STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
pseGNucleotidase specific for PseC product,UDP-4-amino-4,6-dideoxy-beta-L-AltNAc; Nucleotide sugar hydrolase that catalyzes the fourth step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Mediates the removal of UDP from C-1 of UDP- 2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose forming 2,4- diacetamido-2,4,6-trideoxy-beta-L-altropyranose. Belongs to the PseG family. (274 aa)    
Predicted Functional Partners:
pseH
N-acetyltransferase specific for PseC product,UDP-4-amino-4,6-dideoxy-beta-L-AltNAc; Catalyzes the third step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Mediates N-4 acetylation of UDP-4-amino-4,6-dideoxy-beta-L-AltNAc to form UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose (By similarity).
 
 
 0.994
pseI
Pse synthetase; Catalyzes the fifth step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Catalyzes the condensation of phosphoenolpyruvate with 2,4-diacetamido- 2,4,6-trideoxy-beta-l-altropyranose, forming pseudaminic acid.
 
 
 0.981
pseF
Putative acylneuraminate cytidylyltransferase; Catalyzes the final step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Mediates the activation of pseudaminic acid with CMP by forming CMP- pseudaminic acid (By similarity).
 
   
 0.947
pseB
UDP-GlcNAc-specific C4,6 dehydratase/C5 epimerase; Catalyzes the first step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Has both C6 dehydratase and C5 epimerase activities that result in the production of both UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-4- hexulose and UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-4-hexulose. Belongs to the polysaccharide synthase family.
 
   
 0.911
pseC
C4 aminotransferase specific for PseB product; Catalyzes the second step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Uses UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-4-hexulose as substrate producing UDP-4-amino-4,6-dideoxy-beta-L-AltNAc.
 
  
 0.824
neuB2
N-acetylneuraminic acid synthetase; Involved in biosynthesis of legionaminic acid (5,7-diamino- 3,5,7,9-tetradeoxy-D-glycero-D-galacto-non-2-ulosonic acid)(Leg), a sialic acid-like derivative that is incorporated into flagellin via O- linkage to Ser/Thr. Catalyzes the condensation of 2,4-diacetamido- 2,4,6-trideoxymannose with phosphoenolpyruvate (PEP) to give N,N'- diacetyllegionaminic acid.
 
 
 0.712
Cj1309c
Hypothetical protein Cj1309c; Original (2000) note: Cj1309c, unknown, len 356 aa; no Hp match; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Functional classification - Unknown; PMID:16573682, PMID:12781527.
 
     0.599
neuB1
Sialic acid synthase (N-acetylneuraminic acid synthetase); Original (2000) note: Cj1141, neuB1, probable N-acetylneuraminic acid synthetase, len: 343 aa; highly similar to e.g. TR:Q57265 (EMBL:U40740) N-acetylneuraminic acid synthetase (EC 4.1.3.-) (349 aa), fasta scores; opt: 1327 z-score: 1554.1 E(): 0, 59.0% identity in 344 aa overlap. No Hp ortholog. Also similar to Cj1327 (37.1% identity in 329 aa overlap) and Cj1317 (34.4% identity in 340 aa overlap); Updated (2006) note: Pfam domains PF03102 NeuB family and PF01354 Antifreeze-like domain were identified within CDS. Characterisat [...]
 
 
 0.566
Cj1310c
Hypothetical protein Cj1310c (617 family); Original (2000) note: Cj1310c, unknown, len: 404 aa; no Hp match. A member of the 617 family of C.j. proteins containing homopolymeric tracts; similar to Cj1305c (63.7% identity in 402 aa overlap), Cj1306c (59.8% identity in 410 aa overlap), Cj1342c (37.1% identity in 426 aa overlap) and Cj0617/Cj0618 (37.4% identity in 182 aa overlap/34.1% identity in 220 aa overlap). Contains a variable polyG-tract at aa 194; G(9) (consensus) gives this ORF, G(10) would cause truncation after 22 aa; Updated (2006) note: Similar to hypothetical proteins from [...]
  
    0.565
flaD
Putative flagellin; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
 
   
 0.528
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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