STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tupBPutative anion-uptake ABC-transport system permease protein; Part of an ABC transporter complex involved in ultra-high affinity tungstate uptake. Probably responsible for the translocation of the substrate across the membrane. (239 aa)    
Predicted Functional Partners:
tupC
Putative anion-uptake ABC-transport system ATP-binding protein; Part of an ABC transporter complex involved in ultra-high affinity tungstate uptake. Probably responsible for energy coupling to the transport system.
 
 
  0.991
tupA
Putative periplasmic protein; Part of an ABC transporter complex involved in ultra-high affinity tungstate uptake. Specifically binds tungstate.
 
 
 0.966
modA
Original (2000) note: Cj0303c, modA, probable molybdate-binding lipoprotein, len: 249 aa; similar to e.g. MODA_RHOCA molybdate-binding periplasmic protein precursor (252 aa), fasta scores; opt: 354 z-score: 449.0 E(): 9.4e-18, 30.8% identity in 224 aa overlap, and MODA_ECOLI (257 aa), fasta scores; opt: 220 z-score: 245.4 E(): 2.1e-06, 25.0% identity in 232 aa overlap. 42.3% identity to HP0473. Contains probable N-terminal signal sequence with appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; Updated (2006) note: Pfam domain PF01547 Bacterial extr [...]
 
  
 0.779
fdhA
Original (2000) note: Cj1511c, fdhA, probable formate dehydrogenase large subunit, len: 934 aa; similar to e.g. TR:P28179 (EMBL:X54057) Wolinella succinogenes formate dehydrogenase large subunit precursor (EC 1.2.1.2)(939 aa), fasta scores; opt: 3368 z-score: 3913.9 E(): 7.3e-211, 52.8% identity in 930 aa overlap, and FDHF_ECOLI formate dehydrogenase H (EC 1.2.1.2) (formate-hydrogen-lyase-linked, selenocysteine-containing polypeptide) (715 aa), fasta scores; opt: 813 z-score: 943.1 E(): 2.2e-45, 30.9% identity in 696 aa overlap. No Hp match. Contains Pfam match to entry PF00384 molybdo [...]
  
     0.619
pstB
Phosphate transport ATP-binding protein; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
   
 0.576
Cj0302c
Putative molybdenum-pterin binding protein; Original (2000) note: Cj0302c, unknonw, len: 133 aa; no Hp match; Updated (2006) note: Pfam domain PF03459 TOBE domain identified within CDS. TOBE (Transport-associated OB) has had work carried out within Esherichia coli where it has been shown to be involved in the recognition of small ligands such as molybdenum. TOBE has been found in ABC transporters immediately after the ATPase domain. A child process of this family is Molybdenum-pterin binding protein. Product modified to more specific family member based on motif match. Some characteris [...]
    
 0.547
metN
ABC transport system ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.
    
  0.523
modC
Original (2000) note: Cj0300c, modC, probable molybdenum transport ATP-binding protein, len: 294 aa; similar to many ABC-transporter ATP binding proteins, and to MODC_ECOLI molybdenum transport ATP-binding protein (352 aa), fasta scores; opt: 487 z-score: 700.9 E(): 8.7e-32, 34.8% identity in 270 aa overlap. Identification as modC is based on presence of probable molybdenum-specific permease and periplasmic binding proteins upstream. 46.8% identity to HP0475. Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00211 ABC transporters family signature and Pfam match to entry PF0000 [...]
    
  0.517
fdhB
Original (2000) note: Cj1510c, fdhB, probable formate dehydrogenase iron-sulfur subunit, len: 213 aa; similar to e.g. FDHB_WOLSU formate dehydrogenase iron-sulfur subunit (EC 1.2.1.2) (200 aa), fasta scores; opt: 1025 z-score: 1153.1 E(): 0, 69.5% identity in 197 aa overlap. No Hp ortholog. Contains PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature, and Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains; Updated (2006) note: Some characterisation in Wolinella succinogenes with acceptable identity score. Putative kept with [...]
  
     0.514
acs
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
  
    0.501
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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