node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cj1437c | hisA | Cj1437c | Cj1601 | Aminotransferase; Original (2000) note: Cj1437c, probable aminotransferase, len: 367 aa; similar to e.g. HIS8_BACSU histidinol-phosphate aminotransferase (360 aa), fasta scores; opt: 408 z-score: 478.1 E(): 2.6e-19, 28.6% identity in 360 aa overlap. No Hp match. Also similar to Cj0317 (hisC) (29.9% identity in 344 aa overlap), and Cj1436c (23.3% identity in 347 aa overlap). Contains Pfam match to entry PF00222 aminotran_2, Aminotransferases class-II, and PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site; Updated (2006) note: Pfam domain PF00155 Aminotransferase cla [...] | Original (2000) note: Cj1601, hisA, probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, len: 243 aa; similar to many e.g. HIS4_ECOLI phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16) (245 aa),fasta scores; opt: 778 z-score: 919.6 E(): 0, 50.6% identity in 243 aa overlap. No Hp match. Contains fam match to entry PF00977 His_biosynth, Histidine biosynthesis protein; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. Putative not added to product funciton. Functional classification -A [...] | 0.783 |
Cj1437c | hisB | Cj1437c | Cj1599 | Aminotransferase; Original (2000) note: Cj1437c, probable aminotransferase, len: 367 aa; similar to e.g. HIS8_BACSU histidinol-phosphate aminotransferase (360 aa), fasta scores; opt: 408 z-score: 478.1 E(): 2.6e-19, 28.6% identity in 360 aa overlap. No Hp match. Also similar to Cj0317 (hisC) (29.9% identity in 344 aa overlap), and Cj1436c (23.3% identity in 347 aa overlap). Contains Pfam match to entry PF00222 aminotran_2, Aminotransferases class-II, and PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site; Updated (2006) note: Pfam domain PF00155 Aminotransferase cla [...] | Original (2000) note: Cj1599, hisB, probable imidazoleglycerol-phosphate dehydratase/histidinol-phosphatase, len: 352 aa; similar to many e.g. HIS7_ECOLI histidine biosynthesis bifunctional protein HISB [includes: imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) (IGPD); histidinol-phosphatase (EC 3.1.3.15)] (355 aa),fasta scores; opt: 1385 z-score: 1653.6 E(): 0, 56.7% identity in 356 aa overlap. No Hp match. Contains PS00954 and PS00955 Imidazoleglycerol-phosphate dehydratase signatures 1 and 2, and Pfam match to entry PF00475 IGPD,Imidazoleglycerol-phosphate dehydratase; Updated [...] | 0.998 |
Cj1437c | hisD | Cj1437c | Cj1598 | Aminotransferase; Original (2000) note: Cj1437c, probable aminotransferase, len: 367 aa; similar to e.g. HIS8_BACSU histidinol-phosphate aminotransferase (360 aa), fasta scores; opt: 408 z-score: 478.1 E(): 2.6e-19, 28.6% identity in 360 aa overlap. No Hp match. Also similar to Cj0317 (hisC) (29.9% identity in 344 aa overlap), and Cj1436c (23.3% identity in 347 aa overlap). Contains Pfam match to entry PF00222 aminotran_2, Aminotransferases class-II, and PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site; Updated (2006) note: Pfam domain PF00155 Aminotransferase cla [...] | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.959 |
Cj1437c | hisF | Cj1437c | Cj1314c | Aminotransferase; Original (2000) note: Cj1437c, probable aminotransferase, len: 367 aa; similar to e.g. HIS8_BACSU histidinol-phosphate aminotransferase (360 aa), fasta scores; opt: 408 z-score: 478.1 E(): 2.6e-19, 28.6% identity in 360 aa overlap. No Hp match. Also similar to Cj0317 (hisC) (29.9% identity in 344 aa overlap), and Cj1436c (23.3% identity in 347 aa overlap). Contains Pfam match to entry PF00222 aminotran_2, Aminotransferases class-II, and PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site; Updated (2006) note: Pfam domain PF00155 Aminotransferase cla [...] | Imidazole glycerol phosphate synthase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.799 |
Cj1437c | hisF-2 | Cj1437c | Cj1603 | Aminotransferase; Original (2000) note: Cj1437c, probable aminotransferase, len: 367 aa; similar to e.g. HIS8_BACSU histidinol-phosphate aminotransferase (360 aa), fasta scores; opt: 408 z-score: 478.1 E(): 2.6e-19, 28.6% identity in 360 aa overlap. No Hp match. Also similar to Cj0317 (hisC) (29.9% identity in 344 aa overlap), and Cj1436c (23.3% identity in 347 aa overlap). Contains Pfam match to entry PF00222 aminotran_2, Aminotransferases class-II, and PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site; Updated (2006) note: Pfam domain PF00155 Aminotransferase cla [...] | Imidazole glycerol phosphate synthase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.808 |
