STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hisBOriginal (2000) note: Cj1599, hisB, probable imidazoleglycerol-phosphate dehydratase/histidinol-phosphatase, len: 352 aa; similar to many e.g. HIS7_ECOLI histidine biosynthesis bifunctional protein HISB [includes: imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) (IGPD); histidinol-phosphatase (EC 3.1.3.15)] (355 aa),fasta scores; opt: 1385 z-score: 1653.6 E(): 0, 56.7% identity in 356 aa overlap. No Hp match. Contains PS00954 and PS00955 Imidazoleglycerol-phosphate dehydratase signatures 1 and 2, and Pfam match to entry PF00475 IGPD,Imidazoleglycerol-phosphate dehydratase; Updated [...] (352 aa)    
Predicted Functional Partners:
hisC
Original (2000) note: Cj0317, hisC, probable histidinol-phosphate aminotransferase, len: 364 aa; similar to many e.g. HIS8_BACSU histidinol-phosphate aminotransferase (EC 2.6.1.9) (360 aa), fasta scores; opt: 762 z-score: 1062.4 E(): 0, 36.2% identity in 367 aa overlap. No Hp match. Also similar to Cj1437c (hisC2) (30.0% identity in 347 aa overlap). Contains Pfam match to entry PF00222 aminotran_2, Aminotransferases class-II,score 60.80, E-value 2.9e-14; Updated (2006) note: Pfam domains PF00155 Aminotransferase class I and II were identified. Further support given to product function. [...]
 
 
 0.999
hisF
Imidazole glycerol phosphate synthase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).
 
 
 0.999
hisH
Imidazole glycerol phosphate synthase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity).
 
 
 0.999
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
 
  
 0.999
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
 
 0.999
hisH-2
Imidazole glycerol phosphate synthase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity).
 
 
 0.999
hisA
Original (2000) note: Cj1601, hisA, probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, len: 243 aa; similar to many e.g. HIS4_ECOLI phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16) (245 aa),fasta scores; opt: 778 z-score: 919.6 E(): 0, 50.6% identity in 243 aa overlap. No Hp match. Contains fam match to entry PF00977 His_biosynth, Histidine biosynthesis protein; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. Putative not added to product funciton. Functional classification -A [...]
 
 
 0.999
hisF-2
Imidazole glycerol phosphate synthase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).
 
 
 0.999
hisI
Original (2000) note: Cj1604, hisI, probable phosphoribosyl-AMP cyclohydrolase/ phosphoribosyl-ATP pyrophosphohydrolase, len: 207 aa; highly similar to many e.g. HIS2_ECOLI histidine biosynthesis bifunctional protein HisIE [includes: phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19); phosphoribosyl-ATP pyrophosphohydrolase (EC 3.6.1.31)] (203 aa), fasta scores; opt: 840 z-score: 1036.5 E(): 0, 63.4% identity in 205 aa overlap. No Hp match; Updated (2006) note: Pfam domains PF01502 Phosphoribosyl-AMP cyclohydrolase and PF01503 Phosphoribosyl-ATP pyrophosphohydrolase were identified within [...]
 
 
 0.999
Cj1437c
Aminotransferase; Original (2000) note: Cj1437c, probable aminotransferase, len: 367 aa; similar to e.g. HIS8_BACSU histidinol-phosphate aminotransferase (360 aa), fasta scores; opt: 408 z-score: 478.1 E(): 2.6e-19, 28.6% identity in 360 aa overlap. No Hp match. Also similar to Cj0317 (hisC) (29.9% identity in 344 aa overlap), and Cj1436c (23.3% identity in 347 aa overlap). Contains Pfam match to entry PF00222 aminotran_2, Aminotransferases class-II, and PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site; Updated (2006) note: Pfam domain PF00155 Aminotransferase cla [...]
 
 0.998
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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