STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
bioBPutative biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (278 aa)    
Predicted Functional Partners:
bioD
Putative dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.
 
 
 0.994
bioA
Original (2000) note: Cj0307, bioA, probable adenosylmethionine-8-amino-7-oxononanoate aminotransferase, len: 427 aa; similar to many e.g. BIOA_ECOLI adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62) (429 aa), fasta scores; opt: 882 z-score: 1095.3 E(): 0, 35.8% identity in 411 aa overlap. 57.8% identity to HP0976. Contains PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site and Pfam match to entry PF00202 aminotran_3,Aminotransferases class-III pyridoxal-phosphate, score 383.00, E-value 1.1e-132; Updated (2006) note: Characterised within Esch [...]
  
 0.986
bioF
8-amino-7-oxononanoate synthase; Original (2000) note: Cj0306c, bioF, probable 8-amino-7-oxononanoate synthase, len: 380 aa; similar to many e.g. BIOF_ECOLI 8-amino-7-oxononanoate synthase (EC 2.3.1.47) (384 aa), fasta scores; opt: 525 z-score: 550.3 E(): 2.1e-23, 28.9% identity in 387 aa overlap. 29.0% identity to HP0598. Contains PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site and Pfam match to entry PF00222 aminotran_2, Aminotransferases class-II, score 196.30, E-value 4.7e-55; Updated (2006) note: Characterised within Escherichia coli with marginal identity s [...]
 
 0.952
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
  
 0.830
Cj1684c
Original (2000) note: Cj1684c, probable transmembrane transport protein, len: 391 aa; simlar to many predicted Na+/H+ antiporters, and to KEFB_ECOLI Glutathione-regulated potassium-efflux system protein (601 aa), fasta scores; opt: 197 z-score: 237.9 E(): 6.2e-06,21.9% identity in 324 aa overlap, and NAPA_ENTHR Na(+)/H(+) antiporter (383 aa), blastp scores; E= 3.1e-10,22% identity in 372 aa overlap. 35.9% identity to HP1183 (called NA+/H+ antiporter (napA) on basis of match to NAPA_ENTHR); Updated (2006) note: Eleven probable transmembrane helices predicted by TMHMM2.0. Further support [...]
  
    0.807
birA
Original (2000) note: Cj0099, birA, possible biotin--[acetyl-CoA-carboxylase] synthetase, len: 217 aa; weak similarity to e.g. SW:BIRA_BACSU P42975 birA bifunctional protein (biotin operon repressor) (biotin--[acetyl-CoA-carboxylase] synthetase) (EC 6.3.4.15)(325 aa), blastp scores; E= 0.00011, 21% identity in 163 aa overlap; similarity does not include DNA-binding domain. 39.0% identity to HP1140; Updated (2006) note: Pfam domain PF03099 Biotin/lipoate A/B protein ligase family identified within CDS. Further support given to product function. Specific characterisation with acceptable [...]
  
 
 0.686
argD
Putative acetylornithine/succinyldiaminopimelate aminotransferase; Original (2000) note: Cj0227, argD, probable acetylornithine aminotransferase, len: 395 aa; simlar to many e.g. ARGD_ECOLI acetylornithine aminotransferase (EC 2.6.1.11) (406 aa), fasta scores; opt: 921 z-score: 1042.0 E(): 0, 36.6% identity in 385 aa overlap. No Hp ortholog. Contains Pfam match to entry PF00202 aminotran_3,Aminotransferases class-III pyridoxal-phosphate, score 378.20, E-value 5.1e-131; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. Based on current literature [...]
 
 
 
 0.670
pabB
Original (2000) note: Cj0862c, pabB, probable para-aminobenzoate synthase component I, len: 594 aa; simlar to e.g. PABB_ECOLI para-aminobenzoate synthase component I (EC 4.1.3.-) (453 aa), fasta scores; opt: 541 z-score: 604.3 E(): 2.3e-26, 35.7% identity in 252 aa overlap. 39.3% identity to HP0293. Contains Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme; Updated (2006) note: Characterised in Escherichia coli with acceptable identity score. Putative not added to product function. Functional classification - Biosynthesis of cofactors, prosthetic groups and carrie [...]
     
 0.617
gltA
Citrate synthase; Original (2000) note: Cj1682c, gltA, probable citrate synthase, len: 422 aa; similar to many e.g. CISY_PSEAE citrate synthase (EC 4.1.3.7) (428 aa), fasta scores; opt: 1520 z-score: 1734.6 E(): 0, 53.8% identity in 405 aa overlap. 52.8% identity to HP0026. Contains PS00480 Citrate synthase signature, and Pfam match to entry PF00285 citrate_synt, Citrate synthase; Updated (2006) note: Characterised within Pseudomonas aeruginosa with acceptable identity score. Appropriate motifs present. Putative not added to product function. EC number has been updated. Functional clas [...]
     
 0.611
carB
Original (2000) note: Cj0279, carB, probable carbamoyl-phosphate synthase large chain, len: 1089 aa; highly similar to many e.g. CARB_ECOLI carbamoyl-phosphate synthase large chain (EC 6.3.5.5) (1072 aa), fasta scores; opt: 3268 z-score: 4517.4 E(): 0, 55.3% identity in 1098 aa overlap. 62.5% identity to HP0919. Contains 2x PS00866 Carbamoyl-phosphate synthase subdomain signature 1, 2x PS00867 Carbamoyl-phosphate synthase subdomain signature 2, and 2x Pfam match to entry PF00289 CPSase_L_chain,Carbamoyl-phosphate synthase (CPSase). Also contains apparent N-terminal signal sequence with [...]
  
 
 0.597
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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