Cj1437c | hisG | Cj1437c | Cj1597 | Aminotransferase; Original (2000) note: Cj1437c, probable aminotransferase, len: 367 aa; similar to e.g. HIS8_BACSU histidinol-phosphate aminotransferase (360 aa), fasta scores; opt: 408 z-score: 478.1 E(): 2.6e-19, 28.6% identity in 360 aa overlap. No Hp match. Also similar to Cj0317 (hisC) (29.9% identity in 344 aa overlap), and Cj1436c (23.3% identity in 347 aa overlap). Contains Pfam match to entry PF00222 aminotran_2, Aminotransferases class-II, and PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site; Updated (2006) note: Pfam domain PF00155 Aminotransferase cla [...] | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.777 |
Cj1437c | hisH | Cj1437c | Cj1315c | Aminotransferase; Original (2000) note: Cj1437c, probable aminotransferase, len: 367 aa; similar to e.g. HIS8_BACSU histidinol-phosphate aminotransferase (360 aa), fasta scores; opt: 408 z-score: 478.1 E(): 2.6e-19, 28.6% identity in 360 aa overlap. No Hp match. Also similar to Cj0317 (hisC) (29.9% identity in 344 aa overlap), and Cj1436c (23.3% identity in 347 aa overlap). Contains Pfam match to entry PF00222 aminotran_2, Aminotransferases class-II, and PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site; Updated (2006) note: Pfam domain PF00155 Aminotransferase cla [...] | Imidazole glycerol phosphate synthase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity). | 0.800 |
Cj1437c | hisH-2 | Cj1437c | Cj1600 | Aminotransferase; Original (2000) note: Cj1437c, probable aminotransferase, len: 367 aa; similar to e.g. HIS8_BACSU histidinol-phosphate aminotransferase (360 aa), fasta scores; opt: 408 z-score: 478.1 E(): 2.6e-19, 28.6% identity in 360 aa overlap. No Hp match. Also similar to Cj0317 (hisC) (29.9% identity in 344 aa overlap), and Cj1436c (23.3% identity in 347 aa overlap). Contains Pfam match to entry PF00222 aminotran_2, Aminotransferases class-II, and PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site; Updated (2006) note: Pfam domain PF00155 Aminotransferase cla [...] | Imidazole glycerol phosphate synthase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity). | 0.810 |
Cj1437c | hisI | Cj1437c | Cj1604 | Aminotransferase; Original (2000) note: Cj1437c, probable aminotransferase, len: 367 aa; similar to e.g. HIS8_BACSU histidinol-phosphate aminotransferase (360 aa), fasta scores; opt: 408 z-score: 478.1 E(): 2.6e-19, 28.6% identity in 360 aa overlap. No Hp match. Also similar to Cj0317 (hisC) (29.9% identity in 344 aa overlap), and Cj1436c (23.3% identity in 347 aa overlap). Contains Pfam match to entry PF00222 aminotran_2, Aminotransferases class-II, and PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site; Updated (2006) note: Pfam domain PF00155 Aminotransferase cla [...] | Original (2000) note: Cj1604, hisI, probable phosphoribosyl-AMP cyclohydrolase/ phosphoribosyl-ATP pyrophosphohydrolase, len: 207 aa; highly similar to many e.g. HIS2_ECOLI histidine biosynthesis bifunctional protein HisIE [includes: phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19); phosphoribosyl-ATP pyrophosphohydrolase (EC 3.6.1.31)] (203 aa), fasta scores; opt: 840 z-score: 1036.5 E(): 0, 63.4% identity in 205 aa overlap. No Hp match; Updated (2006) note: Pfam domains PF01502 Phosphoribosyl-AMP cyclohydrolase and PF01503 Phosphoribosyl-ATP pyrophosphohydrolase were identified within [...] | 0.997 |
hisA | Cj1437c | Cj1601 | Cj1437c | Original (2000) note: Cj1601, hisA, probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, len: 243 aa; similar to many e.g. HIS4_ECOLI phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16) (245 aa),fasta scores; opt: 778 z-score: 919.6 E(): 0, 50.6% identity in 243 aa overlap. No Hp match. Contains fam match to entry PF00977 His_biosynth, Histidine biosynthesis protein; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. Putative not added to product funciton. Functional classification -A [...] | Aminotransferase; Original (2000) note: Cj1437c, probable aminotransferase, len: 367 aa; similar to e.g. HIS8_BACSU histidinol-phosphate aminotransferase (360 aa), fasta scores; opt: 408 z-score: 478.1 E(): 2.6e-19, 28.6% identity in 360 aa overlap. No Hp match. Also similar to Cj0317 (hisC) (29.9% identity in 344 aa overlap), and Cj1436c (23.3% identity in 347 aa overlap). Contains Pfam match to entry PF00222 aminotran_2, Aminotransferases class-II, and PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site; Updated (2006) note: Pfam domain PF00155 Aminotransferase cla [...] | 0.783 |
