STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cj1227cOriginal (2000) note: Cj1227c, probable two-component regulator, len: 224 aa; identical to TR:Q46095 (EMBL:U27271) C. jejuni CDS (called ompR) (198 aa), and similar to many e.g. YYCF_BACSU hypothetical 27.2 kd sensory transduction protein (235 aa), fasta scores; opt: 490 z-score: 561.1 E(): 5.9e-24, 36.4% identity in 225 aa overlap. No Hp ortholog. Contains Pfam match to entry PF00072 response_reg, Response regulator receiver domain, and Pfam match to entry PF00486 trans_reg_C,Transcriptional regulatory protein, C terminal. Also similar to Cj1261 (50.7% identity in 223 aa overlap); Upd [...] (224 aa)    
Predicted Functional Partners:
Cj1226c
Original (2000) note: Cj1226c, probable two-component sensor (histidine kinase), len: 415 aa; similar to many sensor proteins e.g. CPXA_ECOLI sensor protein CPXA (457 aa), fasta scores; opt: 205 z-score: 241.7 E(): 3.7e-06, 25.2% identity in 270 aa overlap. No Hp ortholog. Contains Pfam match to entry PF00512 signal,Signal carboxyl-terminal domain, and two possible membrane spanning domains. Also similar to Cj1262 (31.0% identity in 410 aa overlap); Updated (2006) note: Pfam domains PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase motifs,PF00512 His Kinase A (phosphoacce [...]
 
 0.988
Cj0247c
Hypothetical protein Cj0247c; Original (2000) note: Cj0247c, unknown, len: 177 aa; no Hp match; Updated (2006) note: Similar to proteins from other bacteria. Functional classification - Unknown.
  
 0.980
cheA
Chemotaxis histidine kinase; Original (2000) note: Cj0284c, cheA, probable chemotaxis histidine kinase, len: 769 aa; similar to many e.g. CHEA_ECOLI chemotaxis protein cheA (EC 2.7.3.-) (654 aa), fasta scores; opt: 1022 z-score: 1416.0 E(): 0, 35.7% identity in 658 aa overlap. 64.6% identity to HP0392. Contains Pfam matches to entry PF00072 response_reg,Response regulator receiver domain, score 103.80, E-value 3.4e-27 and to entry PF00512 signal, Signal carboxyl-terminal domain, score -12.30, E-value 0.00013; Updated (2006) note: Characterised within Escherichia coli with marginal iden [...]
  
0.959
Cj0889c
Original (2000) note: Cj0889c, probable sensory transduction histidine kinase, len: 429 aa; similar in C-terminus to many e.g. ENVZ_ECOLI osmolarity sensor protein ENVZ (450 aa), fasta scores; opt: 210 z-score: 229.3 E(): 1.8e-05. 26.5% identity in 204 aa overlap No Hp ortholog. Contains two probable transmembrane domains in N-terminus and Pfam match to entry PF00512 signal, Signal carboxyl-terminal domain; Updated (2006) note: Pfam domain PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase identified within CDS. Further support given to product function. Some characterisat [...]
  
  0.924
dccS
Original (2000) note: Cj1222c, probable two-component sensor (histidine kinase), len: 396 aa; similar to many sensor proteins e.g. RSTB_ECOLI sensor protein RSTB (433 aa), fasta scores; opt: 226 z-score: 267.7 E(): 1.3e-07, 24.5% identity in 237 aa overlap. 28.5% identity to HP1364. Contains Pfam match to entry PF00512 signal, Signal carboxyl-terminal domain, and two possible membrane spanning domains; Updated (2006) note: Pfam domains PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase motif and PF00512 His Kinase A (phosphoacceptor) domain were identified within CDS. Pros [...]
  
  0.922
Cj1492c
Putative two-component sensor; Original (2000) note: Cj1492c, probable two-component sensor, len: 403 aa; similar to many e.g. KINC_BACSU sporulation kinase C (428 aa), fasta scores; opt: 281 z-score: 301.1 E(): 1.9e-09, 29.3% identity in 242 aa overlap. No Hp ortholog. Contains Pfam match to entry PF00512 signal, Signal carboxyl-terminal domain; Updated (2006) note: No specific characterisation with acceptable identity score has been carried out yet,so putative kept within product function. Functional classification - Signal transduction.
  
  0.860
racS
Original (2000) note: Cj1262, racS, probable two-component sensor (histidine kinase), len: 411 aa; 99.5% identical to TR:O68796 (EMBL:AF053961) C. jejuni putative histidine protein kinase (fragment) (189 aa), and similar to e.g. ENVZ_ECOLI osmolarity sensor protein ENVZ (450 aa), fast scores; opt: 188 z-score: 217.1 E(): 8.5e-05, 24.4% identity in 242 aa overlap. N-term has 28.2% identity to HP0165, C-term has 37.9% identity to HP0164. Also similar to Cj1226c (31.3% identity in 412 aa overlap). Contains Pfam match to entry PF00512 signal,Signal carboxyl-terminal domain, and Pfam match [...]
 
 0.853
cheV
Chemotaxis protein; Original (2000) note: Cj0285c, cheV, probable chemotaxis protein cheV, len: 318 aa; similar to e.g. CHEV_BACSU chemotaxis cheV protein (EC 2.7.3.-) (303 aa),fasta scores; opt: 414 z-score: 344.9 E(): 5.9e-12, 28.2% identity in 309 aa overlap. 50.8% identity to HP0393. Contains Pfam match to entry PF00072 response_reg,Response regulator receiver domain, score 50.70, E-value 3.1e-11; Updated (2006) note: Pfam domain PF01584 CheW-like domain identified within CDS. Further support given to product function. Characterised within Bacillus subtilis with marginal identity s [...]
  
 0.832
htrA
Serine protease (protease DO); Original (2000) note: Cj1228c, htrA, probable serine protease (protease DO), len: 472 aa; 99.2% identical to TR:Q46120 (EMBL:X82628) C. jejuni serine protease htrA (472 aa), and similar to e.g. HTRA_ECOLI protease DO precursor (EC 3.4.21.-) (474 aa), fasta scores; opt: 965 z-score: 1004.5 E(): 0, 39.5% identity in 461 aa overlap. 50.5% identity to HP1019. Contains Pfam match to entry PF00089 trypsin, and 2x Pfam match to entry PF00595 PDZ, PDZ domain; Updated (2006) note: Characterised in Escherichia coli and Campylobacter jejuni, so putative not added to [...]
  
  
 0.826
Cj1110c
Original (2000) note: Cj1110c, probable MCP-type signal transduction protein, len: 429 aa; similar to TR:O68016 (EMBL:AF010180) Agrobacterium tumefaciens plasmid pTiC58 MCPA (579 aa), fasta scores; opt: 749 z-score: 785.2 E(): 0, 34.5% identity in 496 aa overlap,and to many other proteins with MCP domains e.g. PILJ_PSEAE PILJ protein (682 aa), fasta scores; opt: 379 z-score: 399.1 E(): 6.3e-15, 26.9% identity in 443 aa overlap, and HLYB_VIBCH hemolysin secretion protein precursor (548 aa), fasta scores; opt: 357 z-score: 377.6 E(): 9.8e-14, 37.0% identity in 173 aa overlap. No Hp ortho [...]
  
 0.822
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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