STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cj1163cOriginal (2000) note: Cj1163c, possible cation transport protein, len: 316 aa; similar to e.g. CZCD_ALCEU cobalt-zinc-cadmium resistance protein CZCD (316 aa),fasta scores; opt: 609 z-score: 699.8 E(): 1.1e-31, 36.2% identity in 287 aa overlap. No Hp match. Contains His-rich regin at N-terminus. Also similar to Cj0948c (25.7% identity in 280 aa overlap); Updated (2006) note: Pfam domain PF01545 Cation efflux family domain identified within CDS. Also, six probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. Characterisation has been carried ou [...] (316 aa)    
Predicted Functional Partners:
Cj1161c
Original (2000) note: Cj1161c, probable cation-transporting ATPase, len: 699 aa; similar to members of the E1-E2 ATPase family e.g. COPA_HELFE copper-transporting ATPase (732 aa), fasta scores; opt: 1106 z-score: 1124.4 E(): 0, 32.8% identity in 729 aa overlap. 33.2% identity to HP1072. Contains Pfam match to entry PF00403 HMA, Heavy-metal-associated domain containing proteins, 2x Pfam match to entry PF00122 E1-E2_ATPase, and PS00154 E1-E2 ATPases phosphorylation site; Updated (2006) note: Characterisation in more than one bacteria with marginal identity scores. Putative kept within pr [...]
  
  
 0.948
Cj1162c
Putative heavy-metal-associated domain protein; Original (2000) note: Cj1162c, unknown, len: 64 aa; no Hp match; Updated (2006) note: Prosite domain PS50846 HMA_2,Heavy metal transport/detoxification protein within CDS. Product modified to more specific family member based on motif match. No specific characterisation carried out yet,so putative kept within product function. Functional classification - Conserved hypothetical proteins.
     
 0.945
Cj1164c
Hypothetical protein Cj1164c; Original (2000) note: Cj1164c, unknown, len: 87 aa; no Hp match. Contains two Cys pairs; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Functional classification -Unknown.
  
  
 0.828
zupT
Zinc transporter; Mediates zinc uptake. May also transport other divalent cations (By similarity); Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.
 
 0.715
Cj0948c
Putative cation efflux family protein; Original (2000) note: Cj0948c, possible transmembrane transport protein, len: 295 aa; similar to members of the UPF0018 family, e.g. YIIP_ECOLI (300 aa),fasta scores; opt: 564 z-score: 671.3 E(): 4.3e-30, 31.8% identity in 292 aa overlap, and to cation efflux proteins e.g. CZCD_ALCEU cation efflux system protein CZCD (316 aa), fasta scores; opt: 262 z-score: 316.4 E(): 2.5e-10,22.3% identity in 273 aa overlap. No Hp match. Also similar to Cj1163c (24.7% identity in 279 aa overlap); Updated (2006) note: Pfam domain PF01545 Cation efflux family iden [...]
 
 
 
0.612
Cj1160c
Putative membrane protein; Original (2000) note: Cj1160c, small hydrophobic protein, len: 59 aa; no Hp match; Updated (2006) note: One probable transmembrane helix predicted for TMHMM2.0. Also, one signal peptide predicted by SignalP 2.0 HMM. Product function modified to more specific family member. Putative kept within product function. Functional classification - Membranes,lipoproteins and porins.
       0.572
Cj1158c
Original (2000) note: Cj1158c, small hydrophobic protein, len: 75 aa; no Hp match; Updated (2006) note: Two probable transmembrane helices predicted by TMHMM2.0. Similar to hypothetical proteins from other bacteria. Functional classification -Unknown.
  
    0.561
Cj1159c
Original (2000) note: Cj1159c, small hydrophobic protein, len: 40 aa; no Hp match; Updated (2006) note: One probable transmembrane helices predicted by TMHMM2.0. Similar to hypothetical proteins from other bacteria. Functional classification -Unknown.
       0.553
Cj1386
Original (2000) note: Cj1386, ankyrin-repeat containing protein, len: 412 aa; similar to proteins downstream of catalase in Pseudomonads e.g. TR:P95546 (EMBL:U16026) Pseudomonas syringae ANKF precursor (183 aa), fasta scores; opt: 217 z-score: 286.8 E(): 1.2e-08,31.3% identity in 134 aa overlap, and to eukaryotic ankyrin proteins e.g. ANK1_MOUSE ankyrin (1862 aa), fasta scores; opt: 181 z-score: 226.3 E(): 2.8e-05, 29.1% identity in 117 aa overlap. No Hp match. Also similar to Cj0834c (29.3% identity in 99 aa overlap). Contains 2x Pfam match to entry PF00023 ank, Ank repeat; Updated (2 [...]
  
 
 0.536
Cj1166c
Original (2000) note: Cj1166c, probable integral membrane protein, len: 258 aa; some similarity to hypothetical proteins e.g. YJJP_ECOLI (277 aa), fasta scores; opt: 292 z-score: 367.7 E(): 3.5e-13, 25.8% identity in 236 aa overlap. No Hp match. Contains one Cys pair; Updated (2006) note: Pfam domain PF06738 Protein of unknown function (DUF1212) identified within CDS. Five probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. Functional classification - Membranes, lipoproteins and porins.
  
    0.523
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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