hisA | hisB | Cj1601 | Cj1599 | Original (2000) note: Cj1601, hisA, probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, len: 243 aa; similar to many e.g. HIS4_ECOLI phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16) (245 aa),fasta scores; opt: 778 z-score: 919.6 E(): 0, 50.6% identity in 243 aa overlap. No Hp match. Contains fam match to entry PF00977 His_biosynth, Histidine biosynthesis protein; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. Putative not added to product funciton. Functional classification -A [...] | Original (2000) note: Cj1599, hisB, probable imidazoleglycerol-phosphate dehydratase/histidinol-phosphatase, len: 352 aa; similar to many e.g. HIS7_ECOLI histidine biosynthesis bifunctional protein HISB [includes: imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) (IGPD); histidinol-phosphatase (EC 3.1.3.15)] (355 aa),fasta scores; opt: 1385 z-score: 1653.6 E(): 0, 56.7% identity in 356 aa overlap. No Hp match. Contains PS00954 and PS00955 Imidazoleglycerol-phosphate dehydratase signatures 1 and 2, and Pfam match to entry PF00475 IGPD,Imidazoleglycerol-phosphate dehydratase; Updated [...] | 0.999 |
hisA | hisC | Cj1601 | Cj0317 | Original (2000) note: Cj1601, hisA, probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, len: 243 aa; similar to many e.g. HIS4_ECOLI phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16) (245 aa),fasta scores; opt: 778 z-score: 919.6 E(): 0, 50.6% identity in 243 aa overlap. No Hp match. Contains fam match to entry PF00977 His_biosynth, Histidine biosynthesis protein; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. Putative not added to product funciton. Functional classification -A [...] | Original (2000) note: Cj0317, hisC, probable histidinol-phosphate aminotransferase, len: 364 aa; similar to many e.g. HIS8_BACSU histidinol-phosphate aminotransferase (EC 2.6.1.9) (360 aa), fasta scores; opt: 762 z-score: 1062.4 E(): 0, 36.2% identity in 367 aa overlap. No Hp match. Also similar to Cj1437c (hisC2) (30.0% identity in 347 aa overlap). Contains Pfam match to entry PF00222 aminotran_2, Aminotransferases class-II,score 60.80, E-value 2.9e-14; Updated (2006) note: Pfam domains PF00155 Aminotransferase class I and II were identified. Further support given to product function. [...] | 0.755 |
hisA | hisD | Cj1601 | Cj1598 | Original (2000) note: Cj1601, hisA, probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, len: 243 aa; similar to many e.g. HIS4_ECOLI phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16) (245 aa),fasta scores; opt: 778 z-score: 919.6 E(): 0, 50.6% identity in 243 aa overlap. No Hp match. Contains fam match to entry PF00977 His_biosynth, Histidine biosynthesis protein; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. Putative not added to product funciton. Functional classification -A [...] | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.998 |
hisA | hisF | Cj1601 | Cj1314c | Original (2000) note: Cj1601, hisA, probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, len: 243 aa; similar to many e.g. HIS4_ECOLI phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16) (245 aa),fasta scores; opt: 778 z-score: 919.6 E(): 0, 50.6% identity in 243 aa overlap. No Hp match. Contains fam match to entry PF00977 His_biosynth, Histidine biosynthesis protein; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. Putative not added to product funciton. Functional classification -A [...] | Imidazole glycerol phosphate synthase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.965 |
hisA | hisF-2 | Cj1601 | Cj1603 | Original (2000) note: Cj1601, hisA, probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, len: 243 aa; similar to many e.g. HIS4_ECOLI phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16) (245 aa),fasta scores; opt: 778 z-score: 919.6 E(): 0, 50.6% identity in 243 aa overlap. No Hp match. Contains fam match to entry PF00977 His_biosynth, Histidine biosynthesis protein; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. Putative not added to product funciton. Functional classification -A [...] | Imidazole glycerol phosphate synthase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.993 |
