STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
neuC2Putative UDP-N-acetylglucosamine 2-epimerase; Involved in biosynthesis of legionaminic acid (5,7-diamino- 3,5,7,9-tetradeoxy-D-glycero-D-galacto-non-2-ulosonic acid)(Leg), a sialic acid-like derivative that is incorporated into flagellin via O- linkage to Ser/Thr. Catalyzes the conversion of GDP-N,N'- diacetylbacillosamine (Bac2Ac4Ac) into 2,4-diacetamido-2,4,6- trideoxymannose and GDP. It can also use UDP-N,N'-diacetylbacillosamine however it generates small quantities of 2,4-diacetamido-2,4,6- trideoxymannose. (384 aa)    
Predicted Functional Partners:
neuB2
N-acetylneuraminic acid synthetase; Involved in biosynthesis of legionaminic acid (5,7-diamino- 3,5,7,9-tetradeoxy-D-glycero-D-galacto-non-2-ulosonic acid)(Leg), a sialic acid-like derivative that is incorporated into flagellin via O- linkage to Ser/Thr. Catalyzes the condensation of 2,4-diacetamido- 2,4,6-trideoxymannose with phosphoenolpyruvate (PEP) to give N,N'- diacetyllegionaminic acid.
 
 
 0.997
Cj1329
Original (2000) note: Cj1329, probable sugar-phosphate nucleotide transferase, len: 341 aa; similar in C-term (120 aa - end) to many predicted transferases, and to MPG1_YEAST mannose-1-phosphate guanyltransferase (361 aa), fasta scores; opt: 304 z-score: 343.2 E(): 8.1e-12, 28.9% identity in 225 aa overlap. N-term has some similarity to CBS domains in nucleotide dehydrogenases e.g. IMDH_BACSU inosine-5'-monophosphate dehydrogenase (513 aa), blastp scores; E=0.00034, 30% identity in 116 overlap. N-term contains 2x Pfam match to entry PF00571 CBS, CBS domain,C-term contains Pfam match to [...]
 
 
 0.996
ptmB
Acylneuraminate cytidylyltransferase (flagellin modification); Involved in biosynthesis of legionaminic acid (5,7-diamino- 3,5,7,9-tetradeoxy-D-glycero-D-galacto-non-2-ulosonic acid)(Leg), a sialic acid-like derivative that is incorporated into flagellin via O- linkage to Ser/Thr. Catalyzes the conversion of N,N'- diacetyllegionaminic acid (Leg5Ac7Ac) and CTP into CMP-N,N'- diacetyllegionaminic acid (CMP-Leg5Ac7Ac). Belongs to the CMP-NeuNAc synthase family.
 
  
 0.994
Cj1319
Original (2000) note: Cj1319, probable nucleotide sugar dehydratase, len: 323 aa; similar to e.g. TR:Q54116 (EMBL:L37354) thymidine diphosphoglucose 4,6-dehydratase (329 aa), fasta scores; opt: 526 z-score: 600.3 E(): 3.9e-26, 29.5% identity in 315 aa overlap. No Hp ortholog. Contains Pfam match to entry PF00106 adh_short,Alcohol/other dehydrogenases, short chain type; Updated (2006) note: Pfam domain now altered to PF01370 NAD dependent epimerase/dehydratase family. Further support given to product function. No specific characterisation with acceptable identity score carried out yet. [...]
 
 
 0.990
Cj1330
Hypothetical protein Cj1330; Original (2000) note: Cj1330, unknown, len: 301 aa; some similarity to predicted oxidoreductases e.g. TR:O26961 (EMBL:AE000863) Methanobacterium thermoautotrophicum MTH875 (predicted 3-chlorobenzoate-3,4-dioxygenase dyhydrogenase related protein) (318 aa), fasta scores; opt: 199 z-score: 244.0 E(): 2.7e-06, 24.7% identity in 267 aa overlap, and TR:Q53739 (EMBL:X92429) Streptomyces alboniger predicted oxido-reductase (338 aa), fasta scores; opt: 135 z-score: 167.8 E(): 0.048, 27.0% identity in 196 aa overlap. No Hp match; Updated (2006) note: Identifed as pa [...]
 
