node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cj1049c | pdxA | Cj1049c | Cj1239 | Putative LysE family transporter protein; Original (2000) note: Cj1049c, probable integral membrane protein, len: 199 aa; similar to hypothetical membrane proteins belonging to the UPF0056 (MARC) family e.g. YVBG_BACSU (211 aa), fasta scores; opt: 173 z-score: 220.6 E(): 5.4e-05, 32.8% identity in 189 aa overlap. No Hp match; Updated (2006) note: Six probable transmembrane helices predicted by TMHMM2.0. Also, Pfam domain PF01810 LysE type translocator identified within CDS. Lysine exporter protein is involved in the efflux of excess L-lysine as a control for intracellular levels of L-l [...] | Putative 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). | 0.494 |
Cj1237c | pdxA | Cj1237c | Cj1239 | Putative phosphatase; Original (2000) note: Cj1237c, possible phosphatase, len: 324 aa; weak similarity to e.g. GPPA_ECOLI guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (494 aa), fasta scores; opt: 174 z-score: 201.9 E(): 0.0006, 25.7% identity in 323 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF02541 Ppx/GppA phosphatase family was identified within CDS. Further support given to product function. No specific characterisation with acceptable identity score carried out yet, so putative kept within product function (previously was posssible). Functional classifi [...] | Putative 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). | 0.620 |
Cj1237c | pdxJ | Cj1237c | Cj1238 | Putative phosphatase; Original (2000) note: Cj1237c, possible phosphatase, len: 324 aa; weak similarity to e.g. GPPA_ECOLI guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (494 aa), fasta scores; opt: 174 z-score: 201.9 E(): 0.0006, 25.7% identity in 323 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF02541 Ppx/GppA phosphatase family was identified within CDS. Further support given to product function. No specific characterisation with acceptable identity score carried out yet, so putative kept within product function (previously was posssible). Functional classifi [...] | Pyridoxal phosphate biosynthetic protein; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. | 0.610 |
dapA-2 | pabB | Cj0806 | Cj0862c | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | Original (2000) note: Cj0862c, pabB, probable para-aminobenzoate synthase component I, len: 594 aa; simlar to e.g. PABB_ECOLI para-aminobenzoate synthase component I (EC 4.1.3.-) (453 aa), fasta scores; opt: 541 z-score: 604.3 E(): 2.3e-26, 35.7% identity in 252 aa overlap. 39.3% identity to HP0293. Contains Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme; Updated (2006) note: Characterised in Escherichia coli with acceptable identity score. Putative not added to product function. Functional classification - Biosynthesis of cofactors, prosthetic groups and carrie [...] | 0.477 |
dapA-2 | pdxA | Cj0806 | Cj1239 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | Putative 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). | 0.436 |
ksgA | pabB | Cj1711c | Cj0862c | Putative dimethyladenosine transferase (16S rRNA dimethylase); Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | Original (2000) note: Cj0862c, pabB, probable para-aminobenzoate synthase component I, len: 594 aa; simlar to e.g. PABB_ECOLI para-aminobenzoate synthase component I (EC 4.1.3.-) (453 aa), fasta scores; opt: 541 z-score: 604.3 E(): 2.3e-26, 35.7% identity in 252 aa overlap. 39.3% identity to HP0293. Contains Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme; Updated (2006) note: Characterised in Escherichia coli with acceptable identity score. Putative not added to product function. Functional classification - Biosynthesis of cofactors, prosthetic groups and carrie [...] | 0.479 |
ksgA | pdxA | Cj1711c | Cj1239 | Putative dimethyladenosine transferase (16S rRNA dimethylase); Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | Putative 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). | 0.598 |
nadD | pdxA | Cj1404 | Cj1239 | Putative nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Putative 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). | 0.430 |
nadD | ribA | Cj1404 | Cj0572 | Putative nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the N-terminal section; belongs to the DHBP synthase family. | 0.448 |
pabB | dapA-2 | Cj0862c | Cj0806 | Original (2000) note: Cj0862c, pabB, probable para-aminobenzoate synthase component I, len: 594 aa; simlar to e.g. PABB_ECOLI para-aminobenzoate synthase component I (EC 4.1.3.-) (453 aa), fasta scores; opt: 541 z-score: 604.3 E(): 2.3e-26, 35.7% identity in 252 aa overlap. 39.3% identity to HP0293. Contains Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme; Updated (2006) note: Characterised in Escherichia coli with acceptable identity score. Putative not added to product function. Functional classification - Biosynthesis of cofactors, prosthetic groups and carrie [...] | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | 0.477 |
