STRINGSTRING
Noca_2631 protein (Nocardioides sp. JS614) - STRING interaction network
"Noca_2631" - B12-dependent methionine synthase in Nocardioides sp. JS614
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Noca_2631B12-dependent methionine synthase (1244 aa)    
Predicted Functional Partners:
Noca_3083
5,10-methylenetetrahydrofolate reductase (296 aa)
 
 
  0.998
metK
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme (396 aa)
   
 
  0.992
Noca_3943
Cystathionine gamma-synthase (382 aa)
   
 
  0.991
Noca_3292
Cys/Met metabolism pyridoxal-phosphate-dependent protein (359 aa)
   
 
  0.991
Noca_0976
Cystathionine gamma-lyase (387 aa)
   
 
  0.991
Noca_3629
O-acetylhomoserine/O-acetylserine sulfhydrylase (428 aa)
       
  0.990
ahcY
S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (476 aa)
   
 
  0.990
Noca_0939
Cystathionine beta-synthase (462 aa)
   
 
  0.988
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (482 aa)
   
 
  0.984
gcvP
Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (971 aa)
   
 
  0.983
Your Current Organism:
Nocardioides sp. JS614
NCBI taxonomy Id: 196162
Other names: N. sp. JS614, Nocardioides, Nocardioides JS614, Nocardioides sp. JS614
Server load: low (9%) [HD]