node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cj0645 | Cj1374c | Cj0645 | Cj1374c | Original (2000) note: Cj0645, possible secreted transglycosylase, len: 372 aa; similar to members of the SLT family e.g. MLTD_ECOLI membrane-bound lytic murein transglycosylase D precursor (EC 3.2.1.-) (452 aa), fasta scores; opt: 425 z-score: 431.3 E(): 1e-16, 28.4% identity in 348 aa overlap. 37.5% identity to HP1572. Contains N-terminal signal sequence; Updated (2006) note: Pfam domains PF01464 Transglycosylase SLT domain PF01476 LysM domain were identified within CDS. Further support given to product function. Characterised within Escherichia coli with marginal identity score and o [...] | Conserved hypothetical protein Cj1374c; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. | 0.672 |
Cj0645 | guaA | Cj0645 | Cj1248 | Original (2000) note: Cj0645, possible secreted transglycosylase, len: 372 aa; similar to members of the SLT family e.g. MLTD_ECOLI membrane-bound lytic murein transglycosylase D precursor (EC 3.2.1.-) (452 aa), fasta scores; opt: 425 z-score: 431.3 E(): 1e-16, 28.4% identity in 348 aa overlap. 37.5% identity to HP1572. Contains N-terminal signal sequence; Updated (2006) note: Pfam domains PF01464 Transglycosylase SLT domain PF01476 LysM domain were identified within CDS. Further support given to product function. Characterised within Escherichia coli with marginal identity score and o [...] | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.824 |
Cj0645 | guaB | Cj0645 | Cj1058c | Original (2000) note: Cj0645, possible secreted transglycosylase, len: 372 aa; similar to members of the SLT family e.g. MLTD_ECOLI membrane-bound lytic murein transglycosylase D precursor (EC 3.2.1.-) (452 aa), fasta scores; opt: 425 z-score: 431.3 E(): 1e-16, 28.4% identity in 348 aa overlap. 37.5% identity to HP1572. Contains N-terminal signal sequence; Updated (2006) note: Pfam domains PF01464 Transglycosylase SLT domain PF01476 LysM domain were identified within CDS. Further support given to product function. Characterised within Escherichia coli with marginal identity score and o [...] | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.796 |
Cj0645 | purA | Cj0645 | Cj1498c | Original (2000) note: Cj0645, possible secreted transglycosylase, len: 372 aa; similar to members of the SLT family e.g. MLTD_ECOLI membrane-bound lytic murein transglycosylase D precursor (EC 3.2.1.-) (452 aa), fasta scores; opt: 425 z-score: 431.3 E(): 1e-16, 28.4% identity in 348 aa overlap. 37.5% identity to HP1572. Contains N-terminal signal sequence; Updated (2006) note: Pfam domains PF01464 Transglycosylase SLT domain PF01476 LysM domain were identified within CDS. Further support given to product function. Characterised within Escherichia coli with marginal identity score and o [...] | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.554 |
Cj1374c | Cj0645 | Cj1374c | Cj0645 | Conserved hypothetical protein Cj1374c; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. | Original (2000) note: Cj0645, possible secreted transglycosylase, len: 372 aa; similar to members of the SLT family e.g. MLTD_ECOLI membrane-bound lytic murein transglycosylase D precursor (EC 3.2.1.-) (452 aa), fasta scores; opt: 425 z-score: 431.3 E(): 1e-16, 28.4% identity in 348 aa overlap. 37.5% identity to HP1572. Contains N-terminal signal sequence; Updated (2006) note: Pfam domains PF01464 Transglycosylase SLT domain PF01476 LysM domain were identified within CDS. Further support given to product function. Characterised within Escherichia coli with marginal identity score and o [...] | 0.672 |
Cj1374c | folE | Cj1374c | Cj0194 | Conserved hypothetical protein Cj1374c; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. | Original (2000) note: Cj0194, folE, GTP cyclohydrolase I, len: 190 aa; identical to, but slightly longer than, GCH1_CAMJE (179 aa), and highly similar to many e.g. GCH1_SYNY3 GTP cyclohydrolase I (EC 3.5.4.16) (234 aa), fasta scores; opt: 760 z-score: 1327.9 E(): 0,60.8% identity in 181 aa overlap. 49.7% identity to HP0928. Contains PS00859 GTP cyclohydrolase I signature 1 and Pfam match to entry PF01227 GTP_cyclohydro_I, GTP cyclohydrolase I, score 377.10, E-value 1.8e-109; Updated (2006) note: Characterised within Campylobacter jejuni and many others. Putative not added. Functional c [...] | 0.784 |