pabB | ksgA | Cj0862c | Cj1711c | Original (2000) note: Cj0862c, pabB, probable para-aminobenzoate synthase component I, len: 594 aa; simlar to e.g. PABB_ECOLI para-aminobenzoate synthase component I (EC 4.1.3.-) (453 aa), fasta scores; opt: 541 z-score: 604.3 E(): 2.3e-26, 35.7% identity in 252 aa overlap. 39.3% identity to HP0293. Contains Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme; Updated (2006) note: Characterised in Escherichia coli with acceptable identity score. Putative not added to product function. Functional classification - Biosynthesis of cofactors, prosthetic groups and carrie [...] | Putative dimethyladenosine transferase (16S rRNA dimethylase); Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | 0.479 |
pabB | pdxA | Cj0862c | Cj1239 | Original (2000) note: Cj0862c, pabB, probable para-aminobenzoate synthase component I, len: 594 aa; simlar to e.g. PABB_ECOLI para-aminobenzoate synthase component I (EC 4.1.3.-) (453 aa), fasta scores; opt: 541 z-score: 604.3 E(): 2.3e-26, 35.7% identity in 252 aa overlap. 39.3% identity to HP0293. Contains Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme; Updated (2006) note: Characterised in Escherichia coli with acceptable identity score. Putative not added to product function. Functional classification - Biosynthesis of cofactors, prosthetic groups and carrie [...] | Putative 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). | 0.416 |
pabB | ribA | Cj0862c | Cj0572 | Original (2000) note: Cj0862c, pabB, probable para-aminobenzoate synthase component I, len: 594 aa; simlar to e.g. PABB_ECOLI para-aminobenzoate synthase component I (EC 4.1.3.-) (453 aa), fasta scores; opt: 541 z-score: 604.3 E(): 2.3e-26, 35.7% identity in 252 aa overlap. 39.3% identity to HP0293. Contains Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme; Updated (2006) note: Characterised in Escherichia coli with acceptable identity score. Putative not added to product function. Functional classification - Biosynthesis of cofactors, prosthetic groups and carrie [...] | GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the N-terminal section; belongs to the DHBP synthase family. | 0.497 |
pabB | serC | Cj0862c | Cj0326 | Original (2000) note: Cj0862c, pabB, probable para-aminobenzoate synthase component I, len: 594 aa; simlar to e.g. PABB_ECOLI para-aminobenzoate synthase component I (EC 4.1.3.-) (453 aa), fasta scores; opt: 541 z-score: 604.3 E(): 2.3e-26, 35.7% identity in 252 aa overlap. 39.3% identity to HP0293. Contains Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme; Updated (2006) note: Characterised in Escherichia coli with acceptable identity score. Putative not added to product function. Functional classification - Biosynthesis of cofactors, prosthetic groups and carrie [...] | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.602 |
pdxA | Cj1049c | Cj1239 | Cj1049c | Putative 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). | Putative LysE family transporter protein; Original (2000) note: Cj1049c, probable integral membrane protein, len: 199 aa; similar to hypothetical membrane proteins belonging to the UPF0056 (MARC) family e.g. YVBG_BACSU (211 aa), fasta scores; opt: 173 z-score: 220.6 E(): 5.4e-05, 32.8% identity in 189 aa overlap. No Hp match; Updated (2006) note: Six probable transmembrane helices predicted by TMHMM2.0. Also, Pfam domain PF01810 LysE type translocator identified within CDS. Lysine exporter protein is involved in the efflux of excess L-lysine as a control for intracellular levels of L-l [...] | 0.494 |
pdxA | Cj1237c | Cj1239 | Cj1237c | Putative 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). | Putative phosphatase; Original (2000) note: Cj1237c, possible phosphatase, len: 324 aa; weak similarity to e.g. GPPA_ECOLI guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (494 aa), fasta scores; opt: 174 z-score: 201.9 E(): 0.0006, 25.7% identity in 323 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF02541 Ppx/GppA phosphatase family was identified within CDS. Further support given to product function. No specific characterisation with acceptable identity score carried out yet, so putative kept within product function (previously was posssible). Functional classifi [...] | 0.620 |
pdxA | dapA-2 | Cj1239 | Cj0806 | Putative 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | 0.436 |
pdxA | ksgA | Cj1239 | Cj1711c | Putative 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). | Putative dimethyladenosine transferase (16S rRNA dimethylase); Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | 0.598 |
pdxA | nadD | Cj1239 | Cj1404 | Putative 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). | Putative nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.430 |
pdxA | pabB | Cj1239 | Cj0862c | Putative 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). | Original (2000) note: Cj0862c, pabB, probable para-aminobenzoate synthase component I, len: 594 aa; simlar to e.g. PABB_ECOLI para-aminobenzoate synthase component I (EC 4.1.3.-) (453 aa), fasta scores; opt: 541 z-score: 604.3 E(): 2.3e-26, 35.7% identity in 252 aa overlap. 39.3% identity to HP0293. Contains Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme; Updated (2006) note: Characterised in Escherichia coli with acceptable identity score. Putative not added to product function. Functional classification - Biosynthesis of cofactors, prosthetic groups and carrie [...] | 0.416 |