STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gmhASedoheptulose 7-phosphate isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate; Belongs to the SIS family. GmhA subfamily. (186 aa)    
Predicted Functional Partners:
hldE
D-beta-D-heptose 7-phosphate kinase/D-beta-D-heptose 1-phosphate adenylyltransferase; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the N-terminal section; belongs to the carbohydrate kinase PfkB family.
 
 0.996
gmhB
D,D-heptose 1,7-bisphosphate phosphatase; Converts the D-glycero-alpha-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-alpha-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position; Belongs to the GmhB family.
 
 0.996
hddA
Putative D-glycero-D-manno-heptose 7-phosphate kinase; Original (2000) note: Cj1425c, possible sugar kinase, len: 339 aa; similar to e.g. GAL1_LACHE galactokinase (388 aa), fasta scores; opt: 186 z-score: 227.6 E(): 2.4e-05, 24.3% identity in 371 aa overlap. Contains PS00012 Phosphopantetheine attachment site. No Hp match; Updated (2006) note: Pfam domain PF00288 GHMP kinases putative ATP-binding protein identified within CDS. Further support given to product function. Literature search identified work carried out within Campylobacter jejuni. Not yet fully characterised, so putative ke [...]
 
 0.924
hldD
ADP-glyceromanno-heptose 6-epimerase; Original (2000) note: Cj1151c, waaD, probable ADP-L-glycero-D-manno-heptose-6-epimerase, len: 317 aa; similar to e.g. RFAD_ECOLI ADP-L-glycero-D-manno-heptose-6-epimerase (EC 5.1.3.20) (310 aa), fasta scores; opt: 533 z-score: 600.5 E(): 3.8e-26. 32.9% identity in 319 aa overlap. 48.3% identity to HP0859; Updated (2006) note: Pfam domain PF01370 NAD dependent epimerase/dehydratase family identified within CDS. Further support given to product function. Characterised within Escherichia coli with marginal identity score. Product function has been upd [...]
 
  
 0.876
hisB
Original (2000) note: Cj1599, hisB, probable imidazoleglycerol-phosphate dehydratase/histidinol-phosphatase, len: 352 aa; similar to many e.g. HIS7_ECOLI histidine biosynthesis bifunctional protein HISB [includes: imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) (IGPD); histidinol-phosphatase (EC 3.1.3.15)] (355 aa),fasta scores; opt: 1385 z-score: 1653.6 E(): 0, 56.7% identity in 356 aa overlap. No Hp match. Contains PS00954 and PS00955 Imidazoleglycerol-phosphate dehydratase signatures 1 and 2, and Pfam match to entry PF00475 IGPD,Imidazoleglycerol-phosphate dehydratase; Updated [...]
   
 
 0.800
dnaA
Chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity).
    
 
 0.797
fliH
Original (2000) note: Cj0320, fliH, possible flagellar assembly protein, len: 364 aa; weakly similar to e.g. SW:FLIH_BACSU P23449 probable flagellar assembly protein fliH (208 aa), wublastp scores; E= 6.3e-07, 22% identity in 190 aa overlap. 34.6% identity to HP0353; Updated (2006) note: Characterised within Bacillus subtilis, however, identity score unnacceptable. Putative kept within product function. Functional classification -Surface structures; PMID:1828465.
   
   0.771
fliY
Original (2000) note: Cj0059c, fliY, probable flagellar motor switch protein, len: 280 aa; similar to e.g. TR:P74928 (EMBL:U36839) Treponema pallidum flagellar motor switch protein fliY (348 aa), fasta scores; opt: 277 z-score: 496.5 E(): 2.1e-20, 26.2% identity in 309 aa overlap. Also similar in C-terminus to FLIN_BORBU flagellar motor switch protein fliN (113 aa), fasta scores; opt: 231 z-score: 362.5 E(): 6.2e-13, 44.2% identity in 77 aa overlap. 39.7% identity to HP1030. Contains Pfam match to entry PF01052 SPOA_protein, Surface presentation of antigens (SPOA) protein, score 52.80, [...]
   
   0.769
waaF
Heptosyltransferase II; Original (2000) note: Cj1148, waaF, probable ADP-heptose--LPS heptosyltransferase, len: 319 aa; similar to e.g. TR:Q51063 (EMBL:Z37141) Neisseria gonorrhoeae ADP-heptose:LPS heptosyltransferase II (336 aa), fasta scores; opt: 384 z-score: 447.0 E(): 1.3e-17, 29.7% identity in 333 aa overlap, and RFAF_ECOLI ADP-heptose--LPS heptosyltransferase II (348 aa), fasta scores; opt: 292 z-score: 341.5 E(): 1e-11, 24.1% identity in 348 aa overlap. 37.6% identity to HP1191. Also similar to Cj1133 (24.8% identity in 351 aa overlap). Contains Pfam match to entry PF01075 Hept [...]
 
  
 0.765
waaC
Original (2000) note: Cj1133, waaC, probable lipopolysaccharide heptosyltransferase, len: 342 aa; 98.2% identical to TR:O87585 (EMBL:AF086705) C. jejuni heptosyltransferase WaaC (342 aa), and similar to e.g. RFAC_ECOLI lipopolysaccharide heptosyltransferase-1 (319 aa), fasta scores; opt: 212 z-score: 252.9 E(): 8.6e-07,26.2% identity in 302 aa overlap. 38.5% identity to HP0279. Contains Pfam match to entry PF01075 Heptosyltranf, Heptosyltransferase; Updated (2006) note: Characterised within Campylobacter jejuni. Product function further updated. Putative not added to product function. [...]
 
  
 0.737
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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