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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
Cj1417cPutative amidotransferase; Involved in the biosynthesis of the O-methyl phosphoramidate (MeOPN) group found on the capsular polysaccharide (CPS) of C.jejuni. Catalyzes the hydrolysis of CDP-L-glutamine to L- glutamate and cytidine diphosphoramidate. (200 aa)    
Predicted Functional Partners:
Cj1418c
Putative transferase; Involved in the biosynthesis of the O-methyl phosphoramidate (MeOPN) group found on the capsular polysaccharide (CPS) of C.jejuni. Catalyzes the ATP-dependent phosphorylation of the amide nitrogen of L-glutamine to form L-glutamine phosphate, the first committed step in MeOPN biosynthesis. Does not phosphorylate L-glutamate or L-asparagine.
 
  
 0.978
Cj1419c
Putative methyltransferase; Original (2000) note: Cj1419c, possible methyltransferase, len: 253 aa; similar to hypothetical proteins e.g. TR:O53392 (EMBL:AL021841) Mycobacterium tuberculosis Rv3342 (MTV016.42) (243 aa), fasta scores; opt: 210 z-score: 250.1 E(): 1.3e-06, 32.0% identity in 122 aa overlap. Also contains weak similarity in part to several methyltransferases e.g. UBIE_ECOLI ubiquinone/menaquinone biosynthesis methyltransferase (251 aa), fasta scores; opt: 141 z-score: 171.3 E(): 0.032,24.2% identity in 132 aa overlap. No Hp match. Also similar to Cj1420c (33.7% identity in [...]
 
  
 0.946
Cj1416c
Putative sugar nucleotidyltransferase; Involved in the biosynthesis of the O-methyl phosphoramidate (MeOPN) group found on the capsular polysaccharide (CPS) of C.jejuni. Catalyzes the formation of CDP-L-glutamine from CTP and L-glutamine phosphate.
 
  
 0.935
cysC
Putative adenylylsulfate kinase; Involved in the biosynthesis of the O-methyl phosphoramidate (MeOPN) group found on the capsular polysaccharide (CPS) of C.jejuni. Catalyzes the ATP-dependent phosphorylation of cytidine diphosphoramidate (CDP-NH(2)) to form cytidine 3'-phosphate 5'-diphosphoramidate. Can also use other substrates such as the corresponding adenine and uridine diphosphoramidate derivatives or cytidine diphosphoramidate analogs, with lower efficiency.
 
  
 0.934
Cj1420c
Putative methyltransferase; Original (2000) note: Cj1420c, unknown, len: 258 aa; similar to hypothetical proteins e.g. TR:O53392 (EMBL:AL021841) Mycobacterium tuberculosis Rv3342 (MTV016.42) (243 aa), fasta scores; opt: 219 z-score: 263.3 E(): 2.4e-07, 30.7% identity in 137 aa overlap. Also similar to Cj1419c (34.1% identity in 255 aa overlap). Contains C(9-10) polymorphic region at aa 132. C9 (consensus) gives this ORF, C10 would give truncation after a further 19 aa; Updated (2006) note: Prostie domain PS00213 LIPOCALIN, Lipocalin signature identified within CDS. Conserved added to p [...]
 
  
 0.874
kpsC
Original (2000) note: Cj1414c, possible polysaccharide modification protein, len: 689 aa; similar to e.g. LIPA_NEIME capsule polysaccharide modification protein (400 aa), fasta scores; opt: 927 z-score: 1062.5 E(): 0, 39.6% identity in 394 aa overlap, and KSC5_ECOLI capsule polysaccharide export protein KPSC (675 aa), fasta scores; opt: 724 z-score: 827.0 E(): 0, 38.5% identity in 655 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF05159 Capsule polysaccharide biosynthesis protein identified within CDS. Further support given to product function. Possible removed from produc [...]
     
 0.839
kpsS
Original (2000) note: Cj1413c, possible polysaccharide modification protein, len: 394 aa; similar to e.g. LIPB_NEIME capsule polysaccharide modification protein (419 aa), fasta scores; opt: 744 z-score: 897.9 E(): 0, 38.5% identity in 395 aa overlap, and KSS5_ECOLI capsule polysaccharide export protein KPSS (389 aa), fasta scores; opt: 919 z-score: 1108.7 E(): 0, 40.2% identity in 383 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF05159 Capsule polysaccharide biosynthesis protein identified within CDS. Further support given to product function. Possible removed from produc [...]
  
    0.799
glnA
Glutamine synthetase; Original (2000) note: Cj0699c, glnA, probable glutamine synthetase, len: 476 aa; highly similar to many e.g. GLNA_ECOLI glutamine synthetase (EC 6.3.1.2) (468 aa), fasta scores; opt: 1529 z-score: 1812.8 E(): 0,51.5% identity in 462 aa overlap. 63.6% identity to HP0512. Contains PS00180 Glutamine synthetase signature 1,PS00181 Glutamine synthetase putative ATP-binding region signature, and Pfam match to entry PF00120 gln-synt; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. Putative not added to product function. Function [...]
  
 
 0.797
gltB
Original (2000) note: Cj0007, gltB, probable glutamate synthase (NADPH) large subunit, len: 1496 aa; similar to many e.g. GLTB_ECOLI glutamate synthase (NADPH) large chain (1517 aa), fasta scores; opt: 3846 z-score: 3828.3 E(): 0, 42.5% identity in 1488 aa overlap. No Hp match; Updated (2006) note: Pfam domains PF00310 Glutamine amidotransferases class-II, PF04898 Glutamate synthase central domain, PF01645 Conserved region in glutamate synthase and PF01493 GXGXG motif were all identified within CDS. Further support given to product function. Characterised within Bacillus subtilis with [...]
    
  0.794
putA
Putative proline dehydrogenase/delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family.
  
 
 0.746
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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