STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
BD01_1983Putative hydrolase (metallo-beta-lactamase superfamily); COG2248; Belongs to the UPF0282 family. (299 aa)    
Predicted Functional Partners:
nep1
Hypothetical protein; Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.
 
     0.552
BD01_1982
Hypothetical protein.
       0.507
BD01_0820
Putative nucleotidyltransferase; COG2413.
  
     0.492
BD01_0472
Putative RNA-binding protein, contains THUMP domain; COG1818.
  
     0.475
rpl18a
Ribosomal protein LXA (rplXA).
  
   
 0.467
BD01_1645
Uncharacterized protein conserved in archaea; COG2090.
  
   
 0.466
rpl14e
Ribosomal protein L14E (rpl14E); Belongs to the eukaryotic ribosomal protein eL14 family.
  
     0.452
BD01_0369
DNA helicase TIP49, TBP-interacting protein; COG1224.
  
     0.421
rgy
Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
  
     0.420
BD01_2039
Putative GTPase or GTP-binding protein; COG1341.
  
     0.416
Your Current Organism:
Thermococcus nautili
NCBI taxonomy Id: 195522
Other names: CNCM 4275, JCM 19601, T. nautili, Thermococcus nautili Gorlas et al. 2014, Thermococcus nautilus, Thermococcus sp. 30-1, strain 30-1
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