STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (414 aa)    
Predicted Functional Partners:
pgk
Phosphoglycerate kinase; Original (2000) note: Cj1402c, pgk,phosphoglycerate kinase, len: 400 aa; similar to e.g. PGK_AQUAE phosphoglycerate kinase (EC 2.7.2.3) (397 aa),fasta scores; opt: 1417 z-score: 1610.9 E(): 0, 53.4% identity in 393 aa overlap, and PGKY_WHEAT phosphoglycerate kinase, cytosolic (401 aa), fasta scores; opt: 1369 z-score: 1556.5 E(): 0, 53.1% identity in 392 aa overlap. 49.1% identity to HP1345. Contains PS00111 Phosphoglycerate kinase signature, and Pfam match to entry PF00162 PGK, Phosphoglycerate kinases; Updated (2006) note: Characterisation work carried out in [...]
 
 
 0.998
gapA
Original (2000) note: Cj1403c, gapA, glyceraldehyde 3-phosphate dehydrogenase, len: 332 aa; similar to e.g. G3P1_BACSU glyceraldehyde 3-phosphate dehydrogenase 1 (334 aa), fasta scores; opt: 1070 z-score: 1216.4 E(): 0, 50.3% identity in 332 aa overlap. 45.6% identity to HP1346 and 46.7% identity to HP0921. Contains Pfam match to entry PF00044 gpdh, glyceraldehyde 3-phosphate dehydrogenases,and PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site; Updated (2006) note: Pfam domains PF02800 and PF00044 Glyceraldehyde 3-phosphate dehydrogenase,C-terminal and N-terminal were both i [...]
 
 0.997
tpiA
Putative triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.
 
 
 0.995
pyk
Pyruvate kinase; Original (2000) note: Cj0392c, pyk, probable pyruvate kinase, len: 480 aa; similar to e.g. KPYK_BACSU pyruvate kinase (EC 2.7.1.40) (585 aa), fasta scores; opt: 1111 z-score: 1494.8 E(): 0, 41.8% identity in 476 aa overlap. No Hp match. Contains PS00659 Glycosyl hydrolases family 5 signature and Pfam match to entry PF00224 PK,Pyruvate kinase, score 523.20, E-value 1.8e-153; Updated (2006) note: Pfam domain PF02887 Pyruvate kinase, alpha/beta domain protein was identified within CDS. Further support given to product function. Characterised within Bacillus subtilis with [...]
 
 0.984
pgm
2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate.
  
 0.977
rplD
50S ribosomal protein L4; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).
  
 
 0.961
fba
Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
   
 0.958
pgi
Original (2000) note: Cj1535c, pgi, possible glucose-6-phosphate isomerase, len: 406 aa; similar to e.g. G6PI_BACSU glucose-6-phosphate isomerase (EC 5.3.1.9) (450 aa), fats scores; opt: 469 z-score: 569.6 E(): 2.1e-24, 29.3% identity in 382 aa overlap. 26.1% identity to HP1166. Contains PS00174 Phosphoglucose isomerase signature 2, and Pfam match to entry PF00342 PGI,Phosphoglucose isomerase; Updated (2006) note: Some characterisation has been carried out with different genus, however, not matching with acceptable identity score, so putative kept within product function. Functional cl [...]
  
 0.947
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
   
 
 0.917
dnaK
Heat shock protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
   
 
 0.903
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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