STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cstIIIAlpha-2,3 sialyltransferase; Original (2000) note: Cj1140, unknown, len: 294 aa; similar to H. influenzae hypothetical protein in lipopolysaccharide biosynthesis gene cluster Y352_HAEIN HI0352 (ORF1) (231 aa), fasta scores; opt: 558 z-score: 672.8 E(): 3.5e-30, 41.5% identity in 229 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF06002 Alpha-2,3-sialyltransferase (CST-I) identified within CDS. Characterisation work carried out within Campylobacter jejuni, so product function modified to new family member. Putative not added to product function. This protein transfers sialic [...] (294 aa)    
Predicted Functional Partners:
neuA1,
Two-domain bifunctional protein (beta-1,4-N-acetylgalactosaminyltransferase/CMP-Neu5Ac synthase); Original (2000) note: Cj1143, neuA1, probable acylneuraminate cytidylyltransferase (CMP-N-acetylneuraminic acid synthetase), len: 536 aa; N-terminus is similar to HP0217 (49.1% identity in 279 aa overlap), C-traminus is similar to NEUA_NEIME acylneuraminate cytidylyltransferase (EC 2.7.7.43) (228 aa), fasta scores; opt: 471 z-score: 550.3 E(): 2.3e-23,39.4% identity in 221 aa overlap, and to Cj1311 (31.6% identity in 215 aa overlap) and Cj1331 (34.7% identity in 219 aa overlap); Updated (2 [...]
  
  
 0.988
neuC1
Putative UDP-N-acetylglucosamine 2-epimerase; Original (2000) note: Cj1142, neuC1, probable N-acetylglucosamine-6-phosphate 2-epimerase/N-acetylglucosamine-6-phosphatase, len: 371 aa; similar to e.g. TR:Q57141 (EMBL:X78068) Neisseria meningitidis putative N-acetylglucosamine-6-phosphate 2-epimerase (EC 5.1.3.-) / N-acetylglucosamine-6-phosphatase (EC 3.1.3.-) (377 aa),fatsta scores; opt: 1029 z-score: 1162.4 E(): 0, 44.0% identity in 377 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF02350 UDP-N-acetylglucosamine 2-epimerase identified within CDS. Further support given to [...]
  
  
 0.985
neuB1
Sialic acid synthase (N-acetylneuraminic acid synthetase); Original (2000) note: Cj1141, neuB1, probable N-acetylneuraminic acid synthetase, len: 343 aa; highly similar to e.g. TR:Q57265 (EMBL:U40740) N-acetylneuraminic acid synthetase (EC 4.1.3.-) (349 aa), fasta scores; opt: 1327 z-score: 1554.1 E(): 0, 59.0% identity in 344 aa overlap. No Hp ortholog. Also similar to Cj1327 (37.1% identity in 329 aa overlap) and Cj1317 (34.4% identity in 340 aa overlap); Updated (2006) note: Pfam domains PF03102 NeuB family and PF01354 Antifreeze-like domain were identified within CDS. Characterisat [...]
  
  
 0.983
wlaN
Beta-1,3 galactosyltransferase; Original (2000) note: Cj1139c, probable galactosyltransferase, len: 303 aa; similar to e.g. TR:O07340 (EMBL:X85787) Streptococcus pneumoniae SS-1,4-galactosyltransferase CPS14J (318 aa), fasta scores; opt: 309 z-score: 362.2 E(): 7.1e-13, 26.1% identity in 249 aa overlap. No Hp match. Contains Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferases. Contains C(8-9) polymorphic region at aa 111. C(8), the consensus, allows translation of the full length protein. C(9) would cause a premature truncation after a further 20 aa; Updated (2006) note: [...]
  
  
 0.969
Cj1137c
Putative glycosyltransferase; Original (2000) note: Cj1137c, unknown, len: 331 aa; similar to hypothetcal proteins in polysaccharide biosynthesis operons e.g. TR:O86892 (EMBL:AJ006986) Streptococcus pneumoniae CAPP33FI protein (322 aa), fasta scores; opt: 295 z-score: 346.5 E(): 5.3e-12, 26.5% identity in 294 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF05704 Capsular polysaccharide synthesis protein identified within CDS. Product function modified to more specific family member. No specific characterisation has been carried out yet. Putative kept within product function [...]
   
  
 0.917
Cj1136
Putative glycosyltransferase; Original (2000) note: Cj1136, probable galactosyltransferase, len: 390 aa; similar to e.g. TR:O07340 (EMBL:X85787) Streptococcus pneumoniae SS-1,4-galactosyltransferase CPS14J (318 aa), fasta scores; opt: 309 z-score: 361.4 E(): 7.8e-13, 29.0% identity in 290 aa overlap. No Hp match. Contains Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferases; Updated (2006) note: Pfam domain PF00535 Glycosyl transferase identified within CDS. Product function updated based on motif match. No specific characterisation has been carried out yet, so putative k [...]
   
  
 0.905
Cj1138
Putative glycosyltransferase; Original (2000) note: Cj1138, probable galactosyltransferase, len: 389 aa; similar to e.g. TR:O07340 (EMBL:X85787) Streptococcus pneumoniae SS-1,4-galactosyltransferase CPS14J (318 aa), fasta scores; opt: 304 z-score: 361.2 E(): 8e-13, 25.8% identity in 383 aa overlap. No Hp match. Contains Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferases; Updated (2006) note: No specific characterisation with acceptable identity score has been carried out yet. Putative kept within product function. Product function modified to more specific family member [...]
   
  
 0.876
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
    
 
 0.858
Cj1144c
Hypothetical protein Cj1144c; Original (2000) note: Cj1144c, unknown, len: 197 aa; no Hp match. Contains C(8-9) polymorphism at aa 15; C(8), the consnsus gives this CDS; C(9) would cause truncation after 4 aa, although a Met at aa 23 would allow translation to re-initiate. C(7) or C(10), although not seen in shotgun, would allow translation from upstream CDS Cj1145c; Original (2000) note: Cj1145c, unknown, len: 105 aa; no Hp match. Contains C(8-9) polymorphism at aa 99; C(8), the consnsus gives this CDS; C(9) would cause truncation after4 aa; C(7) or C(10), although not seen in shotgun [...]
   
    0.819
waaV
Putative glucosyltransferase; Original (2000) note: Cj1146c, waaV, possible glucosyltransferase, len: 274 aa; similar to e.g. TR:O87182 (EMBL:AB017355) Streptococcus agalactiae N-acetylglucosaminyltransferase CPSH (333 aa), fasta scores; opt: 339 z-score: 402.4 E(): 4.1e-15, 31.4% identity in 274 aa overlap. No Hp match. Contains Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferases; Updated (2006) note: Some characterisation within Escherichia coli, however, identity score was marginal. Putative kept within product function. Identifed as part of Campylobacter jejuni lipoo [...]
   
  
 0.809
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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