the undecaprenyl-linked heptasaccharide donor in the N-linked protein glycosylation pathway. Catalyzes the linking of uridine 5'-diphosphobacillosamine (UDP-Bac) to undecaprenyl phosphate to create the first membrane-associated intermediate undecaprenylpyrophosphate-linked Bac (Und-PP-Bac). Belongs to the bacterial sugar transferase family.
  
  
 0.927
pglI
Glucosyl transferase; Glucosyltransferase that adds he final branching glucose to complete the final heptasaccharide structure in the N-linked protein glycosylation pathway; Belongs to the glycosyltransferase 2 family.
  
  
 0.920
pglB
Oligosaccharide transferase to N-glycosylate proteins; Oligosaccharyl transferase (OST) that catalyzes the initial transfer of a defined glycan (GalNAc(2)GlcGalNAc(3)Bac(NAc)(2) in eubacteria, where Bac(NAc)(2) is di-N-acetyl bacillosamine) from the lipid carrier undecaprenol-pyrophosphate to an asparagine residue within an Asp/Glu-Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. Belongs to the STT3 family.
   
 
 0.916
pglD
Acetyltransferase; Acetyltransferase that modifies the UDP-4-amino-sugar to form UDP-N,N'-diacetylbacillosamine in the N-linked protein glycosylation pathway; Belongs to the transferase hexapeptide repeat family.
  
  
 0.915
gne
UDP-GlcNAc/Glc 4-epimerase; Original (2000) note: Cj1131c, galE, probable UDP-glucose 4-epimerase, len: 328 aa; 98.2% identical to TR:O86149 (EMBL:Y11648) C. jejuni 81116 galE (328 aa), and similar to e.g. GALE_STRMU UDP-glucose 4-epimerase (EC 5.1.3.2) (333 aa), fasta scores; opt: 887 z-score: 1056.0 E(): 0, 43.7% identity in 327 aa overlap. 50.0% identity to HP0360; Updated (2006) note: Pfam domain PF01370, NAD dependent epimerase/dehydratase family identified within CDS. Characterised within Campylobacter jejuni with recent evidence allowing product function and gene name to be upda [...]
  
 
 0.878
Cj0413
Putative periplasmic protein; Hydrolyzes 6-aminopenicillinic acid and 7- aminocephalosporanic acid (ACA) derivatives.
  
  
  0.849
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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