DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]

DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]

Putative DNA repair protein; May be involved in recombinational repair of damaged DNA.

ATP-dependent DNA helicase; Original (2000) note: Cj1101, probable ATP-dependent DNA helicase, len: 691 aa; similar to many e.g REP_ECOLI ATP-dependent DNA helicase REP (EC 3.6.1.-) (673 aa), fasta scores; opt: 977 z-score: 1067.3 E(): 0,36.9% identity in 640 aa overlap, and UVRD_ECOLI DNA helicase II (EC 3.6.1.-) (720 aa), fasta scores; opt: 1129 z-score: 1232.6 E(): 0, 35.2% identity in 714 aa overlap. 43.7% identity to HP1478. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and Pfam match to entry PF00580 UvrD-helicase, UvrD/REP helicase; Updated (2006) note: Similar to more [...]

Hypothetical protein Cj0584; Original (2000) note: Cj0584, unknown, len: 199 aa; 36.3% identity to HP1231 (annotated as DNA polymerase III delta prime subunit (holB)). No significant similarity to other holB proteins. Functional classification - Conserved hypothetical proteins.

Original (2000) note: Cj0777, probable ATP-dependent DNA helicase, len: 676 aa; similar to many members of the uvrD family of helicases, e.g. PCRA_STAAU ATP-dependent helicase PCRA (675 aa), fasta scores; opt: 561 z-score: 634.4 E(): 4.9e-28, 29.0% identity in 694 aa overlap, and REP_ECOLI ATP-dependent DNA helicase REP (673 aa), fasta scores; opt: 423 z-score: 478.5 E(): 2.4e-19,27.3% identity in 682 aa overlap. 47.5% identity to HP0911. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and Pfam match to entry PF00580 UvrD-helicase,UvrD/REP helicase; Updated (2006) note: Characte [...]

DNA processing protein A; Original (2000) note: Cj0634, unknown, len: 257 aa; similar, in part, to members of the SMF family e.g. SMF_HAEIN SMF protein (DNA processing chain A) (373 aa),fasta scores; opt: 329 z-score: 487.6 E(): 7.2e-20, 31.5% identity in 213 aa overlap. 48.8% identity to HP0333; Updated (2006) note: Pfam domain PF02481 SMF family identified within CDS. Further support given to product function. Literature search identified Campylobacter jejuni characterising paper. Product modified to more specific family member. Functional classification - DNA replication, restrictio [...]

DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

Putative DNA repair protein RadA (ATP-dependant protease); DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. Belongs to the RecA family. RadA subfamily.