STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ispDF2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF); In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. (371 aa)    
Predicted Functional Partners:
ispE
Putative 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
 
 
 0.987
ispG
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family.
 
 
 0.985
dxr
1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family.
 
  
 0.970
Cj1609
Original (2000) note: Cj1609, possible sulfate adenylyltransferase, len: 386 aa; similar to e.g. TR:O34764 (EMBL:) BAcillus subtilis putative sulfate adenylyltransferase (382 aa), fasta scores; opt: 360 z-score: 414.1 E(): 9.6e-16, 23.4% identity in 351 aa overlap, and TR:O66036 (EMBL:U84759) Chromatium vinosum sulfate adenylyltransferase (EC 2.7.7.4) (397 aa), fasta scores; opt: 273 z-score: 315.2 E(): 3.1e-10, 21.8% identity in 357 aa overlap. No Hp match; Updated (2006) note: No specific characterisation with acceptable identity score carried out yet. Putative kept within product fu [...]
  
  
 0.902
fliN
Original (2000) note: Cj0351, fliN, flagellar motor switch protein, len: 102 aa; identical to TR:O32370 (EMBL:AJ000400), and similar to many e.g. FLIN_ECOLI flagellar motor switch protein FLIN (137 aa), fasta scores; opt: 196 z-score: 359.1 E(): 9.5e-13, 36.0% identity in 89 aa overlap. 53.4% identity to HP0584; Updated (2006) note: Pfam PF01052 Surface presentation of antigens (SPOA) protein identified within CDS. Further support given to product function. Characterisation paper identified within Campylobacter jejuni and also Escherichia coli. Putative not added to product function. F [...]
   
   0.899
ispH
4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family.
 
   
 0.895
Cj1608
Original (2000) note: Cj1608, possible two-component regulator, len: 295 aa, some similarity to regulatory components of tw-component systems e.g. TR:O87527 (EMBL:AF082668) Streptococcus pyogenes capsule synthesis regulator CSRR (228 aa), fasta scores; opt: 170 z-score: 203.9 E(): 0.00049, 35.0% identity in 123 aa overlap, and BASR_ECOLI transcriptional regulatory protein (222 aa), blastp scores; E = 1.6e-06 29% identity in 113 aa overlap. 33.8% identity to HP1021. Contains helix-turn-helix motif at aa 271-292 (Score 997, +2.58 SD). Also some similarity to Cj1024c (22.0% identity in 34 [...]
  
  
 0.880
dxs
L-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily.
 
  
 0.863
trmD
tRNA (guanine-N1)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family.
  
   0.845
Cj0631c
Putative ribonuclease; Original (2000) note: Cj0631c, possible ribonuclease, len: 644 aa; similar to members of the ribonuclease II (RNB) family, e.g. VACB_ECOLI VACB protein (813 aa), fasta scores; opt: 503 z-score: 829.1 E(): 0,31.0% identity in 580 aa overlap. 35.1% identity to HP1248. Contains PS01175 Ribonuclease II family signature,and Pfam match to entry PF00773 RNB, RNB-like proteins; Updated (2006) note: Some characterisation within Escherichia coli, however, identity scores were marginal. Putative kept within product function. Functional classification - Degradation of macrom [...]
  
   0.825
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Server load: medium (66%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.