STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Noca_0418RNase HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (143 aa)    
Predicted Functional Partners:
Noca_2015
PFAM: ribonuclease H; Phosphoglycerate mutase; KEGG: sma:SAV5877 hypothetical protein.
  
 
 0.918
rnhB
Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.
  
 
 0.703
Noca_2013
PFAM: protein of unknown function DUF34; KEGG: rha:RHA1_ro01183 hypothetical protein; Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
  
  
 0.680
Noca_4559
Prolyl aminopeptidase 2, Serine peptidase, MEROPS family S33; PFAM: alpha/beta hydrolase fold; KEGG: sco:SCO0805 prolyl aminopeptidase.
      0.676
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
 
 
 
 0.563
Noca_0419
PFAM: Endonuclease/exonuclease/phosphatase.
       0.554
Noca_2014
PFAM: protein of unknown function DUF164; KEGG: fal:FRAAL2220 conserved hypothetical protein; putative coiled-coil domain.
  
  
 0.554
Noca_0417
KEGG: sma:SAV6755 hypothetical protein.
       0.550
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
   
 
 0.534
Noca_1516
ATP-dependent DNA helicase, Rep family; PFAM: UvrD/REP helicase; HRDC domain protein; KEGG: sco:SCO5188 putative ATP-dependent DNA helicase.
  
 
 0.484
Your Current Organism:
Nocardioides sp. JS614
NCBI taxonomy Id: 196162
Other names: N. sp. JS614
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