 
 0.988
ptmA
Putative oxidoreductase (flagellin modification); Original (2000) note: Cj1332, ptmA, probable oxidoreductase, len: 256 aa; 79.3% identical to PTMA_CAMCO posttranslational flagellin modification protein A (256 aa), and similar to e.g. DHG2_BACME glucose 1-dehydrogenase II (261 aa), fasta scores; opt: 236 z-score: 281.8 E(): 2.1e-08, 24.1% identity in 261 aa overlap. No Hp ortholog. Contains fam match to entry PF00106 adh_short, Alcohol/other dehydrogenases, short chain type, and Pfam match to entry PF00678 adh_short_C2,Short chain dehydrogenase/reductase C-terminus; Updated (2006) note [...]
 
  
 0.985
maf3
Motility accessory factor (function unknown); Original (2000) note: Cj1334, unknown, len: 619 aa; no Hp ortholog, but 34.8% identity to HP0114. A member of the 1318 family of proteins. Similar to Cj1333 (41.9% identity in 645 aa overlap), Cj1318 (41.0% identity in 647 aa overlap), Cj1336 (41.9% identity in 590 aa overlap),Cj1337 (43.8% identity in 628 aa overlap), Cj1341c (34.3% identity in 621 aa overlap), and Cj1340c (34.0% identity in 618 aa overlap); Updated (2006) note: Pfam domain PF01973 Protein of unknown function DUF115 identified within CDS. Some characterisation work has bee [...]
  
  
 0.977
pseE
PseE protein; Original (2000) note: Cj1337, unknown, len: 628 aa; 35.0% identity to HP0114. A member of the 1318 family of proteins. Simlar to Cj1333 (48.6% identity in 636 aa overlap), Cj1318 (48.1% identity in 643 aa overlap),Cj1336 (48.6% identity in 586 aa overlap), Cj1334 (43.6% identity in 628 aa overlap), Cj1340c (32.2% identity in 624 aa overlap), Cj1341c (31.9% identity in 627 aa overlap); Updated (2006) note: Pfam domain PF01973 Protein of unknown function DUF115 identified within CDS. Some characterisation work carried out within Campylobacter jejuni. Product function modifi [...]
  
    0.967
Cj1320
Putative aminotransferase (degT family); Original (2000) note: Cj1320, probable aminotransferase, len: 384 aa; similar to members of the degT family e.g. TR:Q06953 (EMBL:X59554) Vibrio cholerae RFBE protein (367 aa), fasta scores; opt: 315 z-score: 377.4 E(): 1e-13, 32.7% identity in 361 aa overlap. No Hp ortholog. Contains Pfam match to entry PF01041 DegT_DnrJ_EryC1, DegT/DnrJ/EryC1/StrS family; Updated (2006) note: No specific characterisation with acceptable identity score has been carried out yet. Putative kept within product function. Identifed as part of Campylobacter jejuni O-li [...]
 
  
 0.964
pseD
PseD protein; Original (2000) note: Cj1333, unknown, len: 653 aa; no Hp ortholog, but 34.6% identity to HP0114. A member of the 1318 family of proteins. Similar to Cj1318 (72.5% identity in 658 aa overlap), Cj1337 (48.6% identity in 636 aa overlap), Cj1334 (41.8% identity in 644 aa overlap),Cj1340c (30.4% identity in 615 aa overlap), Cj1341c (31.2% identity in 616 aa overlap) and Cj1335/Cj1336 (94.2% identity in 52 aa overlap/71.7% identity in 597 aa overlap); Updated (2006) note: Pfam domain PF01973 Protein of unknown function DUF115 identified within CDS. Characterised work has been [...]
  
    0.955
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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