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cbiX protein (Methanosarcina mazei) - STRING interaction network
"cbiX" - Sirohydrochlorin cobaltochelatase in Methanosarcina mazei
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Predicted Interactions
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gene co-occurrence
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textmining
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protein homology
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cbiXSirohydrochlorin cobaltochelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl- coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin (130 aa)    
Predicted Functional Partners:
MM_0513
Cobyrinate a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source (498 aa)
       
  0.996
MM_0999
annotation not available (202 aa)
 
   
  0.981
MM_0516
annotation not available (483 aa)
 
     
  0.966
MM_1740
annotation not available (223 aa)
       
  0.961
hemA
Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA); Belongs to the glutamyl-tRNA reductase family (448 aa)
 
   
  0.947
cbiT
Probable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating); Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin- 7 (184 aa)
         
  0.944
cobS
Adenosylcobinamide-GDP ribazoletransferase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5’-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5’-phosphate; Belongs to the CobS family (280 aa)
         
  0.943
cobQ
Probable cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (499 aa)
         
  0.942
hemC
Probable porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (316 aa)
         
  0.941
ribH
6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (134 aa)
 
     
  0.921
Your Current Organism:
Methanosarcina mazei
NCBI taxonomy Id: 192952
Other names: M. mazei Go1, Methanosarcina mazei, Methanosarcina mazei Go1, Methanosarcina mazei str. Go1, Methanosarcina mazei strain Go1
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