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purP1 protein (Methanosarcina mazei) - STRING interaction network
"purP1" - 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase 1 in Methanosarcina mazei
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
purP15-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5’-monophosphate synthetase 1; Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5’- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5’-monophosphate (FAICAR) in the absence of folates; Belongs to the phosphohexose mutase family (356 aa)    
Predicted Functional Partners:
MM_0941
annotation not available (452 aa)
 
   
  0.944
MM_0898
Formyltransferase phosphoribosylaminoimidazolecarboxamide; IMP cyclohydrolase (538 aa)
         
  0.909
hpt
Hypoxanthine/guanine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis; Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily (189 aa)
       
  0.908
MM_0593
annotation not available (387 aa)
 
   
 
0.823
purP2
5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5’-monophosphate synthetase 2; Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5’- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5’-monophosphate (FAICAR) in the absence of folates; Belongs to the phosphohexose mutase family (356 aa)
   
   
 
0.801
hisH
Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (207 aa)
         
    0.800
hisF
Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (273 aa)
         
    0.800
MM_1312
annotation not available (159 aa)
   
     
  0.594
mch
Methenyltetrahydromethanopterin cyclohydrolase; Catalyzes the reversible interconversion of 5-formyl- H(4)MPT to methenyl-H(4)MPT(+); Belongs to the MCH family (321 aa)
           
  0.569
pfdB
Prefoldin subunit beta; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding (117 aa)
   
          0.566
Your Current Organism:
Methanosarcina mazei
NCBI taxonomy Id: 192952
Other names: M. mazei Go1, Methanosarcina mazei, Methanosarcina mazei Go1, Methanosarcina mazei str. Go1, Methanosarcina mazei strain Go1
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