Cj1374c | folK | Cj1374c | Cj0065c | Conserved hypothetical protein Cj1374c; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. | Original (2000) note: Cj0065c, folK, possible 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, len: 157 aa, similar to e.g. HPPK_BACSU 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) (167 aa), fasta scores; opt: 194 z-score: 370.0 E(): 2.4e-13, 28.7% identity in 129 aa overlap. 35.6% identity to HP1036. Contains Pfam match to entry PF01288 HPPK,7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK), score 4.10, E-value 1.1e-06; Updated (2006) note: Characterised within Bacillus subtilis and Escherichia coli, however, identity sco [...] | 0.598 |
Cj1374c | guaA | Cj1374c | Cj1248 | Conserved hypothetical protein Cj1374c; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.915 |
Cj1374c | guaB | Cj1374c | Cj1058c | Conserved hypothetical protein Cj1374c; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.891 |
Cj1374c | murI | Cj1374c | Cj1652c | Conserved hypothetical protein Cj1374c; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.914 |
Cj1374c | nusG | Cj1374c | Cj0473 | Conserved hypothetical protein Cj1374c; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. | Transcription antitermination protein; Participates in transcription elongation, termination and antitermination. | 0.637 |
Cj1374c | purA | Cj1374c | Cj1498c | Conserved hypothetical protein Cj1374c; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.778 |
Cj1374c | pyk | Cj1374c | Cj0392c | Conserved hypothetical protein Cj1374c; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. | Pyruvate kinase; Original (2000) note: Cj0392c, pyk, probable pyruvate kinase, len: 480 aa; similar to e.g. KPYK_BACSU pyruvate kinase (EC 2.7.1.40) (585 aa), fasta scores; opt: 1111 z-score: 1494.8 E(): 0, 41.8% identity in 476 aa overlap. No Hp match. Contains PS00659 Glycosyl hydrolases family 5 signature and Pfam match to entry PF00224 PK,Pyruvate kinase, score 523.20, E-value 1.8e-153; Updated (2006) note: Pfam domain PF02887 Pyruvate kinase, alpha/beta domain protein was identified within CDS. Further support given to product function. Characterised within Bacillus subtilis with [...] | 0.668 |
Cj1374c | trpD | Cj1374c | Cj0346 | Conserved hypothetical protein Cj1374c; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. | Anthranilate synthase component II; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.614 |
folE | Cj1374c | Cj0194 | Cj1374c | Original (2000) note: Cj0194, folE, GTP cyclohydrolase I, len: 190 aa; identical to, but slightly longer than, GCH1_CAMJE (179 aa), and highly similar to many e.g. GCH1_SYNY3 GTP cyclohydrolase I (EC 3.5.4.16) (234 aa), fasta scores; opt: 760 z-score: 1327.9 E(): 0,60.8% identity in 181 aa overlap. 49.7% identity to HP0928. Contains PS00859 GTP cyclohydrolase I signature 1 and Pfam match to entry PF01227 GTP_cyclohydro_I, GTP cyclohydrolase I, score 377.10, E-value 1.8e-109; Updated (2006) note: Characterised within Campylobacter jejuni and many others. Putative not added. Functional c [...] | Conserved hypothetical protein Cj1374c; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. | 0.784 |
