node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CPF_2123 | CPF_2633 | CPF_2123 | CPF_2633 | Methenyltetrahydrofolate cyclohydrolase; Identified by match to protein family HMM PF04961. | Identified by match to protein family HMM PF01812; match to protein family HMM TIGR02727; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.921 |
CPF_2123 | fhs | CPF_2123 | CPF_2785 | Methenyltetrahydrofolate cyclohydrolase; Identified by match to protein family HMM PF04961. | Formate--tetrahydrofolate ligase; Identified by similarity to SP:P13419; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | 0.973 |
CPF_2123 | fmt | CPF_2123 | CPF_1005 | Methenyltetrahydrofolate cyclohydrolase; Identified by match to protein family HMM PF04961. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.912 |
CPF_2123 | fmt-2 | CPF_2123 | CPF_1996 | Methenyltetrahydrofolate cyclohydrolase; Identified by match to protein family HMM PF04961. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.912 |
CPF_2123 | folD | CPF_2123 | CPF_2077 | Methenyltetrahydrofolate cyclohydrolase; Identified by match to protein family HMM PF04961. | folD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.966 |
CPF_2123 | purH | CPF_2123 | CPF_0677 | Methenyltetrahydrofolate cyclohydrolase; Identified by match to protein family HMM PF04961. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Identified by similarity to SP:P12048; match to protein family HMM PF01808; match to protein family HMM PF02142; match to protein family HMM TIGR00355. | 0.906 |
CPF_2123 | purN | CPF_2123 | CPF_0676 | Methenyltetrahydrofolate cyclohydrolase; Identified by match to protein family HMM PF04961. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.911 |
CPF_2633 | CPF_2123 | CPF_2633 | CPF_2123 | Identified by match to protein family HMM PF01812; match to protein family HMM TIGR02727; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Methenyltetrahydrofolate cyclohydrolase; Identified by match to protein family HMM PF04961. | 0.921 |
CPF_2633 | folD | CPF_2633 | CPF_2077 | Identified by match to protein family HMM PF01812; match to protein family HMM TIGR02727; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | folD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.929 |
CPF_2633 | purN | CPF_2633 | CPF_0676 | Identified by match to protein family HMM PF01812; match to protein family HMM TIGR02727; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.927 |
fhs | CPF_2123 | CPF_2785 | CPF_2123 | Formate--tetrahydrofolate ligase; Identified by similarity to SP:P13419; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Methenyltetrahydrofolate cyclohydrolase; Identified by match to protein family HMM PF04961. | 0.973 |
fhs | folD | CPF_2785 | CPF_2077 | Formate--tetrahydrofolate ligase; Identified by similarity to SP:P13419; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | folD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.997 |
fhs | glyA | CPF_2785 | CPF_2184 | Formate--tetrahydrofolate ligase; Identified by similarity to SP:P13419; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.976 |
fhs | purH | CPF_2785 | CPF_0677 | Formate--tetrahydrofolate ligase; Identified by similarity to SP:P13419; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Identified by similarity to SP:P12048; match to protein family HMM PF01808; match to protein family HMM PF02142; match to protein family HMM TIGR00355. | 0.975 |
fhs | purN | CPF_2785 | CPF_0676 | Formate--tetrahydrofolate ligase; Identified by similarity to SP:P13419; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.966 |
fhs | thyX | CPF_2785 | CPF_2735 | Formate--tetrahydrofolate ligase; Identified by similarity to SP:P13419; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.903 |
fmt | CPF_2123 | CPF_1005 | CPF_2123 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Methenyltetrahydrofolate cyclohydrolase; Identified by match to protein family HMM PF04961. | 0.912 |
fmt | fmt-2 | CPF_1005 | CPF_1996 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.903 |
fmt | folD | CPF_1005 | CPF_2077 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | folD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.949 |
fmt | glyA | CPF_1005 | CPF_2184 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.929 |