STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Noca_0157DNA-(apurinic or apyrimidinic site) lyase / Formamidopyrimidine-DNA glycosylase; PFAM: Formamidopyrimidine-DNA glycolase; KEGG: lxx:Lxx00140 formamidopyrimidine-DNA glycosylase; Belongs to the FPG family. (288 aa)    
Predicted Functional Partners:
mutM
DNA-(apurinic or apyrimidinic site) lyase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
  
  
0.932
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.862
Noca_2328
PFAM: Formamidopyrimidine-DNA glycolase; KEGG: mpa:MAP3416 probable endonuclease VIII.
  
   
 0.843
Noca_0156
PFAM: Rhodanese domain protein; KEGG: sco:SCO3839 hypothetical protein.
       0.768
Noca_2659
PFAM: 5'-3' exonuclease; SMART: Helix-hairpin-helix domain protein, class 2; KEGG: sma:SAV6714 putative 5'-3' exonuclease.
 
  
 0.684
coaE
dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.
 
  
 0.638
Noca_2964
PFAM: HhH-GPD family protein; KEGG: mbo:Mb1187 hypothetical protein.
  
  
 0.583
Noca_0907
PFAM: ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: sma:SAV1697 putative DNA ligase.
 
  
 0.565
Noca_3128
DNA polymerase III, epsilon subunit; KEGG: fal:FRAAL5108 putative DNA-directed DNA polymerase; TIGRFAM: DNA polymerase III, epsilon subunit; PFAM: Excinuclease ABC, C subunit domain protein; UvrB/UvrC protein; Exonuclease, RNase T and DNA polymerase III; SMART: Exonuclease.
  
  
 0.563
Noca_1522
PFAM: PHP C-terminal domain protein; SMART: phosphoesterase PHP domain protein; KEGG: nfa:nfa41810 hypothetical protein.
 
   
 0.559
Your Current Organism:
Nocardioides sp. JS614
NCBI taxonomy Id: 196162
Other names: N. sp. JS614
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