hisA | hisG | Cj1601 | Cj1597 | Original (2000) note: Cj1601, hisA, probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, len: 243 aa; similar to many e.g. HIS4_ECOLI phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16) (245 aa),fasta scores; opt: 778 z-score: 919.6 E(): 0, 50.6% identity in 243 aa overlap. No Hp match. Contains fam match to entry PF00977 His_biosynth, Histidine biosynthesis protein; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. Putative not added to product funciton. Functional classification -A [...] | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.998 |
hisA | hisH | Cj1601 | Cj1315c | Original (2000) note: Cj1601, hisA, probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, len: 243 aa; similar to many e.g. HIS4_ECOLI phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16) (245 aa),fasta scores; opt: 778 z-score: 919.6 E(): 0, 50.6% identity in 243 aa overlap. No Hp match. Contains fam match to entry PF00977 His_biosynth, Histidine biosynthesis protein; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. Putative not added to product funciton. Functional classification -A [...] | Imidazole glycerol phosphate synthase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity). | 0.988 |
hisA | hisH-2 | Cj1601 | Cj1600 | Original (2000) note: Cj1601, hisA, probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, len: 243 aa; similar to many e.g. HIS4_ECOLI phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16) (245 aa),fasta scores; opt: 778 z-score: 919.6 E(): 0, 50.6% identity in 243 aa overlap. No Hp match. Contains fam match to entry PF00977 His_biosynth, Histidine biosynthesis protein; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. Putative not added to product funciton. Functional classification -A [...] | Imidazole glycerol phosphate synthase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity). | 0.997 |
hisA | hisI | Cj1601 | Cj1604 | Original (2000) note: Cj1601, hisA, probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, len: 243 aa; similar to many e.g. HIS4_ECOLI phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16) (245 aa),fasta scores; opt: 778 z-score: 919.6 E(): 0, 50.6% identity in 243 aa overlap. No Hp match. Contains fam match to entry PF00977 His_biosynth, Histidine biosynthesis protein; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. Putative not added to product funciton. Functional classification -A [...] | Original (2000) note: Cj1604, hisI, probable phosphoribosyl-AMP cyclohydrolase/ phosphoribosyl-ATP pyrophosphohydrolase, len: 207 aa; highly similar to many e.g. HIS2_ECOLI histidine biosynthesis bifunctional protein HisIE [includes: phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19); phosphoribosyl-ATP pyrophosphohydrolase (EC 3.6.1.31)] (203 aa), fasta scores; opt: 840 z-score: 1036.5 E(): 0, 63.4% identity in 205 aa overlap. No Hp match; Updated (2006) note: Pfam domains PF01502 Phosphoribosyl-AMP cyclohydrolase and PF01503 Phosphoribosyl-ATP pyrophosphohydrolase were identified within [...] | 0.999 |
hisB | Cj1437c | Cj1599 | Cj1437c | Original (2000) note: Cj1599, hisB, probable imidazoleglycerol-phosphate dehydratase/histidinol-phosphatase, len: 352 aa; similar to many e.g. HIS7_ECOLI histidine biosynthesis bifunctional protein HISB [includes: imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) (IGPD); histidinol-phosphatase (EC 3.1.3.15)] (355 aa),fasta scores; opt: 1385 z-score: 1653.6 E(): 0, 56.7% identity in 356 aa overlap. No Hp match. Contains PS00954 and PS00955 Imidazoleglycerol-phosphate dehydratase signatures 1 and 2, and Pfam match to entry PF00475 IGPD,Imidazoleglycerol-phosphate dehydratase; Updated [...] | Aminotransferase; Original (2000) note: Cj1437c, probable aminotransferase, len: 367 aa; similar to e.g. HIS8_BACSU histidinol-phosphate aminotransferase (360 aa), fasta scores; opt: 408 z-score: 478.1 E(): 2.6e-19, 28.6% identity in 360 aa overlap. No Hp match. Also similar to Cj0317 (hisC) (29.9% identity in 344 aa overlap), and Cj1436c (23.3% identity in 347 aa overlap). Contains Pfam match to entry PF00222 aminotran_2, Aminotransferases class-II, and PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site; Updated (2006) note: Pfam domain PF00155 Aminotransferase cla [...] | 0.998 |