STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
flaAFlagellin; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. FlaA binds to flagellar assembly factor FliW protein, preventing FliW from binding to CsrA, so that CsrA can then bind flaA mRNA and represses its translation. (572 aa)    
Predicted Functional Partners:
fliS
Flagellar protein; Original (2000) note: Cj0549, fliS, probable flagellar protein, len: 128 aa; similar to e.g. FLIS_SALTY flagellar protein FLIS (135 aa), fasta scores; opt: 190 z-score: 343.0 E(): 8.2e-12, 34.2% identity in 117 aa overlap. 60.5% identity to HP0753; Updated (2006) note: Pfam domain PF02561 Flagellar protein FliS was identified within CDS. Further support given to product function. Characterised within Bacillus subtilis and others with marginal identity scores. Putative not added to product function. Functional classification - Surface structures; PMID:8195064, PMID:15 [...]
 
 
 0.997
flgK
Original (2000) note: Cj1466, flgK, possible flagellar hook-associated protein, len: 608 aa; some similarity to e.g. FLGK_ECOLI flagellar hook-associated protein 1 (546 aa), fasta scores; opt: 261 z-score: 274.8 E(): 5.5e-08, 22.9% identity in 612 aa overlap. 36.4% identity to HP1119. Contains Pfam match to entry PF00460 flg_bb_rod, Flagella basal body rod proteins; Updated (2006) note: Characterisation has been carried out within Salmonella spp. however, identity scores were unnacceptable, so putative kept within product function. Functional classification - Surface structures; PMID:1 [...]
 
  
 0.972
fliD
Flagellar hook-associated protein; Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end (By similarity).
 
 
 0.971
flaB
Flagellin; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
 
  
0.957
flgE
Flagellar hook protein; Original (2000) note: Cj0043, flgE, probable flagellar hook protein, len: 545 aa; similar to e.g. FLGE_BORBU flagellar hook protein flgE (442 aa), fasta scores; opt: 350 z-score: 665.8 E(): 7.9e-30, 27.5% identity in 553 aa overlap. 24.5% identity to HP0908. Contains PS00588 Flagella basal body rod proteins signature and Pfam match to entry PF00460 flg_bb_rod,Flagella basal body rod proteins, score 37.00, E-value 6.7e-08; Updated (2006) note: Characterised within Borrilia burgdorferi and also some work within Campylobacter jejuni. Identity scores were marginal. [...]
 
  
 0.941
fliW
Conserved hypothetical protein Cj1075; Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum (Probable). Antagonizes CsrA-mediated translational repression of flaA in a promoter-independent manner, leading to expression of FlaA and probably other flagellar genes. Binds to FlaA, which releases CsrA to repress translation of flaA mRNA. Also has a negative effect on flaA transcription, and influences the localization of flaA mRNA to the poles [...]
  
 
 0.939
flgE2
Flagellar hook subunit protein; Original (2000) note: Cj1729c, flgE2, probable flagellar hook subunit protein, len: 865 aa; highly similar to e.g. TR:O86144 (EMBL:AJ002074) C. jejuni flagellar hook subunit protein (862 aa), fasta scores; opt: 4848 z-score: 4883.1 E(): 0, 86.4% identity in 869 aa overlap. 35.5% identity to HP0870. Also similar to Cj0043 flgE (25.4% identity in 488 aa overlap). Contains Pfam match to entry PF00460 flg_bb_rod, Flagella basal body rod proteins, and PS00017 ATP/GTP-binding site motif A (P-loop); Updated (2006) note: Characterised in Campylobacter jejuni. Ap [...]
  
 
 0.939
fliG
Original (2000) note: Cj0319, fliG, probable flagellar motor switch protein, len: 342 aa; similar to many e.g. FLIG_ECOLI flagellar motor switch protein fliG (331 aa), fasta scores; opt: 609 z-score: 927.6 E(): 0,30.1% identity in 326 aa overlap. 61.5% identity to HP0352; Updated (2006) note: Pfam domain PF01706 FliG C-terminal domain was identified. Further supoport given to product function. Characterised within Escherichia coli with marginal identity score. Putative not added to product function. Functional classification - Surface structures; PMID:1551848, PMID:8308888, PMID:8550421.
 
  
 0.938
flgB
Flagellar basal-body rod protein; Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
 
 
 0.929
fliM
Flagellar motor switch protein; Original (2000) note: Cj0060c, fliM, probable flagellar motor switch protein, len: 359 aa; simlar to e.g. FLIM_BACSU flagellar motor switch protein fliM (332 aa), fasta scores; opt: 728 z-score: 1046.5 E(): 0, 35.6% identity in 329 aa overlap. 61.1% identity to HP1031; Updated (2006) note: Pfam domain PF01052 Surface presentation of antigens (SPOA) protein and PF02154 Flagellar motor switch protein FliM were identified within CDS. Further support given to product function. Characterised within Bacillus subtilis with acceptable identity score. Thus, putat [...]
 
  
 0.928
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.