folE | folK | Cj0194 | Cj0065c | Original (2000) note: Cj0194, folE, GTP cyclohydrolase I, len: 190 aa; identical to, but slightly longer than, GCH1_CAMJE (179 aa), and highly similar to many e.g. GCH1_SYNY3 GTP cyclohydrolase I (EC 3.5.4.16) (234 aa), fasta scores; opt: 760 z-score: 1327.9 E(): 0,60.8% identity in 181 aa overlap. 49.7% identity to HP0928. Contains PS00859 GTP cyclohydrolase I signature 1 and Pfam match to entry PF01227 GTP_cyclohydro_I, GTP cyclohydrolase I, score 377.10, E-value 1.8e-109; Updated (2006) note: Characterised within Campylobacter jejuni and many others. Putative not added. Functional c [...] | Original (2000) note: Cj0065c, folK, possible 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, len: 157 aa, similar to e.g. HPPK_BACSU 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) (167 aa), fasta scores; opt: 194 z-score: 370.0 E(): 2.4e-13, 28.7% identity in 129 aa overlap. 35.6% identity to HP1036. Contains Pfam match to entry PF01288 HPPK,7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK), score 4.10, E-value 1.1e-06; Updated (2006) note: Characterised within Bacillus subtilis and Escherichia coli, however, identity sco [...] | 0.970 |
folE | guaB | Cj0194 | Cj1058c | Original (2000) note: Cj0194, folE, GTP cyclohydrolase I, len: 190 aa; identical to, but slightly longer than, GCH1_CAMJE (179 aa), and highly similar to many e.g. GCH1_SYNY3 GTP cyclohydrolase I (EC 3.5.4.16) (234 aa), fasta scores; opt: 760 z-score: 1327.9 E(): 0,60.8% identity in 181 aa overlap. 49.7% identity to HP0928. Contains PS00859 GTP cyclohydrolase I signature 1 and Pfam match to entry PF01227 GTP_cyclohydro_I, GTP cyclohydrolase I, score 377.10, E-value 1.8e-109; Updated (2006) note: Characterised within Campylobacter jejuni and many others. Putative not added. Functional c [...] | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.415 |
folE | pyk | Cj0194 | Cj0392c | Original (2000) note: Cj0194, folE, GTP cyclohydrolase I, len: 190 aa; identical to, but slightly longer than, GCH1_CAMJE (179 aa), and highly similar to many e.g. GCH1_SYNY3 GTP cyclohydrolase I (EC 3.5.4.16) (234 aa), fasta scores; opt: 760 z-score: 1327.9 E(): 0,60.8% identity in 181 aa overlap. 49.7% identity to HP0928. Contains PS00859 GTP cyclohydrolase I signature 1 and Pfam match to entry PF01227 GTP_cyclohydro_I, GTP cyclohydrolase I, score 377.10, E-value 1.8e-109; Updated (2006) note: Characterised within Campylobacter jejuni and many others. Putative not added. Functional c [...] | Pyruvate kinase; Original (2000) note: Cj0392c, pyk, probable pyruvate kinase, len: 480 aa; similar to e.g. KPYK_BACSU pyruvate kinase (EC 2.7.1.40) (585 aa), fasta scores; opt: 1111 z-score: 1494.8 E(): 0, 41.8% identity in 476 aa overlap. No Hp match. Contains PS00659 Glycosyl hydrolases family 5 signature and Pfam match to entry PF00224 PK,Pyruvate kinase, score 523.20, E-value 1.8e-153; Updated (2006) note: Pfam domain PF02887 Pyruvate kinase, alpha/beta domain protein was identified within CDS. Further support given to product function. Characterised within Bacillus subtilis with [...] | 0.481 |
folE | trpD | Cj0194 | Cj0346 | Original (2000) note: Cj0194, folE, GTP cyclohydrolase I, len: 190 aa; identical to, but slightly longer than, GCH1_CAMJE (179 aa), and highly similar to many e.g. GCH1_SYNY3 GTP cyclohydrolase I (EC 3.5.4.16) (234 aa), fasta scores; opt: 760 z-score: 1327.9 E(): 0,60.8% identity in 181 aa overlap. 49.7% identity to HP0928. Contains PS00859 GTP cyclohydrolase I signature 1 and Pfam match to entry PF01227 GTP_cyclohydro_I, GTP cyclohydrolase I, score 377.10, E-value 1.8e-109; Updated (2006) note: Characterised within Campylobacter jejuni and many others. Putative not added. Functional c [...] | Anthranilate synthase component II; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.498 |
folK | Cj1374c | Cj0065c | Cj1374c | Original (2000) note: Cj0065c, folK, possible 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, len: 157 aa, similar to e.g. HPPK_BACSU 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) (167 aa), fasta scores; opt: 194 z-score: 370.0 E(): 2.4e-13, 28.7% identity in 129 aa overlap. 35.6% identity to HP1036. Contains Pfam match to entry PF01288 HPPK,7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK), score 4.10, E-value 1.1e-06; Updated (2006) note: Characterised within Bacillus subtilis and Escherichia coli, however, identity sco [...] | Conserved hypothetical protein Cj1374c; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. | 0.598 |