STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (249 aa)    
Predicted Functional Partners:
gltB
Original (2000) note: Cj0007, gltB, probable glutamate synthase (NADPH) large subunit, len: 1496 aa; similar to many e.g. GLTB_ECOLI glutamate synthase (NADPH) large chain (1517 aa), fasta scores; opt: 3846 z-score: 3828.3 E(): 0, 42.5% identity in 1488 aa overlap. No Hp match; Updated (2006) note: Pfam domains PF00310 Glutamine amidotransferases class-II, PF04898 Glutamate synthase central domain, PF01645 Conserved region in glutamate synthase and PF01493 GXGXG motif were all identified within CDS. Further support given to product function. Characterised within Bacillus subtilis with [...]
  
 
 0.928
lysA
Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine.
 
 0.898
nudH
Putative NUDIX hydrolase family protein; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily.
   
 
 0.888
murE
UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily.
 
 
 0.848
dapE
Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily.
  
 
 0.840
carB
Original (2000) note: Cj0279, carB, probable carbamoyl-phosphate synthase large chain, len: 1089 aa; highly similar to many e.g. CARB_ECOLI carbamoyl-phosphate synthase large chain (EC 6.3.5.5) (1072 aa), fasta scores; opt: 3268 z-score: 4517.4 E(): 0, 55.3% identity in 1098 aa overlap. 62.5% identity to HP0919. Contains 2x PS00866 Carbamoyl-phosphate synthase subdomain signature 1, 2x PS00867 Carbamoyl-phosphate synthase subdomain signature 2, and 2x Pfam match to entry PF00289 CPSase_L_chain,Carbamoyl-phosphate synthase (CPSase). Also contains apparent N-terminal signal sequence with [...]
 
 
  0.812
Cj1532
Putative periplasmic protein; Original (2000) note: Cj1532, possible periplasmic protein, len: 243 aa; some similarity to N-terminus of BAX_ECOLI BAX protein (274 aa), fasta scores; opt: 240 z-score: 286.1 E(): 1.3e-08, 38.3% identity in 120 aa overlap. No Hp match. Contains possible N-terminal signal sequence; Updated (2006) note: Pfam domain PF01832 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase (Glucosaminidase) identified within CDS. No specific characterisation carried out yet, so putative kept within product function. Functional classification -Miscellaneous periplasmic [...]
  
    0.801
murF
UDP-N-acetylmuramoyl-tripeptide D-alanyl-D-alanine ligase; Original (2000) note: Cj0795c, murF, possible UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate -- ligase, len: 475 aa; some similarity to e.g. MURF_BACSU UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate -- ligase (EC 6.3.2.15) (457 aa), fasta scores; opt: 235 z-score: 258.7 E(): 4.1e-07, 26.7% identity in 348 aa overlap. 41.5% identity to HP0740; Updated (2006) note: Pfam domains PF01225 Mur ligase family, catalytic domain and PF02875 Mur ligase family, glutamate ligase domain were identified within CDS. Also, [...]
    
 0.799
coaE
Putative dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.
       0.799
asd
Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family.
  
  
 0.791
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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