node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Noca_2307 | Noca_2631 | Noca_2307 | Noca_2631 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: fra:Francci3_3132 glycine cleavage system T protein. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.951 |
Noca_2307 | fmt | Noca_2307 | Noca_2442 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: fra:Francci3_3132 glycine cleavage system T protein. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.949 |
Noca_2307 | folD1 | Noca_2307 | Noca_0641 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: fra:Francci3_3132 glycine cleavage system T protein. | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.943 |
Noca_2307 | folD2 | Noca_2307 | Noca_3582 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: fra:Francci3_3132 glycine cleavage system T protein. | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.943 |
Noca_2307 | glyA | Noca_2307 | Noca_2352 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: fra:Francci3_3132 glycine cleavage system T protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.998 |
Noca_2307 | purN | Noca_2307 | Noca_3584 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: fra:Francci3_3132 glycine cleavage system T protein. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.950 |
Noca_2443 | Noca_2631 | Noca_2443 | Noca_2631 | PFAM: Fmu (Sun) domain protein; NusB/RsmB/TIM44; KEGG: sco:SCO1472 conserved hypothetical Sun-family protein SCL6.29c; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.751 |
Noca_2443 | def | Noca_2443 | Noca_2441 | PFAM: Fmu (Sun) domain protein; NusB/RsmB/TIM44; KEGG: sco:SCO1472 conserved hypothetical Sun-family protein SCL6.29c; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. | 0.807 |
Noca_2443 | fmt | Noca_2443 | Noca_2442 | PFAM: Fmu (Sun) domain protein; NusB/RsmB/TIM44; KEGG: sco:SCO1472 conserved hypothetical Sun-family protein SCL6.29c; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.989 |
Noca_2443 | folD1 | Noca_2443 | Noca_0641 | PFAM: Fmu (Sun) domain protein; NusB/RsmB/TIM44; KEGG: sco:SCO1472 conserved hypothetical Sun-family protein SCL6.29c; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.751 |
Noca_2443 | folD2 | Noca_2443 | Noca_3582 | PFAM: Fmu (Sun) domain protein; NusB/RsmB/TIM44; KEGG: sco:SCO1472 conserved hypothetical Sun-family protein SCL6.29c; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.751 |
Noca_2443 | metG | Noca_2443 | Noca_1386 | PFAM: Fmu (Sun) domain protein; NusB/RsmB/TIM44; KEGG: sco:SCO1472 conserved hypothetical Sun-family protein SCL6.29c; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.401 |
Noca_2443 | priA | Noca_2443 | Noca_2440 | PFAM: Fmu (Sun) domain protein; NusB/RsmB/TIM44; KEGG: sco:SCO1472 conserved hypothetical Sun-family protein SCL6.29c; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | Primosomal protein N' (replication factor Y) (superfamily II helicase); Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. | 0.789 |
Noca_2443 | purN | Noca_2443 | Noca_3584 | PFAM: Fmu (Sun) domain protein; NusB/RsmB/TIM44; KEGG: sco:SCO1472 conserved hypothetical Sun-family protein SCL6.29c; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.463 |
Noca_2631 | Noca_2307 | Noca_2631 | Noca_2307 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: fra:Francci3_3132 glycine cleavage system T protein. | 0.951 |
Noca_2631 | Noca_2443 | Noca_2631 | Noca_2443 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PFAM: Fmu (Sun) domain protein; NusB/RsmB/TIM44; KEGG: sco:SCO1472 conserved hypothetical Sun-family protein SCL6.29c; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | 0.751 |
Noca_2631 | fmt | Noca_2631 | Noca_2442 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.926 |
Noca_2631 | folD1 | Noca_2631 | Noca_0641 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.561 |
Noca_2631 | folD2 | Noca_2631 | Noca_3582 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.561 |
Noca_2631 | glyA | Noca_2631 | Noca_2352 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.958 |