node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CT1763 | CT2238 | CT1763 | CT2238 | uroporphyrin-III C-methyltransferase; Identified by similarity to EGAD:6870; match to protein family HMM PF00590. | Siroheme synthetase, putative; Identified by similarity to EGAD:14346; match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | 0.936 |
CT1763 | cbiDJ | CT1763 | CT0384 | uroporphyrin-III C-methyltransferase; Identified by similarity to EGAD:6870; match to protein family HMM PF00590. | precorrin-6X reductase/cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | 0.652 |
CT1763 | cobA | CT1763 | CT0390 | uroporphyrin-III C-methyltransferase; Identified by similarity to EGAD:6870; match to protein family HMM PF00590. | uroporphyrin-III C-methyltransferase; Identified by similarity to EGAD:12949; match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | 0.921 |
CT1763 | hemA | CT1763 | CT1426 | uroporphyrin-III C-methyltransferase; Identified by similarity to EGAD:6870; match to protein family HMM PF00590. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.414 |
CT1763 | hemB | CT1763 | CT1431 | uroporphyrin-III C-methyltransferase; Identified by similarity to EGAD:6870; match to protein family HMM PF00590. | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family. | 0.623 |
CT1763 | hemC | CT1763 | CT1427 | uroporphyrin-III C-methyltransferase; Identified by similarity to EGAD:6870; match to protein family HMM PF00590. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. | 0.664 |
CT1763 | hemD | CT1763 | CT1428 | uroporphyrin-III C-methyltransferase; Identified by similarity to EGAD:6870; match to protein family HMM PF00590. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.944 |
CT1763 | hemE | CT1763 | CT2039 | uroporphyrin-III C-methyltransferase; Identified by similarity to EGAD:6870; match to protein family HMM PF00590. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.911 |
CT2238 | CT1763 | CT2238 | CT1763 | Siroheme synthetase, putative; Identified by similarity to EGAD:14346; match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | uroporphyrin-III C-methyltransferase; Identified by similarity to EGAD:6870; match to protein family HMM PF00590. | 0.936 |
CT2238 | cbiDJ | CT2238 | CT0384 | Siroheme synthetase, putative; Identified by similarity to EGAD:14346; match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | precorrin-6X reductase/cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | 0.799 |
CT2238 | cbiP | CT2238 | CT0938 | Siroheme synthetase, putative; Identified by similarity to EGAD:14346; match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.485 |
CT2238 | cobA | CT2238 | CT0390 | Siroheme synthetase, putative; Identified by similarity to EGAD:14346; match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | uroporphyrin-III C-methyltransferase; Identified by similarity to EGAD:12949; match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | 0.925 |
CT2238 | hemA | CT2238 | CT1426 | Siroheme synthetase, putative; Identified by similarity to EGAD:14346; match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.826 |
CT2238 | hemB | CT2238 | CT1431 | Siroheme synthetase, putative; Identified by similarity to EGAD:14346; match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family. | 0.981 |
CT2238 | hemC | CT2238 | CT1427 | Siroheme synthetase, putative; Identified by similarity to EGAD:14346; match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. | 0.999 |
CT2238 | hemD | CT2238 | CT1428 | Siroheme synthetase, putative; Identified by similarity to EGAD:14346; match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.931 |
CT2238 | hemE | CT2238 | CT2039 | Siroheme synthetase, putative; Identified by similarity to EGAD:14346; match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.948 |
CT2238 | hemL | CT2238 | CT2099 | Siroheme synthetase, putative; Identified by similarity to EGAD:14346; match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | Glutamate-1-semialdehyde 2,1-aminomutase; Identified by similarity to EGAD:19989; match to protein family HMM PF00202; match to protein family HMM TIGR00713; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. | 0.628 |
cbiDJ | CT1763 | CT0384 | CT1763 | precorrin-6X reductase/cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | uroporphyrin-III C-methyltransferase; Identified by similarity to EGAD:6870; match to protein family HMM PF00590. | 0.652 |
cbiDJ | CT2238 | CT0384 | CT2238 | precorrin-6X reductase/cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Siroheme synthetase, putative; Identified by similarity to EGAD:14346; match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | 0.799 |